Showing 1–25 of 200 documents
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Tjale MA, Ombinda-Lemboumba S, Maphanga C, Mthunzi-Kufa P
… diagnosis, and in addition, we explore point of care (POC) diagnostics as an alternative way to develop TB diagnostic tests and further evaluate whether bioinformatics can be used as an additional screening tool for identification of possible TB biomarkers for the development of…
Qi Y, Li K, Li Y, Guo D, Xu J, et al.
…ularly interspaced short palindromic repeats (CRISPR)-based diagnostics in TB detection. Currently, the clinical diagnosis of M. tuberculosis infection mainly depends on pathogenic and molecular biological methods, including sputum smear, sputum culture, and Xpert. Although CRISP…
Shyamkumar Sriram, Tareq Abualfaraj, Manal Ali Alsharif, Marwa Zalat, Saad Madani Alawfi, et al.
Patients with latent tuberculosis infection are mainly asymptomatic, but they still carry a notable risk of developing active TB, particularly when the host becomes immunosuppressed. Hence, appropriate diagnosis and management for LTBI are essential. Tuberculin skin test (TST) an…
Mamishi S, Pourakbari B, Sadeghi RH, Marjani M, Mahmoudi S
Introduction Several studies have been conducted to find new biomarkers for the discrimination of Latent Tuberculosis Infection (LTBI) from active TB (ATB); however, their findings are inconsistent. The aim of the current study was to evaluate the potential of in vitro antigenspe…
Halliday A, Jain P, Hoang L, Parker R, Tolosa-Wright M, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Eduarda Rabello, Fernanda de-Paris
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, a burden further exacerbated by HIV co-infection and the increasing prevalence of drug-resistant strains. Although a wide range of laboratory diagnostic methods are currently av…
Brinkmann F, Hofgrefe J, Ahrens F, Weidemann J, Berthold LD, et al.
Background The differentiation between latent tuberculosis infection (LTBI) and tuberculosis (TB) relies on radiological changes. Confirming the diagnosis remains a challenge because typical findings are often missing in children. This study evaluates diagnostic sensitivity, spec…
Xie L, Zhu G, Long S, Wang M, Cheng X, et al.
Background Current diagnostic methods cannot effectively distinguish between latent tuberculosis infection (LTBI) and active tuberculosis (ATB). This study aims to explore novel non-invasive diagnostic biomarkers for LTBI and to elucidate possible molecular mechanisms of LTBI pat…
Linsheng Li, Peilong Wang, Zhiming Li, Guangliang Bai, Zhaoyang Ye, et al.
…s a persistent challenge in global TB control, with current diagnostics failing to reliably distinguish these states or predict progression. This study introduces the HeptaTB Dx Model, the first diagnostic signature derived from the crosstalk between cuproptosis and ferroptosis-t…
Shleider Carnero Canales C, Marquez Cazorla J, Furtado Torres AH, Monteiro Filardi ET, Di Filippo LD, et al.
…propelled research into diagnostic tests based on molecular diagnostics, pulmonary immunity, epigenetics, metabolomics, and a current focus on next-generation MTB antigen-based skin test (TBST). It is within these emerging methods that the potential for accurate distinction betwe…
Yi En Ding, Matthew Tze Jian Wong, Mohd Nor Norazmi, Venugopal Balakrishnan, Gee Jun Tye
…o enhance distinction within the infection timeline in LTBI diagnostics. Advancement in immune profiling, dormancy antigen, along with molecular and transcriptomic approaches holds great promise to develop a diagnostic tools with better accuracy to differentiate recent from remot…
Shi H, Yang L, Zhang F, Zhou Y, Zhou Y
Rapid and accurate methods for the diagnosis of tuberculous pleurisy (TP) are urgently needed. Activation markers of tuberculosis (TB)-reactive T cells are considered promising for the diagnosis of active TB (ATB). Different activation indexes may play different roles in the prog…
R A, D M, Kv L, Suriya VR, R K
Testing for latent tuberculosis infection is essential for diagnosing Mycobacterium tuberculosis infections in asymptomatic individuals. Preventing the transition of latent to active tuberculosis is imperative, especially in high-risk populations such as healthcare workers. Inter…
Yoshikazu Mutoh, Yusuke Minato, Yuya Kawamoto, Shogo Hanai, Takumi Umemura, et al.
Evidence regarding the diagnostic value of quantitative interferon-gamma release assay (IGRA) results in elderly populations is limited, and large-scale data for QuantiFERON-TB Gold Plus (QFT-Plus) are scarce. We evaluated QFT-Plus and T-SPOT.TB (T-SPOT) for distinguishing active…
Garlant HN, Ellappan K, Hewitt M, Perumal P, Pekeleke S, et al.
Tuberculosis (TB) remains a significant global health crisis and the number one cause of death for an infectious disease. The health consequences in high-burden countries are significant. Barriers to TB control and eradication are in part caused by difficulties in diagnosis. Impr…
Krutikov M, Faust L, Nikolayevskyy V, Hamada Y, Gupta RK, et al.
…form implementation in key populations. Funding StopTB (New Diagnostics Working Group) and FIND. Translations For the Chinese and Russian translations of the abstract see Supplementary Materials section.
Mahmoudi S, Hosseini Sharif SMS
Introduction Tuberculosis (TB) remains a global health challenge, underscoring the need for accurate diagnosis, particularly for Latent TB Infection. This meta-analysis assesses the diagnostic performance of QuantiFERON-TB Gold Plus (QFT) using Enzyme-Linked Immunosorbent Assay (…
Fu Y, Yang X, Chen H, Lu Y
Tuberculosis (TB) induced by Mycobacterium tuberculosis (Mtb) is a serious global health burden. This study sought to investigate the expression and diagnostic value of serum miR-145 in TB patients and explore the biological function of miR-145 using macrophages. Serum expression…
Ji X, Yao S, Jia H, Sun Q, Wang Y, et al.
Background The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, using long non-coding RNAs (lncRNA…
Burel JG, Babor M, Pomaznoy M, Lindestam Arlehamn CS, Khan N, et al.
Tuberculosis (TB) is a major infectious disease worldwide, and is associated with several challenges for control and eradication. First, more accurate diagnostic tools that better represent the spectrum of infection states are required; in particular, identify the latent TB infec…
Krista Meserve, Cole A Chapman, Mingrui Xu, Haowen Zhou, Heather M Robison, et al.
…entially lead to further Mtb transmission. However, current diagnostics often lack specificity for LTBI and do not inform on TB reactivation risk. We hypothesized that immune profiling readily available QuantiFERON-TB Gold Plus (QFT) plasma supernatant samples could improve LTBI …
Xiuxiu Ji, Siyu Yao, Hongyan Jia, Qi Sun, Yingchao Wang, et al.
**BACKGROUND:** The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, using long non-coding RNAs (l…
Luo D, Yang BY, Qin K, Shi CY, Wei NS, et al.
Purpose Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is important to control the prevalence of tuberculosis; however, there is currently no effective method. The aim of this study was to discover specific metabolites through fecal untargeted …
López-Suárez A, Santos-Sebastián M, Hernanz-Lobo A, Rincón-López E, Aguilera-Alonso D, et al.
Introduction Immune-based diagnostic tests for tuberculosis (TB) have suboptimal sensitivity in children and cannot differentiate between latent infection (LTBI) and active disease. This study evaluated the diagnostic potential of a broad range of biomarkers of tissue damage and …
Liu H, Dass SA, Wong MTJ, Balakrishnan V, Nordin F, et al.
…othesize the possible utility of the said antibody for both diagnostics and therapeutics of latent tuberculosis after more investigations with clinical samples.