Showing 1–25 of 26 documents
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James J, Jamuna Rani R, Sathyanarayanan V, Sudha K
…is study, all Tuberculosis-related studies registered under Clinical Trial Registry of India from its inception in July 2007 to February 2021 were reviewed and analysed using the keyword ''Tuberculosis'' in the 'Trial Search' section. A total of 31,196 studies were registered in …
Cola JP, do Prado TN, Alves BMCS, Sales CMM, Borges BJP, et al.
…ts. Methods Pragmatic, randomized, non-blinded, multicenter clinical trial conducted in Brazil from January 2019 to December 2022. Subjects over the age of 18 years with an indication for TPT was included and those whose index case of active tuberculosis was in retreatment, multi…
Abraham Y, Assefa DG, Hailemariam T, Gebrie D, Debela DT, et al.
…ns. Methods We searched PubMed/MEDLINE, Cochrane Center for Clinical Trials (CENTRAL), Scopus, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, US Food and Drug Administration, and Chinese Clinical Trial Registry for primary articles published from 2013 to…
Nusrat Shafiq, Ashok Kumar, Vikram Vohra, Gopal Krishan Khuller, Manjula Singh, et al.
…multicentric, investigator-initiated, randomized controlled trial designed to assess the non-inferiority of a 16 week clofazimine-based regimen compared with the standard 24 week regimen for drug-susceptible pulmonary TB (Clinical Trials Registry of India no. CTRI/2019/03/018102)…
Du Y, Qiu C, Chen X, Wang J, Jing W, et al.
… reflecting superior antimicrobial activity against MDR-TB. Clinical trials registration Chinese Clinical Trial Registry ChiCTR 1800020391.
Sun W, Wu Z, Zhou Y, Xia F, Tang Q, et al.
…ld be expected to be developed into a short-course regimen. Clinical trials registration China Clinical Trial Registry ChiCTR-OPC-16009380.
Horne DJ, Kohli M, Zifodya JS, Schiller I, Dendukuri N, et al.
…n Health Sciences Literature, Scopus, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number Registry, and ProQuest, to 11 October 2018, without language restriction. Selection criteria Randomized trials, cross-secti…
Kohli M, Schiller I, Dendukuri N, Yao M, Dheda K, et al.
…atin American Caribbean Health Sciences Literature, Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number Registry, and ProQuest, 2 August 2019 and 28 January 2020 (Xpert Ultra studies), …
Ashwin Karnan, Ulhas Jadhav, Babaji Ghewade, Vivek Alone
…y with slightly better adherence in the shorter regimen. **CLINICAL TRIAL REGISTRATION:** The study was registered in the Clinical Trials Registry-India (Indian Council of Medical Research-National Institute of Medical Statistics), https://ctri.nic.in/, CTRI registration number …
Kay AW, González Fernández L, Takwoingi Y, Eisenhut M, Detjen AK, et al.
…dered age, disease severity, smear-test status, HIV status, clinical setting, specimen type, high tuberculosis burden, and high tuberculosis/HIV burden - For detection of rifampicin resistance, we considered multi-drug-resistant tuberculosis burden • To compare multiple Xpert MTB…
Wekesa C, Sekaggya-Wiltshire C, Muyanja SZ, Lume I, Nabaggala MS, et al.
…nducting a non-inferiority open-label randomized controlled trial to compare adherence to MDR-TB treatment among patients on self-administered therapy (measured by Medication Events Monitoring System (MEMS) technology) with a control group on DOT. Methods We plan to enrol 164 new…
Murphy-Okpala N, Eze C, Ossai EN, Agu CI, Ezenwosu I, et al.
…ia and similar settings in low-and middle-income countries. Trial registration Pan African Clinical Trial Registry PACTR202309676675265.
Bhargava A, Bhargava M, Meher A, Teja GS, Velayutham B, et al.
…ia. RATIONS is a field-based, cluster-randomised controlled trial evaluating the effect of providing nutritional support to household contacts of adult patients with microbiologically confirmed pulmonary tuberculosis in Jharkhand, India, on tuberculosis incidence. The patient coh…
Nida Khan, Muhammad Ahmar Khan, Naila Muzaffar, Ahmad Ismail, Abdul Ghafoor, et al.
…S:** This is a stepped wedge, cluster randomized controlled trial with economic evaluation and health related quality of life sub-studies. Modified all-oral 9-month regimen will be sequentially rolled-out compared with the standard all-oral 11-month regimen at 12 sites in Punjab,…
Zeliang Yang, Zichun Ma, Zubi Liu, Peibo Li, Yuqin Liu, et al.
…ormance of tNGS was robust regardless of specimen types and clinical symptoms. tNGS also showed a detection potential for other coinfecting respiratory pathogens. More than 90% of tNGS-positive individuals gained drug susceptibility results, which were mainly dependent on bacteri…
Inbaraj LR, Shewade HD, Daniel J, Srinivasalu VA, Paul J, et al.
… for the studies to be included were; randomized controlled trials or cohort studies that focused on adults with Isoniazid mono-resistant tuberculosis (HrTB) and treated with a Levofloxacin-containing regimen along with first-line anti-tubercular drugs; they should have had a con…
Giller DB, Giller BD, Giller GV, Scherbakova GV, Koroev VV, et al.
…d active TB absence verified with computed tomography (CT). Clinical improvement (sputum negativity, closure of caverna, and lack of reactivation for 3 years) was achieved in 81% of cases. Conclusions Comparing the successful results of this technique in the cohort of multidrug-r…
Franco JV, Bongaerts B, Metzendorf MI, Risso A, Guo Y, et al.
…ed) and WHO Global Index Medicus, and the WHO International Clinical Trials Registry Platform (ICTRP) on 3 May 2023 (date of last search for all databases); we placed no restrictions on the language of publication. Selection criteria We included retrospective and prospective coho…
Fox GJ, Nhung NV, Cam Binh N, Hoa NB, Garden FL, et al.
…esistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with drug-resistant tuberculosis are lacking. Methods We conducted a double-blind, randomized, controlled tri…
Schwab TC, Perrig L, Göller PC, Guebely De la Hoz FF, Lahousse AP, et al.
…ence Core Collection, Global Index Medicus, Google Scholar, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform for published and unpublished reports on targeted NGS for drug-resistant tuberculosis from Jan 1, 2005, to Oct 14, 2022, with updates to our…
Padmapriyadarsini C, Das M, Burugina Nagaraja S, Rajendran M, Kirubakaran R, et al.
…ods We conducted a literature search for randomized control trials, cohort studies, and case reports of chemoprophylaxis for pediatric contacts of MDR-TB patients in PubMed, EMBASE, Cochrane Databases of Systematic Reviews, metaRegister of Controlled Trials, and other clinical re…
Sweeney S, Gomez G, Kitson N, Sinha A, Yatskevich N, et al.
…mic evaluation (PRACTECAL-EE substudy) alongside an ongoing clinical trial (TB-PRACTECAL) aiming to assess the costs to patients and providers of new regimens, as well as their cost-effectiveness and impact on participant poverty levels. This substudy is based on data from the th…
Seddon JA, Garcia-Prats AJ, Purchase SE, Osman M, Demers AM, et al.
…y could reduce the risk of disease progression. To date, no trials of MDR-TB preventive therapy have been completed and World Health Organization guidelines suggest close observation with no active treatment. Methods The tuberculosis child multidrug-resistant preventive therapy (…
Nasur Buyinza, Kennedy Nkhoma, Eve Namisango, Matthew Maddocks, Julia Downing, et al.
…drug-resistant tuberculosis experience burdensome symptoms, clinical uncertainty, and high mortality. Palliative care is a designated essential health service under Universal Health Coverage. We aimed to test the hypothesis that receipt of additional nurse-led palliative care wou…
van den Elsen SH, Sturkenboom MG, Akkerman O, Barkane L, Bruchfeld J, et al.
…However, TDM is considered laborious and expensive, and the clinical benefit in MDR-TB has not been extensively studied. This observational multicentre study aims to determine the feasibility of centralised TDM and to investigate the impact of fluoroquinolone TDM on sputum conver…