Showing 1–25 of 36 documents
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Raju R, Prasad BM, Alavadi U, Saini S, Sabharwal M, et al.
…has been transformed with the scaling-up of WHO-recommended diagnostics, but challenges remain with specimen transportation, completing diagnostic assessment, turnaround time (TAT), and maintaining laboratories. Private laboratories have demonstrated efficiencies for specimen col…
Agizew T, Boyd R, Auld AF, Payton L, Pals SL, et al.
Background Compared with smear microscopy, Xpert ® MTB/RIF has the potential to reduce delays in tuberculosis (TB) diagnosis and treatment initiation, and improve treatment outcomes. We reviewed publications comparing treatment outcomes of drug-susceptible TB patients diagnosed u…
Mbano IM, Mandizvo T, Rogich J, Kunota TTR, Mackenzie JS, et al.
…d lack of rapid, low-cost tuberculosis (TB) drug resistance diagnostics in low-income settings across the globe. It is these areas that are plagued with a disproportionately high disease burden and in greatest need of these diagnostics. Methods In this study, we compared the perf…
Nsawotebba A, Ibanda I, Mujuni D, Nabadda S, Nadunga D, et al.
Background Smear microscopy has remained the initial diagnostic test for presumptive tuberculosis (TB) patients in health facilities without the World Health Organization (WHO) recommended rapid diagnostic tools. In the Uganda TB laboratory network, the technique remains the only…
Dutta NK, Tornheim JA, Fukutani KF, Paradkar M, Tiburcio RT, et al.
…) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to analyze plasma metabolite profiles of Indian children with active TB (n = 16) and age- and sex-matche…
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong
Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control. An increasingly recognized and complex challenge is heteroresistance, the coexistence of drug-susceptible and drug-resista…
Chirenda J, Nhlema Simwaka B, Sandy C, Bodnar K, Corbin S, et al.
Background Insufficient cost data and limited capacity constrains the understanding of the actual resources required for effective TB control. This study used process maps and time-driven activity-based costing to document TB service delivery processes. The analysis identified th…
Van Wyk SS, Nliwasa M, Seddon JA, Hoddinott G, Viljoen L, et al.
Background Transmission of drug-resistant tuberculosis (DR-TB) is ongoing. Finding individuals with DR-TB and initiating treatment as early as possible is important to improve patient clinical outcomes and to break the chain of transmission to control the pandemic. To our knowled…
Oriekot A, Sereke SG, Bongomin F, Bugeza S, Muyinda Z
Background Tuberculosis (TB) is one of the leading causes of death worldwide. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and rifampicin-resistant (RR) pulmonary TB (PTB). This study aimed to compare the chest x-ray (CXR) patterns of microbiologic…
Nidoi J, Muttamba W, Walusimbi S, Imoko JF, Lochoro P, et al.
Background Tuberculosis (TB) is a major public health problem and at 48%, Karamoja in North-Eastern Uganda has the lowest treatment success rate nationally. Addressing the social determinants of TB is crucial to ending TB. This study sought to understand the extent and ways in wh…
Oladimeji O, Adepoju V, Anyiam FE, San JE, Odugbemi BA, et al.
Background The Lagos State Tuberculosis, Buruli Ulcer, and Leprosy Control Program (LSTBLCP) started engaging private hospitals under the Public-Private Mix (PPM) Program in 2008. The study aimed to evaluate the trend and predictors of successful Tuberculosis (TB) treatment outco…
van den Boom M, Bennani K, Sismanidis C, Gunneberg C, Khawaja L, et al.
…d treatment. Bacteriological confirmation using recommended diagnostics also requires further optimisation.
Gordhan BG, Peters JS, McIvor A, Machowski EE, Ealand C, et al.
…atory molecules may facilitate improvement of culture-based diagnostics for TB.
Le H, Nguyen N, Tran P, Hoa N, Hung N, et al.
Setting The tuberculous infection control strategy, FAST (Find cases Actively, Separate safely and Treat effectively), recommends prompt initiation of likely effective anti-tuberculosis treatment informed by Xpert ® MTB/RIF results . OBJECTIVE: To describe FAST implementation at …
Adepoju VA, Adelekan A, Etuk V, Onoh M, Olofinbiyi B
Introduction TB diagnosis and treatment practices among private providers not affiliated with the Nigeria National TB Program (NTP) have implications for TB control efforts. Studies evaluating these practices among non-NTP providers are scarce. We aimed to investigate TB diagnosi…
Chikovani I, Shengelia N, Marjanishvili N, Gabunia T, Khonelidze I, et al.
…Georgia National TB Programme (NTP). This paper presents TB diagnostics and treatment unit cost, their comparison with NTP tariffs and how the study findings informed TB financing policy. METHODS: Top-down (TD) and bottom-up (BU) mean unit costs for TB interventions by episode of…
Sarah Schmidiger, Damien Portevin
…of death from a single-infectious agent. Improved vaccines, diagnostics and treatment regimens for drug-susceptible and drug-resistant cases are paramount to attain the goals of the WHO's End TB Strategy. Our knowledge gap in protective immunity in TB impedes the development of s…
Ang MLT, Chan SM, Cheng LT, Cheong HY, Chew KL, et al.
…new advances in the clinical management of TB, ranging from diagnostics to new drugs and treatment regimens. The National TB Programme convened a multidisciplinary panel to update guidelines for the clinical management of drug-susceptible TB infection and disease in Singapore, co…
Khaing MNT, U N, Maw L, Arkar H, Naing SPP, et al.
Background The financial burden of tuberculosis (TB) can hinder patients and their families, creating obstacles throughout the care cascade, despite TB prevention and control being provided free of charge. In Myanmar, patients can visit private providers operating under public-pr…
Villalva-Serra K, Barreto-Duarte B, Miguez-Pinto JP, Queiroz ATL, Rodrigues MM, et al.
…s expanded use and further research into advanced molecular diagnostics for effective TB and DR-TB control. Funding FIOCRUZ.
Finlayson H, Lishman J, Palmer M
Purpose of review The current review identifies recent advances in the prevention, diagnosis, and treatment of childhood tuberculosis (TB) with a focus on the WHO's updated TB management guidelines released in 2022. Recent findings The COVID-19 pandemic negatively affected global…
Said B, Charlie L, Getachew E, Wanjiru CL, Abebe M, et al.
The lack of rapid, sensitive, and deployable tuberculosis diagnostic tools is hampering the early diagnosis of tuberculosis and early detection of treatment failures. The conventional sputum smear microscopy or Xpert MTB/RIF assay cannot distinguish between alive and dead bacilli…
Kakinda M, Tugumisirize D, Nyombi A, Mugisha M, Turyahabwe S, et al.
Background Uganda introduced Xpert® MTB/RIF assay into its TB diagnostic algorithm in January 2012. In July 2018, this assay was replaced with Xpert® MTB/RIF Ultra assay. We set out to compare the tests done and tuberculosis cases detected by Xpert® MTB/RIF and Xpert® MTB/RIF Ult…
Elias Jabbour, Marcia Pinto, Ricardo E Steffen, Fernanda Dockhorn, Daniele M Pelissari, et al.
**INTRODUCTION:** To eliminate tuberculosis (TB) in Brazil, scaling up screening and prevention strategies will be essential. We estimated costs of TB services in Brazil to support budgeting, cost-effectiveness analysis and inform the implementation of these strategies. **METHOD…
Muhammed S Bah, Kyaw Ko Ko Htet, Gregory P Bisson, Celso Khosa, Refiloe Masekela, et al.
Tuberculosis (TB) remains a major public health issue across the world and national TB guidelines are an important resource for diagnosis and treatment. This scoping review aimed to analyze how countries with the highest TB burdens approach the integration of comorbidity and risk…