Showing 1–25 of 47 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Bhosale S, Prabhakar A, Srivastava S, Raj A, Purohit S, et al.
…of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a rise and there is inadequate literature concentrating on the precise pattern of resistance in Indian subcontinent which harbors 24% of global prevalence. The ai…
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
Diriba G, Kebede A, Tola HH, Alemu A, Yenew B, et al.
…s limited information available on lineages associated with drug resistance among extrapulmonary tuberculosis patients in Ethiopia. In this study, researchers looked into Mycobacterium tuberculosis lineages linked to drug resistance in patients with extrapulmonary tuberculosis in…
Schami A, Islam MN, Wall M, Hicks A, Meredith R, et al.
In recent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health. Although M.tb's complex and protective cell envelope has been widely studied, little is known about how levels of periphe…
Dagne B, Desta K, Fekade R, Amare M, Tadesse M, et al.
Background Drug-resistance in Mycobacterium tuberculosis complex remains a major health burden in human history and still is a major leading cause of death in developing countries including Ethiopia. Early detection of all forms of drug-resistant Tuberculosis(TB) is a key factor …
Liang D, Song Z, Liang X, Qin H, Huang L, et al.
…lic health issue in China. Nevertheless, the prevalence and drug resistance characteristics of isolates vary in different regions and provinces. In this study, we investigated the population structure, transmission dynamics and drug-resistant profiles of Mtb in Guangxi, located o…
Kostyukova I, Pasechnik O, Mokrousov I
Russia is a high-burden area for multidrug-resistant tuberculosis (MDR-TB). Here, we studied the epidemiological situation and drug resistance patterns of Mycobacterium tuberculosis in the Omsk region in Western Siberia. M. tuberculosis isolates ( n = 851) were recovered from new…
Liang Z, Liao W, Chen Q, Li H, Ye M, et al.
Drug-resistant tuberculous meningitis (TBM) is the most devastating and critical form of extrapulmonary tuberculosis. Here, we present a case of a 45-year-old male with pre-extensive drug-resistant tuberculosis meningitis (pre-XDR-TBM). He underwent emergency surgery for the long…
Kardan-Yamchi J, Amini S, Hamzelou G, Rahimi Foroushani A, Ghodousi A, et al.
…ction, a reduction of infectiousness, prevention of further resistance development and surveillance of drug-resistant TB. MTBDRsl VER 2.0 was used to detect resistance to second-line anti-tuberculosis drugs on 35 rifampicin-resistant M. tuberculosis (RR-MTB) isolates compared to …
Zhang X, Chen X, Wang B, Fu L, Huo F, et al.
Aim: Fluoroquinolones (FQs) are the cornerstone in treating drug-resistant tuberculosis (TB); the prevalence of TB among the population is diverse in different regions, understanding the relationship between resistance pattern and molecular characteristic of FQs in preextensive d…
Zhdanova S, Jiao WW, Sinkov V, Khromova P, Solovieva N, et al.
This study aimed to determine phenotypic and genotypic drug resistance patterns of Mycobacterium tuberculosis strains from children with tuberculosis (TB) in China and Russia, two high-burden countries for multi/extensively-drug resistant (MDR/XDR) TB. Whole-genome sequencing dat…
Nurlan Takenov, Alibi Kaziyev, Asfendiyar Mukhamadi, Lyailya Chingissova, Bekzat Toxanbayeva, et al.
Tuberculosis, particularly multidrug-resistant TB (MDR-TB), remains a major public health concern in Kazakhstan, where 26% of new TB cases are MDR, far exceeding the global average. To better understand the genetic diversity, drug resistance, and transmission dynamics ofin Kazakh…
Breli Bonheur Ngouama, Jean Claude Djontu, Darrel Ornelle Elion Assiana, Freisnel Hermeland Mouzinga, Mita Naomie Merveille Dello, et al.
…CKGROUND:** WHO strategy to end Tuberculosis (TB) calls for drug susceptibility testing of Mycobacterium tuberculosis (MTB) for all patients, in high TB burden settings. Thus, this study aimed to investigate the MTB drug resistance profiles and related risk factors among patients…
Pinhata JMW, Brandao AP, Mendes FF, Rabello MCDS, Ferrazoli L, et al.
…ions in katG, inhA and rpoB genes, and isoniazid phenotypic resistance levels in Mycobacterium tuberculosis isolates from drug-resistant TB patients from São Paulo state, Brazil. Isolates resistant to the critical concentration of isoniazid in MGIT (0.1 µg/mL) were screened for m…
Morey-León G, Andrade-Molina D, Fernández-Cadena JC, Berná L
…ite of efforts to reduce the disease, increasing antibiotic resistance has contributed to persist in the top 10 causes of death worldwide. In fact, the increased cases of multi (MDR) and extreme drug resistance (XDR) worldwide remains the main challenge for tuberculosis control. …
Jain P, Singh U, Kumar V, Ratnam R, Jain A
…or diagnosis of Mycobacterium tuberculosis and detection of drug resistance among EPTB cases. Methods The EP samples were subjected to CBNAAT (Xpert MTB/RIF, Cepheid, USA) and wherever possible, to LC (MGIT 960, Becton Dickinson, USA) followed sequentially by first line and secon…
Pinhata JMW, Brandao AP, Gallo JF, Oliveira RS, Ferrazoli L
We assessed the performance of MTBDRsl for detection of resistance to fluoroquinolones, aminoglycosides/cyclic peptides, and ethambutol compared to BACTEC MGIT 960 by subjecting simultaneously to both tests 385 phenotypically multidrug-resistant-Mycobacterium tuberculosis isolate…
Namburete E
…ng the genetic diversity of M. tuberculosis strains causing drug-resistant tuberculosis (DR-TB) in high burden TB and low resources countries such as Mozambique is a key factor to TB disease spread control and world TB epidemic control. Whole-genome sequencing (WGS) better descri…
Gupta M, Ish P, Malhotra N
The recent guidelines on the Programmatic Management of Drug-Resistant Tuberculosis (DR-TB) in India (PMDT) have been released in March 2021 on World TB Day. The new guidelines have considered emerging diagnostic trends including TrueNat, Xpert Mtb/XDR, Next generation sequencing…
Jantarabenjakul W, Supradish Na Ayudhya P, Suntarattiwong P, Thepnarong N, Rotcheewaphan S, et al.
Background The prevalence of drug-resistant tuberculosis (DR-TB) in adults has stabilized in the past decade. Our study aimed to describe the prevalence of DR-TB in Thai children between 2006 and 2021. Materials and methods Children younger than 15 years old who had culture-confi…
Lindiwe Modest Faye, Mojisola Clara Hosu, Ntandazo Dlatu, Vatiswa Henge-Daweti, Teke Apalata
Hearing loss (HL) is a major global health concern, with drug-induced ototoxicity contributing significantly, particularly in patients undergoing treatment for drug-resistant tuberculosis (DR-TB). In South Africa, where both TB and HIV are prevalent, the risk of treatment-related…
Greif G, Coithino C, Bentancor MN, Robello C
…tive tool for the analysis of tuberculosis transmission and drug-resistance. We used WGS to analyze the Mycobacterium tuberculosis evolution from isoniazid monoresistance to MDR/preXDR during a prolonged household outbreak. The outbreak started with a isoniazid resistant strain (…
Faye LM, Hosu MC, Apalata T
This study investigated the characteristics and outcomes of drug-resistant tuberculosis patients in selected rural healthcare facilities in the Eastern Cape, South Africa. A retrospective review of clinical records from 456 patients, covering the period from January 2018 to Decem…
Linhares LA, Dos Santos Peixoto A, Correia de Sousa LA, Lucena Laet JP, da Silva Santos AC, et al.
…en causes of death worldwide. The alarming increase in multidrug-resistant and extensively resistant variants (MDR, pre-XDR, and XDR) makes the disease more difficult to treat and control. New drugs that act against MDR/XDR strains are needed for programs to contain this major ep…
Podlekareva DN, Folkvardsen DB, Skrahina A, Vassilenko A, Skrahin A, et al.
Background To cure drug-resistant (DR) tuberculosis (TB), the antituberculous treatment should be guided by Mycobacterium tuberculosis drug-susceptibility testing (DST). In this study, we compared conventional DST performed in Minsk, Belarus, a TB DR high-burden country, with ext…