Showing 1–25 of 200 documents
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Ketema DB, Alene M, Assemie MA, Yismaw L, Merid MW
Background The emergency of drug resistant tuberculosis is a major public health concern worldwide including Ethiopia. However, little is known about risk factors of mortality among drug resistant tuberculosis patients in the study site. Thus, this study was aimed to estimate the…
Yang J, Lu Y, Chen Y, Wang Y, Wang K
Objective This study aims to analyze the drug resistance spectrum, genetic diversity, and transmission dynamics to provide a basis for the prevention and control of drug-resistant (DR) tuberculosis (TB) epidemics. Methods This retrospective study is based on routine national drug…
Shah V, Yogesh M, Kothari DR, Gandhi RB, Nagda JJ
Background Characterizing risk factors for drug-resistant tuberculosis (TB) is critical to guide targeted interventions in high-burden settings like India. We aimed to identify socioeconomic, lifestyle, and clinical factors associated with drug-sensitive and drug-resistant TB acq…
Zeng X, Kwok JS, Yang KY, Leung KS, Shi M, et al.
Background Drug resistance in Mycobacterium tuberculosis (MTB) is one of the major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain all of the cases of resistance and little research has focused on the relationship between insertions / deletions …
Nimmo C, Millard J, Faulkner V, Monteserin J, Pugh H, et al.
Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice. Compared to other bacteria, it has a well conserved genome due to its role as an obligate human pathogen that has …
Maeda T, Kawada M, Sakata N, Kotani H, Furusawa C
Drug-resistant tuberculosis (TB) is a growing public health problem. There is an urgent need for information regarding cross-resistance and collateral sensitivity relationships among drugs and the genetic determinants of anti-TB drug resistance for developing strategies to suppre…
Anderson K, Pietersen E, Dheda K, van der Heijden YF
Background Simplified drug-resistant tuberculosis (DR-TB) treatment outcome definitions, mostly centred around receipt of treatment and sputum culture status at 6 months after treatment initiation, have been proposed, but have not been widely evaluated in resource-limited setting…
Yadav M, Jain AK, Singhal R, Chadha M, Arora VK, et al.
…ground There is paucity of data on incidence and pattern of drug resistance in spinal TB. This prospective observational study was conducted to document the incidence and drug-resistance pattern among primary and presumptive resistant cases. Methods 59 consecutive cases diagnosed…
Jiang Z, Lu Y, Liu Z, Wu W, Xu X, et al.
Prediction of antimicrobial resistance based on whole-genome sequencing data has attracted greater attention due to its rapidity and convenience. Numerous machine learning-based studies have used genetic variants to predict drug resistance in Mycobacterium tuberculosis (MTB), ass…
Mortimer TD, Weber AM, Pepperell CS
…nd global TB control efforts are increasingly threatened by drug resistance in Mycobacterium tuberculosis . Unlike most bacteria, where lateral gene transfer is an important mechanism of resistance acquisition, resistant M. tuberculosis arises solely by de novo chromosomal mutati…
Cheng N, Wu S, Luo X, Xu C, Lou Q, et al.
Purpose To investigate the CT features of drug-resistant pulmonary tuberculosis (DR-PTB) and the diagnostic value of CT in DR-PTB diagnosis to provide imaging evidence for the timely detection of drug-resistant Mycobacterium tuberculosis . Materials and methods A total of 1546 ca…
Chen X, He G, Wang S, Lin S, Chen J, et al.
[This corrects the article DOI: 10.3389/fmicb.2019.01741.].
Juexin Wang, Chan Chen, Huan Fang, Yong Liao, Qiong Lei, et al.
**OBJECTIVE:** The study aimed to understand the drug resistance profile and transmission characteristics of drug-resistant(MTB) in Ganzhou, China, to provide a scientific basis for developing prevention and control strategies. **METHODS:** DNA extracted from re-cultured positiv…
Bhagwat A, Deshpande A, Parish T
Drug resistance is an increasing problem for the treatment of tuberculosis. The prevalence of clinical isolates with pre-existing resistance needs to be considered in any drug discovery program. Non-specific mechanisms of resistance such as increased efflux or decreased permeabil…
Yao L, Wang B, Chen X, Liu Q, Sheng J, et al.
…uate the safety and efficacy of decortication for stage III drug-resistant tuberculous empyema (TE). Methods We analysed all patients with stage III TE who underwent decortication between March 2015 and October 2019 at Wuhan Pulmonary Hospital. The patients were divided into 2 gr…
Bao X, Liang S, Li J, Ye Q, Wu D, et al.
…ssess the prevalence and control effect of tuberculosis and drug-resistant tuberculosis (TB) in Anhui province, and analyze the trends in the changing drug resistance spectrum of Mycobacterium tuberculosis (Mtb) isolated in Anhui province from 2016 to 2022. Methods From 2016 to 2…
Giri VP, Giri OP, Pandey PT, Mishra KN, Prasad RS, et al.
Background Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug re…
Hui Cen, Peng Zhang, Yunchao Ling, Guoping Zhao, Guoqing Zhang
Understanding the mechanisms of drug resistance in(MTB) is essential for the rapid detection of resistance and for guiding effective treatment, ultimately contributing to reducing the global burden of tuberculosis (TB). Under anti-TB drugs pressure, MTB continues to accumulate re…
Gupta-Wright A, Fielding K, van Oosterhout JJ, Alufandika M, Grint DJ, et al.
…ak routine virological monitoring has driven increasing HIV drug resistance. We investigated ART failure, drug resistance, and early mortality among patients with HIV admitted to hospital in Malawi. Methods This observational cohort study was nested within the rapid urine-based s…
Xu G, Liu H, Jia X, Wang X, Xu P
…n health. Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key factor in formulating treatment regimen and evaluating the prognosis of TB. Compared with other drugs resistance, the RIF-R mechanism of Mycobacterium tuberculosis (M. tuber…
Machado D, Lecorche E, Mougari F, Cambau E, Viveiros M
Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis , drug resistance may also result from the overactivity of efflux systems, which is mostl…
Sharma M, Roy N, Banerjee R, Kishore J, Jakhar A
Introduction Drug-resistant tuberculosis (DR-TB) is a major concern to effective control of tuberculosis (TB) in India and the likelihood of drug resistance increases with repeated exposure to anti-TB drugs. India has emerged as one of the leading contributors of DR-TB in the wor…
Guiqing He, Qingyong Zheng, Jing Wu, Jingjie Luan, Yuanfei Ji, et al.
…editions ofcomplex (MTBC) mutations catalog associated with drug resistance in 2021 and 2023, respectively. The aim of this study was to evaluate the resistance prediction by mutation catalog for nine anti-tuberculosis drugs in rifampicin (RIF)-resistant tuberculosis (RR-TB) in W…
Dai E, Zhang H, Zhou X, Song Q, Li D, et al.
The emergence and spread of drug-resistant Mycobacterium tuberculosis is of global concern. To improve the understanding of drug resistance in Mycobacteria, numerous studies have been performed to discover diagnostic markers and genetic determinants associated with resistance to …
Kara Lukas, Madeleine T Dang, Clare Necas, Vishwanath Venketaraman
…uberculosis (TB) is a global health challenge caused bywith drug resistance, treatment toxicity, and treatment adherence challenges continuing to impede control efforts. The objective of this review is to explore current advancements in TB treatment, for both drug-sensitive and d…