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Ndwandwe DE, Runeyi S, Pienaar E, Mathebula L, Hohlfeld A, et al.
Background The Pan African Clinical Trials Registry (PACTR) is a WHO International Clinical Trials Registry Platform primary register, which caters for clinical trials conducted in Africa. PACTR is the first and, at present, the only member of the Network of WHO Primary Registers…
Park JJH, Grais RF, Taljaard M, Nakimuli-Mpungu E, Jehan F, et al.
…n this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with glo…
Grace AG, Mittal A, Jain S, Tripathy JP, Satyanarayana S, et al.
…up Specialized Register; the Central Register of Controlled Trials (CENTRAL), in the Cochrane Library; MEDLINE (PubMed); Embase; the Latin American Caribbean Health Sciences Literature (LILACS); Science Citation Index-Expanded; Indian Medlars Center; and the South Asian Database …
Ndwandwe D, Dube K, Mathebula L, Wiysonge CS
Clinical research is important in establishing the effects of health-care interventions. Vaccine clinical trials are to examine the effectiveness and safety of vaccines for the prevention of diseases. Africa has a high burden of infectious diseases such as malaria, tuberculosis, …
Chandra H, Rahman A, Yadav P, Maurya G, Kumar Shukla S
…randomized, double blind, parallel group, active controlled clinical trial. Newly diagnosed Vitamin D deficient pulmonary tuberculosis patients were randomly assigned to intervention group (received standard anti-tubercular treatment with adjunct Vitamin D3) and control group (re…
Strüver V, Ibeneme SC
Background The business of clinical research has changed in the past two decades, shifting from industrialised Western countries to so-called emerging markets such as Eastern Europe, Latin America and Africa. An appraisal of the trends could identify associated factors that may h…
Sara Domínguez-Rodríguez, David Lora, Alfredo Tagarro, Cinta Moraleda, Álvaro Ballesteros, et al.
**BACKGROUND:** The EMPIRICAL trial aims to assess safety and efficacy of an empirical treatment against cytomegalovirus (CMV) and tuberculosis (TB) compared to standard of care (SoC), on adverse events and 15-day and 1-year mortality among infants living with HIV hospitalized wi…
da Silva RE, Amato AA, Guilhem DB, de Carvalho MR, Novaes MRCG
…ual health needs. Objective: To map the global landscape of clinical trials run in Latin American and Caribbean countries and discuss the addressing of local health needs in the agenda of international clinical trials. Methods: The present study is a cross-sectional overview and …
M Munera-Campos, A González Quesada, M Espasandín Arias, M A Lasheras-Pérez, P de la Cueva Dobao, et al.
**BACKGROUND:** Randomized clinical trials (RCTs) supporting advanced treatments for atopic dermatitis (AD) involve highly selected patients, limiting their generalizability. **OBJECTIVE:** To determine the proportion of adults on advanced systemic therapy for AD in clinical pra…
Rojo P, Moraleda C, Tagarro A, Domínguez-Rodríguez S, Castillo LM, et al.
… is a Phase II-III, open-label randomized factorial (2 × 2) clinical trial, conducted in six African countries. The trial has four arms. Infants from 28 to 365 days of age HIV-infected and hospitalized with severe pneumonia will be randomized (1:1:1:1) to (i) SoC, (ii) valgancicl…
Kong Z, Liang N, Yang GL, Zhang Z, Liu Y, et al.
…ds We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, CENTRAL, MEDLINE Ovid, Embase Ovid, and seven other databases to 1 March 2019. We also searched the World Health Organization International Clinical Trials Registry Platform (www.who.int/ictrp), Clinical…
Wang Y, Yang JW, Yan SY, Lu Y, Han JG, et al.
… participants This multicenter, randomized, sham-controlled trial was conducted in China from October 12, 2020, through October 17, 2021. There was a 1:1 allocation using the dynamic block random method, and analyses were by intention to treat. Patients 18 years or older undergoi…
Kong Z, Liang N, Yang GL, Zhang Z, Liu Y, et al.
…ic searches of the Cochrane Hepato-Biliary Group Controlled Trials Register, CENTRAL, MEDLINE, Embase, LILACS, Science Citation Index Expanded, Conference Proceedings Citation Index - Science, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, an…
Wen Y, Li L, Deng Z
… and low 25(OH)D levels. Methods This randomized controlled clinical trial enrolled treatment-naïve patients with tuberculosis admitted to Zigong First People's Hospital (June 2016 to April 2017). The patients were grouped as the serum 25(OH)D ≥ 75 nmol/L (Normal-25(OH)D) and 25(…
Sinha S, Thukral H, Shareef I, Desai D, Singh BK, et al.
…se. Methods This randomized double-blind placebo-controlled trial was conducted in three sites in India. HIV negative participants aged 15-60 years with sputum smear positive PTB were recruited according to the Revised National Tuberculosis Control Program guidelines and were ran…
Mwansa-Kambafwile JRM, Chasela C, Levin J, Ismail N, Menezes C
…ving TB treatment initiation. A 3-arm randomized controlled trial (Standard of care-SOC, SMS technology or WBOTs) was conducted between September 2018 and April 2020. Newly diagnosed TB patients randomly allocated to SMS and WBOTs groups were sent reminder messages (text message …
Haraka F, Kakolwa M, Schumacher SG, Nathavitharana RR, Denkinger CM, et al.
…es (Web of Science). We also searched the WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, and the Pan African Clinical Trials Registry for ongoing trials. Selection criteria We included individual- and cluster-randomized trials, and before-after studies, …
Kolli SS, Kepley AL, Cline A, Feldman SR
… certolizumab pegol and apremilast, using phases III and IV clinical trial data. Expert opinion Even as treatment of psoriasis becomes safer, it is important to recognize both common and uncommon adverse effects of treatment. Common adverse effects are similar across treatment op…
Wickremsinhe MN, Little MO, Carter AS, Sullivan KA, Lyerly AD
…t women's own health needs are addressed, representation in trials of HIV preventives or treatments for comorbidities, and equitable study of newer medications during pregnancy. Methods We employed a keyword search of the International Clinical Trials Registry Platform to identif…
Kate Rich, Ronelle Burger, Andrew Boulle, Deanne Goldberg, Noxolo Gqada, et al.
…B Check. **DESIGN:** The study was a randomised controlled trial with a parallel design. **SETTING:** This study assessed mHealth support to boost TB testing in high-burden Cape Town clinics. **INTERVENTION:** Patients aged 18 or above with a valid mobile phone number that had…
Fan Wu, Suyin Huang, Ming Lei, Zhishan Deng, Qi Wan, et al.
**BACKGROUND:** Clinical trials have shown that glycopyrrolate/formoterol fumarate improves lung function in patients with chronic obstructive pulmonary disease (COPD) caused by tobacco exposure. Although tuberculosis-associated COPD has worse respiratory health outcomes than smo…
Kitenge M, Phiri B, Pheeha SM, Ogunrombi M, Nyasulu PS
…NE), EMBASE (OVID), Cochrane Central Register of Controlled Trials (CENTRAL), Scopus (Elsevier). We also searched Google Scholar along with trial registries and hand-searched the reference list of identified original research as well as review articles. Conference proceedings of …
Padmapriydarsini C, Mamulwar M, Mohan A, Shanmugam P, Gomathy NS, et al.
…monary tuberculosis (PTB). Methods In a randomized, 8-week, clinical trial, newly diagnosed, culture-positive PTB patients were randomized to standard ATT (HREZ = control arm) or standard ATT plus daily 1000 mg metformin (MET-HREZ = Metformin with Rifampicin [METRIF] arm) for 8 w…
Mathebula L, Mapahla L, Nurkhametova D, Ziganshina LE, Mazinu M, et al.
… to identify and describe ongoing, planned and completed TB trials conducted in the BRICS countries registered in WHO-International Clinical Trial Registry Platform (WHO-ICTRP); to report selective outcome reporting by comparing primary outcomes in published trials with their pre…
Martinson NA, Nonyane BAS, Genade LP, Berhanu RH, Naidoo P, et al.
… morbidity and mortality. We conducted a cluster-randomized trial of large urban and rural primary healthcare clinics in 3 provinces of South Africa to evaluate whether a novel intervention of targeted universal testing for TB (TUTT) in high-risk groups diagnosed more patients wi…