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Lee JH, Garg T, Lee J, McGrath S, Rosman L, et al.
…icate that the use of World Health Organization recommended diagnostics for TB reduced delays in diagnosing and initiating TB treatment. Future studies evaluating performance and impact of diagnostics should consider reporting time delay estimates based on the standardized report…
Yilin Wang, Zichun Ma, Zubi Liu, Xiaowei Dong, Wei Shu, et al.
…and support broader implementation. Integrating tongue swab diagnostics with existing TB control programs could enhance the detection accuracy, improve drug resistance monitoring and reduce transmissions.
Juliana G E Bartels, Nurlan Takenov, Lyailya Chingissova, Anar Rakisheva, Ainur Eleusizova, et al.
**BACKGROUND:** Rapid, accurate detection ofand drug resistance is crucial to reduce tuberculosis (TB) burden and prevent development of drug resistance in high-burden drug-resistant TB regions. **METHODS:** From December 2021 to July 2022, sputum samples from 1214 adult patient…
Assebe LF, Erena AK, Fikadu L, Alemu B, Baruda YS, et al.
…ational TB guideline recommends the primary use of rapid TB diagnostics whenever feasible, there is limited evidence available that assess the efficiency of deploying various diagnostic tools in the country. Hence, this study aims to evaluate the cost-effectiveness of rapid TB/MD…
Ng KC, Meehan CJ, Torrea G, Goeminne L, Diels M, et al.
…s have adopted connectivity solutions that allow linking of diagnostics, real-time capture, and shared repository of these test results. However, these connected diagnostics and readily available test results are not used to their full capacity, as we have yet to capitalize on fu…
Andama A, Somoskovi A, Mandel B, Bell D, Gutierrez C
…ug resistant TB. The ultimate goal is to improve laboratory diagnostics and better individualized managementof detected TB, and make an important contribution toward eliminating this global epidemic. RATIONALE: Tuberculosis persists as one of the world's most deadly infectious di…
Lin D, Wang X, Li Y, Wang W, Li Y, et al.
The prevalence of drug-resistant Mycobacterium tuberculosis (Mtb) strains makes disease control more complicated, which is the main cause of death in tuberculosis (TB) patients. Early detection and timely standard treatment are the key to current prevention and control of drug-re…
Modlin SJ, Mansjö M, Werngren J, Ejike CM, Hoffner SE, et al.
…TB) reported as PZA-susceptible (PZA-S) by common molecular diagnostics. Phenotypic susceptibility testing (pDST) indicated PZA-R TB. Targeted Sanger sequencing reported wild-type PncA, indicating PZA-S TB. Whole Genome Sequencing (WGS) by PacBio and IonTorrent both detected dele…
Muniyandi M, Lavanya J, Karikalan N, Saravanan B, Senthil S, et al.
Background The National Tuberculosis Elimination Programme (NTEP) of India is aiming to eliminate TB by 2025. The programme has increased its services and resources to strengthen the accurate and early detection of TB. It is important to estimate the cost of TB diagnosis in India…
Kassa GM, Merid MW, Muluneh AG, Wolde HF
Background To end Tuberculosis (TB) by 2030, early detection and timely treatment of Drug-Resistant Tuberculosis (DR-TB) is vital. The role of rapid, accurate, and sensitive DR-TB diagnostic tool is indispensable to accelerate the TB control program. There are evidence breaks in …
Anuj Pathak, Reena Raveendran, Jaswinder Kaur Oberoi, Chand Wattal, Anil Arora, et al.
**BACKGROUND:** Abdominal tuberculosis (TB) poses diagnostic difficulties due to its vague symptoms and low bacterial load. Culture, the gold standard, is limited by a prolonged turnaround time of up to eight weeks. Xpert MTB/RIF Ultra (Xpert Ultra), a rapid, automated molecular …
Anura David, Lyndel Singh, Manuel Pedro da Silva, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane, et al.
**UNLABELLED:** Despite the availability of molecular diagnostics, only 48% of newly diagnosed tuberculosis (TB) cases were confirmed using nucleic acid amplification tests in 2023. The MAX Multi Drug Resistant Tuberculosis (MAX MDR-TB) assay detectscomplex (MTBC) and resistance …
Zhen Feng, Shijia Ge, Peiwen Miao, Mei Liu, Qing Li, et al.
**UNLABELLED:** Effective tuberculosis (TB) management relies on prompt diagnosis ofcomplex (MTBC) and associated drug resistance. The Sanity 2.0 assay is a high-resolution melting assay designed for direct respiratory sample testing, enabling simultaneous detection of MTBC and r…
Ankur Kumar, Amresh Kumar Singh, Vivek Gaur, Ashwini Kumar Mishra, Anita Mehta, et al.
…prevalence (4.13%) underscores the need for rapid molecular diagnostics to guide treatment. However, global EPTB burden estimates remain inconsistent, necessitating standardized surveillance and diagnostic protocols to improve detection accuracy and inform public health strategie…
Getchell M, Ansah JP, Lim D, Basilio R, Tablizo F, et al.
Background Limited diagnostic testing for drug-resistant TB (DR-TB) may lead to high rates of misdiagnosis and undertreatment. Current diagnostic tests focus only on detection of rifampicin-resistant TB (RR-TB). This study aims to determine the impact of improved diagnostic testi…
Ngabonziza JS, Habimana YM, Decroo T, Migambi P, Dushime A, et al.
SETTING: In 2005, in response to the increasing prevalence of rifampicin-resistant tuberculosis (RR-TB) and poor treatment outcomes, Rwanda initiated the programmatic management of RR-TB, including expanded access to systematic rifampicin drug susceptibility testing (DST) and sta…
Sophia B Georghiou, Nestani Tukvadze, Camilla Rodrigues, Shaheed Vally Omar, Andrea Maurizio Cabibbe, et al.
**INTRODUCTION:** Early and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is essential for improving treatment outcomes. Phenotypic drug susceptibility testing (pDST) is comprehensive but slow, while rapid molecular assays provide resistance information for a limited …
Risha Hazarika, Sanjukta Patra
Rifampicin resistance continues to pose a challenge to successful tuberculosis (TB) control, mainly driven by mutations in the rpoB gene of Mycobacterium tuberculosis. Although most diagnostic tools, such as Xpert MTB/RIF, Xpert Ultra, and line probe assays, focus on the standard…
Schlanderer J, Hoffmann H, Lüddecke J, Golubov A, Grasse W, et al.
…allenge for combatting the disease. Rapid and comprehensive diagnostics including drug susceptibility testing (DST) would assure early treatment, reduction of morbidity and the interruption of transmission chains. To date, rapid genetic resistance testing addresses only one to fo…
Oliwa JN, Maina J, Ayieko P, Gathara D, Kathure IA, et al.
…r research is needed to develop strategies enhancing use of diagnostics, including innovations to improve access (e.g. specimen referral) and overcoming local barriers to adoption of guidelines and technologies.
Meaza A, Tesfaye E, Mohamed Z, Zerihun B, Seid G, et al.
Background Rapid and sensitive Tuberculosis (TB) diagnosis closer to patients is a key global TB control priority. Truenat assays (MTB, MTB Plus, and MTB-RIF Dx) are new TB molecular diagnostic tools for the detection of TB and Rifampicin (RIF)-resistance from sputum samples. The…
Stephen S, Kadye A, Majuru XN, Madamombe T, Sokwe J, et al.
Background Although Zimbabwe has transitioned out of the 30 high-burden countries, it still remained in the 30 high multidrug-resistant (MDR)/rifampicin-resistant tuberculosis (TB) burden. Rapid detection of rifampicin (RIF) and isoniazid (INH) is essential for the diagnosis of M…
Ramachandran R, Muniyandi M
Introduction Rapid molecular diagnostic methods help in the detection of TB and Rifampicin resistance. These methods detect TB early, are accurate and play a crucial role in reducing the burden of drug resistant tuberculosis. Areas covered: This review analyses rapid molecular di…
Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, et al.
Background The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found u…
Ivy Rukasha, Kabelo G Kaapu, Molebogeng R Lekalakala-Mokaba
**BACKGROUND:**  Drug-resistant tuberculosis (DR-TB) continues to be a major public health threat, especially in high-burden settings like South Africa. Rapid and accurate diagnosis of resistance to rifampicin (RIF) and isoniazid (INH) is essential to ensure that patients re…