Showing 1–25 of 186 documents
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Bui VCB, Yaniv Z, Harris M, Yang F, Kantipudi K, et al.
Tuberculosis (TB) drug resistance is a worldwide public health problem. It decreases the likelihood of a positive outcome for the individual patient and increases the likelihood of disease spread. Therefore, early detection of TB drug resistance is crucial for improving outcomes …
Ankita Pal, Sapna Pal, Shweta Mahapatra, Apratim Pandey, Debasisa Mohanty
…d on the statistical significance of their association with resistance or susceptibility to various drugs. However, the mechanism by which they confer resistance to drugs is often not understood. To address these gaps, we combined known resistance associated mutations from the WH…
Sebastian J, Thomas A, Levine C, Shrestha R, Levy S, et al.
…atment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis population. We developed a multitranswell roboti…
Qian Zhai, Xianglong Kong, Qian Li, Na Yang
…tinase-3-like protein 1 (YKL-40) levels are associated with drug-resistant Mycobacterium tuberculosis in children with pulmonary tuberculosis. **METHODS:** In this prospective observational study, 235 pediatric pulmonary tuberculosis patients treated at Hebei Provincial Chest Ho…
Welekidan LN, Yimer SA, Skjerve E, Dejene TA, Homberset H, et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients. Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between July 2018 and Augus…
Yang F, Yu H, Kantipudi K, Karki M, Kassim YM, et al.
Background Tuberculosis (TB) drug resistance is a worldwide public health problem that threatens progress made in TB care and control. Early detection of drug resistance is important for disease control, with discrimination between drug-resistant TB (DR-TB) and drug-sensitive TB …
Allué-Guardia A, García JI, Torrelles JB
… (MDR), extensively (XDR), extremely (XXDR) and total (TDR) drug-resistant Mycobacterium tuberculosis ( M.tb ) strains have emerged as a threat to public health worldwide, stressing the need to develop new tuberculosis (TB) prevention and treatment strategies. It is estimated tha…
Shurygina AS, Zabolotnykh NV, Vinogradova TI, Vitovskaya ML, Dogonadze MZ, et al.
The steady rise of drug-resistant tuberculosis (TB), which renders standard therapy regimens ineffective, necessitates the development of innovative treatment approaches. Immunotherapeutic vaccines have the potential to effectively regulate the anti-TB immune response and enhance…
John W Wilson, Zelalem Temesgen, James T Gaensbauer
…of management updates recently have been published for both drug-susceptible and drug-resistant tuberculosis (TB), TB in children, and contacts of patients with drug-resistant TB. The operationalization and application of these recommendations, which reflect favorable clinical tr…
Swargam S, Kumari I, Kumar A, Pradhan D, Alam A, et al.
… gene variations, INDEL/synonymous/PE-PPE (IDP family), and drug resistance from sample data, or are limited to specific objectives, such as drug resistance. It is understood that drug resistance and lineage-specific issues require an elaborate prioritization of identified varian…
Oriekot A, Sereke SG, Bongomin F, Bugeza S, Muyinda Z
…e. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and rifampicin-resistant (RR) pulmonary TB (PTB). This study aimed to compare the chest x-ray (CXR) patterns of microbiologically confirmed DS and RR PTB cases stratified by HIV serostatus in Uganda. …
Yun YJ, Lee JS, Yoo JC, Cho E, Park D, et al.
…kground Rifampicin (RFP) is one of the principal first-line drugs used in combination chemotherapies against Mycobacterium tuberculosis, and its use has greatly shortened the duration of chemotherapy for the successful treatment of drug-susceptible tuberculosis. Compensatory muta…
Karki M, Kantipudi K, Yang F, Yu H, Wang YXJ, et al.
Classification of drug-resistant tuberculosis (DR-TB) and drug-sensitive tuberculosis (DS-TB) from chest radiographs remains an open problem. Our previous cross validation performance on publicly available chest X-ray (CXR) data combined with image augmentation, the addition of s…
Omollo C, Singh V, Kigondu E, Wasuna A, Agarwal P, et al.
…ous agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tubercul…
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong
…B) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control. An increasingly recognized and complex challenge is heteroresistance, the coexistence of drug-susceptible and drug-resistantsubpopulation…
Hauptmann M, Kalsdorf B, Akoh-Arrey JE, Lange C, Schaible UE
… in relationship to the level of Mycobacterium tuberculosis drug response. Methods Stool, sputum, and oral swab samples were analysed from participants with treatment-naïve TB and participants treated for drug-susceptible TB (DS-TB), drug-resistant TB without injectable drugs (DR…
John Kauffman, Jake Cuevas, Janaya Feiner, Margaret Metzger, Gauri Shetye, et al.
…s an urgent need to develop new anti-tuberculosis (anti-TB) drugs to tackle drug-resistant strains of Mycobacterium tuberculosis (M.tb). Whereas antimicrobial peptides (AMPs) have received attention because of their antibacterial properties, oligo-N-substituted glycines (peptoids…
Wang T, Yang Q, Gao Y, Zhang R, Zhou C, et al.
…mputed tomography (CT) manifestations of rifampicin primary drug-resistant pulmonary tuberculosis in Liangshan Yi Autonomous Prefecture. Patients and methods A total of 100 inpatients with confirmed primary rifampicin-resistant pulmonary tuberculosis were recruited from January 2…
Deng L, Wang Q, Liu H, Jiang Y, Xu M, et al.
…, embB , gid , and cut1 ) under positive selection in multi-drug resistance (MDR) strains but not in drug-susceptible (DS) strains, in which 27 mutations were drug-resistant loci, 9 mutations were non-drug-resistant loci but were in drug-resistant genes, 2 mutations were compensa…
Elmadbouly AA, Abdul-Mohymen AM, Eltrawy HH, Elhasan HAA, Althoqapy AA, et al.
Background Drug-resistant Tuberculosis (DR-TB) is a global health burden with high morbidity and mortality in developing countries including Egypt. The susceptibility to infection with DR-TB strains may be genetically determined. Several interleukin gene polymorphisms were invest…
Muhammad Dayyab F, Iliyasu G, Garba Ahmad B, Aliyu Umar I, Musa Shuaib N, et al.
Background Mycobacterium tuberculosis with resistance to first line and second line anti tuberculous drugs is a serious setback in the treatment of tuberculosis (TB). The COVID-19 pandemic constitutes a serious threat that could unwind the recent gains made thus far in the contro…
Beyene N, Sitotaw AL, Telila EG, Gebre HA, Alemu NB, et al.
Although detection of drug-susceptible TB by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling-trained African giant pouched rats has been known for more than a decade, the detection of drug-resistant TB (DR-TB) using rats has never been explored before. We present what we bel…
Van Wyk SS, Nliwasa M, Seddon JA, Hoddinott G, Viljoen L, et al.
Background Transmission of drug-resistant tuberculosis (DR-TB) is ongoing. Finding individuals with DR-TB and initiating treatment as early as possible is important to improve patient clinical outcomes and to break the chain of transmission to control the pandemic. To our knowled…
V Shukatka, L Skoklyuk, M Germanovych, A Bogdanov, T Ivanenko, et al.
…CKGROUND:** Ukraine faces intersecting epidemics of HIV and drug-resistant TB (DR-TB), with high risk of progression from TB infection to active disease. The Support TB Control Efforts in Ukraine project supported the National TB Program's efforts to operationalise World Health O…
Y L Lew, M M D Goroh, S T Yerkovich, A M H Seow, G S Rajahram, et al.
**OBJECTIVES:** Addressing drug-resistant tuberculosis (DR-TB) is a priority of the tuberculosis (TB) programme. People with DR-TB frequently have worse outcomes and require more costly and complex management, compared with those with drug-sensitive TB (DS-TB). Our study examined…