Showing 1–25 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Xiaoyu Lu, Yuan Jiang, Rui Zhang, Yangyi Zhang, Jing Li, et al.
**BACKGROUND:** Long-term transmission of multidrug-resistant tuberculosis (MDR-TB) challenges TB control by generating new cases and enabling the emergence of extensively resistant strains. We investigated its epidemiologic and bacterial drivers in Shanghai, China. **METHODS:**…
Asare P, Asante-Poku A, Osei-Wusu S, Otchere ID, Yeboah-Manu D
…, remains a global health problem. West Africa has a unique epidemiology of TB that is characterized by medium- to high-prevalence. Moreover, the geographical restriction of M. africanum to the sub-region makes West Africa have an extra burden to deal with a two-in-one pathogen. …
Azger Dusthackeer, Mahizhaveni Balasubramanian, Sam Ebenezer Rajadas, Christy Rosaline Nirmal, Padmasini Elango, et al.
**INTRODUCTION:** The rise of drug-resistant tuberculosis poses a significant challenge in patient management. Epidemiological cut-off values define drug resistance in. In our previous study, we reported deviations from the WHO-recommended epidemiological cut-off values and ident…
Dixit A, Ektefaie Y, Kagal A, Freschi L, Karyakarte R, et al.
…orld's burden, are not well studied. We conducted a genomic epidemiology study to compare epidemiological success, host factors, and drug resistance among the 4 major Mycobacterium tuberculosis (Mtb) lineages (L1-L4) circulating in Pune, India. Methods We performed whole-genome s…
Han Z, Li J, Sun G, Gu K, Zhang Y, et al.
Background Multidrug-resistant tuberculosis (MDR-TB) has become a major public health problem in China, with mounting evidence suggesting that recent transmission accounts for the majority of MDR-TB. Here we aimed to reveal the transmission pattern of an MDR-TB outbreak in the Ji…
Starshinova A, Belyaeva E, Doktorova N, Korotkevich I, Kudlay D
Aim Because of the COVID-19 pandemic, many support programs for tuberculosis (TB) patients have been discontinued and TB mass screening activities decreased worldwide, resulting in a decrease in new case detection and an increase in TB deaths (WHO, WHO global lists of high burden…
Bhembe NL, Green E
…al challenge. Making it imperative to examine the molecular epidemiology of drug resistant tuberculosis. Molecular epidemiology methods can evaluate transmission patterns and risk factors, ascertain transmission cases of multidrug-resistant tuberculosis (MDR-TB) and furthermore d…
Dolynska MG, Dolynskyi GA, Duhlii TV, Petrenko VI
Objective The aim: To analyze molecular epidemiology features of M. tuberculosis in Kyiv oblast; and to identify the safest mode of TB treatment, which will allow clinicians to minimize the risk of drug-resistant strains nosocomial transmission. Patients and methods Materials and…
Bainomugisa A, Meumann EM, Rajahram GS, Ong RT, Coin L, et al.
…alth priority in eastern Malaysia. Knowledge of the genomic epidemiology of tuberculosis can help tailor public health interventions. Our aims were to determine tuberculosis genomic epidemiology and characterize resistance mutations in the ethnically diverse city of Kota Kinabalu…
Oliveira O, Gaio R, Carvalho C, Correia-Neves M, Duarte R, et al.
Background Increasing multidrug-resistant tuberculosis (MDR-TB) incidence is a major threat against TB eradication worldwide. We aim to conduct a detailed MDR-TB study in Portugal, an European country with endemic TB, combining genetic analysis and epidemiological data, in order …
Yu Y, Xiang Y, Liu H, Yang S, Li M, et al.
Objectives This study aimed to investigate the epidemiological and drug resistance (DR) characteristics of extrapulmonary tuberculosis (EPTB) in South-Central China. Methods EPTB inpatients who were culture-positive for Mycobacterium tuberculosis were retrospectively included in …
Almeida SM, Malaspina AC, Leite CQF, Saad MHF
A drug resistance survey involving Mycobacterium tuberculosis isolated from patients of a tertiary Hospital in the Rio de Janeiro city (RJ), Brazil, between the years 1996 and 1998 revealed a high frequency of isoniazid (HR) resistance. These isolates were revisited and genotyped…
Jiang H, Zhang G, Yin J, Zhao D, Liu F, et al.
Background In 2005, China established an internet-based Tuberculosis Information Management System (TBIMS) to monitor changes in tuberculosis (TB). Many scholars have conducted epidemiological research using TBIMS; however, few studies assessing control strategies have been perfo…
Getachew Seid, Andrea Maurizio Cabibbe, Betselot Zerihun, Ayinalem Alemu, Getu Diriba, et al.
**BACKGROUND:** The genotyping of the M. tuberculosis complex has significantly enhanced the comprehension of transmission dynamics and is employed to substantiate transmission dynamics among epidemiologically interconnected cases. This investigation sought to examine genomic div…
Yi Liu, Jue Wang, Xiaojie Wan, Wang Peng, Jingwei Guo, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) remains a major public health challenge in China, yet long-term epidemiological data from key regions such as Hunan Province in South-Central China are still limited. **OBJECTIVE:** This study aimed to characterize the epidemio…
Aandahl RZ, Bhatia S, Vaudagnotto N, Street AG, Francis AR, et al.
Molecular epidemiology uses genetic information from bacterial isolates to shed light on the population structure and dynamics of pathogens. Bacterial pathogens can now be studied by whole genome sequencing, but for some well-studied pathogens such as Mycobacterium tuberculosis a…
Al-Jardani A, Al Yaquobi F, Adikaram C, Al Wahaibi A, Al-Balushi L, et al.
…and exploring the geospatial distribution to understand the epidemiology of TB in Oman. Methods Confirmed cases with spoligotyping clusters were randomly selected. WGS of 70 isolates were selected for final analysis. Correlation of epidemiological and geospatial data was conducte…
Walker TM, Merker M, Knoblauch AM, Helbling P, Schoch OD, et al.
Background The risk of tuberculosis outbreaks among people fleeing hardship for refuge in Europe is heightened. We describe the cross-border European response to an outbreak of multidrug-resistant tuberculosis among patients from the Horn of Africa and Sudan. Methods On April 29 …
Tatara MB, Perdigão J, Viveiros M, Kritski A, Silva KED, et al.
…ltidrug resistant. This is the first study on the molecular epidemiology and drug resistance profile of MTB from Roraima. Herein, we describe high diversity of genetic profiles circulating in this region that may be driven by the introduction of new strain types because of large …
Yang C, Gao Q
…tize the strategies for TB control. Evidence from molecular epidemiology studies has delineated the recent transmission of Mycobacterium tuberculosis (M. tuberculosis) strains in many settings. However, the transmission patterns of TB in most areas of China are still not clear. S…
Wasakul V, Disratthakit A, Mayxay M, Chindavongsa K, Sengsavath V, et al.
…nce, Laos, during the 2020-21 malaria season, using genomic epidemiology methods to elucidate parasite population dynamics and identify its causes. Methods In this genetic analysis, 2164 P falciparum dried blood spot samples were collected from southern Laos between Jan 1, 2017, …
Christopher PM, Widysanto A
…e use of GeneXpert MTB/RIF assay to determine the molecular epidemiology of RR-TB in an urban setting of Indonesia. Methods All molecular epidemiological and microbiological databases were retrospectively examined from GeneXpert MTB/RIF assay results in Siloam Hospital Lippo Vill…
Wilczek NA, Brzyska A, Bogucka J, Sielwanowska WE, Żybowska M, et al.
Ukraine is at the forefront of one of the largest outbreaks of tuberculosis (TB) in Europe, including multidrug-resistant tuberculosis. Due to the ongoing armed conflict in this area, there is a significant number of refugees from Ukraine to other European countries. The aim of t…
Edwards BD, Edwards J, Cooper R, Kunimoto D, Somayaji R, et al.
…R-TB cases in Alberta, Canada from 2007-2017 to explore the epidemiology and outcomes in our low incidence setting. We performed a descriptive analysis of the epidemiology, treatment regimens and associated outcomes, calculating differences in continuous and discrete variables us…
Goroh MMD, Rajahram GS, Avoi R, Van Den Boogaard CHA, William T, et al.
…ninsular Malaysia. The aim of this study is to describe the epidemiology of TB in Sabah to identify risk groups and hotspots of TB transmission. Methods We conducted a retrospective review of TB cases notified in Sabah, Malaysia, between 2012 and 2018. Using data from the state's…