Showing 1–25 of 200 documents
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Mayu Hikone, Yuya Kondo, Yu Takaizumi, Wataru Kagaya, Katharina Kranzer, et al.
**INTRODUCTION:** Current diagnostics for tuberculosis (TB) rely on sputum or site-specific specimen collection, posing critical limitations in certain populations. Urine has emerged as an alternative specimen, as demonstrated by urine lipoarabinomannan (LAM) testing. Beyond LAM,…
Margaret C Siu, Maria Selinopoulou, Susan Abarca Salazar, Jonathan P Sturgeon, Julie Huynh, et al.
…DS:** We systematically reviewed host-based gene expression diagnostics for pediatric EPTB. PubMed, Embase and Cochrane Library (January 1965-May 2025) were searched for studies in children (0-18 years) with EPTB. Exclusions were adult-only studies, mixed data on pulmonary TB and…
Hueda-Zavaleta M, Gomez de la Torre JC, Minchón-Vizconde D, Barletta-Carrillo C, Copaja-Corzo C, et al.
Background Molecular tests have contributed to reducing the mortality rate through early and accurate diagnosis of tuberculosis (TB). This is due to their low processing complexity and diagnostic accuracy superior to conventional methods. Objective To evaluate the diagnostic perf…
Anvita Gupta Malhotra, Leena Lokhande, Abhijit Pakhare, Payal Soni, Satya Prakash Vishwakarma, et al.
… These findings advocate for integrating advanced molecular diagnostics into routine tuberculosis workflows to reduce diagnostic delays and improve patient outcomes. **CLINICAL TRAIL NUMBER:** Not applicable.
Khalid Alyahyawi
…opic features, histopathological characteristics, molecular diagnostics, pharmacological therapy, and minimally invasive therapeutic interventions. Accurate diagnosis requires an integrated approach combining clinical assessment with imaging, endoscopic evaluation, and histopatho…
Jorge E Leiva-Ordoñez, Beatriz Quintero
Tuberculous meningitis is the most severe form of tuberculosis and remains associated with high mortality and substantial neurological disability, particularly among children and people living with HIV. Early diagnosis is challenging because of nonspecific clinical manifestations…
Barış Çil, Mehmet Sinan Bodur, Mehmet Kabak
**BACKGROUND:** The diagnosis of extrapulmonary tuberculosis (EPTB) often depends on advanced imaging, invasive tissue sampling, and multidisciplinary referral pathways. These complex, procedure-dependent diagnostic processes are particularly vulnerable to disruption during perio…
Meryem Sena Kaya, Sibel Yıldız Kaya, Rıdvan Karaali, Günay Can, İlker İnanç Balkan, et al.
**BACKGROUND:** Fever of unknown origin (FUO) remains a significant diagnostic challenge. Changes in patient populations and diagnostic technologies may shift the spectrum of underlying etiologies. This study aimed to examine recent FUO cases at a single tertiary center to identi…
Tandel N, Joseph AZ, Joshi A, Shrama P, Mishra RP, et al.
…formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a light on other nanoparticle-based molecular diagnostic approaches for TB. Despite the advent of science, we are yet to have a diagnostic tool that is simple, rapid, sensitive, …
Robert Needle, Yang Yu, Hafid Soualhine, Catherine Yoshida, Lei Jiao, et al.
…ycobacterial (NTM) infections is accomplished by three main diagnostics methods: smear microscopy, culture, and molecular testing. Diagnostic algorithms used by laboratories can significantly impact clinical and infection control management. Current Canadian Tuberculosis Standard…
Yuvarajan S, Praveen Radhakrishnan, Durga Krishnamurthy, Navya Cherukkumalli, Sagana Ravikumar
**BACKGROUND:** Sarcoidosis is a complex, multisystem granulomatous disease of unknown etiology, often presenting a diagnostic challenge due to its highly variable clinical manifestations and its overlap with infectious and neoplastic diseases. This is especially problematic in r…
G McNally, D Solomon, M Brown, S Capocci, D Creer, et al.
…y score, using results of mycobacterial cultures, molecular diagnostics, microscopy, histology, clinical and radiology results, to grade cases on a 1-5 scale. Since 2017, this has been routinely used as part of our quarterly patient Cohort Reviews. We evaluated the relationship b…
Sara Benevento, Niccolò Riccardi, Giovanni Fumagalli, Luigi Ruffo Codecasa, Giovanni Sotgiu
Tuberculosis (TB) remains a leading cause of infectious-disease-related morbidity and mortality worldwide, including in low-incidence, high-income countries, where cases increasingly cluster among vulnerable populations. In these settings, persistent diagnostic and treatment dela…
He H, Zou Y, He J, Bu H, Liu Y
It is very difficult to diagnose and distinguish tuberculous meningitis, and the current laboratory methods are unsubstantial in developing countries. The study is aimed at creating a scoring system on the basis of basic laboratory and clinical achievements that could be used as …
Yadav S, Rawal G, Jeyaraman M, Jeyaraman N
…p and the hurdles encountered with traditional tuberculosis diagnostics. From there, it traces the journey of the Xpert MTB/RIF technology, underscoring its molecular underpinnings. In this narrative review, the performance of the Xpert MTB/RIF Ultra system undergoes thorough scr…
Luo Y, Xue Y, Lin Q, Mao L, Tang G, et al.
Background The differential diagnosis between tuberculous meningitis (TBM) and bacterial meningitis (BM) remains challenging in clinical practice. This study aimed to establish a diagnostic model that could accurately distinguish TBM from BM. Methods Patients with TBM or BM were …
Fuyong Liu, Zheng Li, Xuejiao Li, Wei Hong, Yanlin Zhou, et al.
**OBJECTIVE:** We developed and validated a diagnostic scoring system for tuberculous meningitis (TBM) using 13 laboratory parameters, comparing tuberculous meningitis (TBM) and non-tuberculous meningitis (non-TBM). **METHODS:** This study enrolled patients diagnosed with mening…
Ria Winkelmann, Belana Blasczok, Melanie Winter, Peter Wild, Maria J G T Vehreschild, et al.
**INTRODUCTION:** Extrapulmonary tuberculosis (TB) and non-tuberculous mycobacterial (NTM) disease remain a diagnostic challenge and conventional methods such as mycobacterial culture or molecular methods (e.g. GeneXpert) performed on formalin-fixed paraffin embedded (FFPE) speci…
Hongxia Yan, Hongfei Duan, Xiaoxu Han, Jin Sun, Qingtao Liang, et al.
**INTRODUCTION:** Diagnosing tuberculosis (TB) in HIV-infected individuals presents significant challenges due to difficulties in obtaining specimens containing adequate quantities of(). This study aimed to evaluate the diagnostic performance of themRNA assay independently and in…
Hazratullah Bariz, Muhammad Haroon Stanikzai, Ghulam Mohayuddin Mudaser, Khalid Ahmad Stanikzai, Omid Dadras
**BACKGROUND:** Diagnostic delay among tuberculosis (TB) patients leads to late anti-TB treatment initiation, which is associated with poor prognosis and increased TB transmission. Despite its recognized negative consequences, diagnostic delay among TB patients is common in devel…
Le HN, Sriplung H, Chongsuvivatwong V, Nguyen NV, Nguyen TH
Introduction Tuberculous meningitis (TBM) is the most dangerous form of tuberculosis with high mortality and disability rates. However, the delayed diagnostic process is often due to the absence of the gold standard tests leading to a lack of information about the sensitivity and…
Walzl G, McNerney R, du Plessis N, Bates M, McHugh TD, et al.
…nts and key achievements in the search for new tuberculosis diagnostics and biomarkers. We highlight gaps and challenges in evaluation and rollout of new diagnostics and biomarkers, and prioritise areas needing further investment, including impact assessment and cost-benefit stud…
Yang Y, Qu XH, Zhang KN, Wu XM, Wang XR, et al.
Background: The discrimination of tuberculous meningitis and bacterial meningitis remains difficult at present, even with the introduction of advanced diagnostic tools. This study aims to differentiate these two kinds of meningitis by using the rule of clinical and laboratory fea…
Jose RA, Raja Inbaraj L, Catherine Vincent R, Baskar A, Mathew R
Background The diagnosis of Tuberculosis (TB) has been a challenge till the advent of rapid molecular diagnostic tests. The traditional diagnostic tests have its own limitations with regard to its performance or the turnaround time. Truenat MTB Plus assay, a battery-operated mole…
Olbrich L, Verghese VP, Franckling-Smith Z, Sabi I, Ntinginya NE, et al.
Background Childhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed to assess the diagnostic accuracy of the Cepheid Mycobacterium tube…