Showing 1–12 of 12 documents
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Manjula Singh, Sindhu Joshi, Vikram Vohra, Rohit Sarin, Suchit Vasant Kamble, et al.
…ection, and immunogenicity. **DESIGN:** Phase 3 randomised clinical trial (PreVenTB trial). **SETTING:** 18 sites across six states of India. **PARTICIPANTS:** 12 717 healthy household contacts (aged ≥6 years) of patients with a smear positive TB test. **INTERVE…
Starke SJ, Martinez Rivera MB, Krishnan S, Shah M
…sis and management of latent tuberculosis infection (LTBI). Clinical practice guidelines and recommendations exist for LTBI management, but there is a need for innovative tools to improve medical students' and residents' knowledge of evidence-based practices for LTBI testing and …
Gao L, Zhang H, Xin H, Liu J, Pan S, et al.
…rganization's End TB Strategy.In this randomised controlled trial (Chinese Clinical Trial Registry identifier ChiCTR-IOR-15007202), two short-course regimens with rifapentine plus isoniazid (a 3-month once-weekly regimen and a 2-month twice-weekly regimen) were initially designed…
Lifan Zhang, Yujie He, Wenwen Wang, Lijun Wu, Xiaoxia Zuo, et al.
…cted a multicenter, open-label, randomized, non-inferiority trial at nine tertiary general hospitals in China. Eligible participants were adults (18-70 years) with high-risk rheumatic diseases and LTBI undergoing immunosuppressive therapy. Patients were randomized (1:1) to receiv…
Fernández-Ruiz M, Aguado JM
…ndications of available agents are reviewed, as well as the clinical evidence coming from clinical trials and observational registries. We discuss the impact of patient- and disease-related factors influencing the occurrence of infection. Finally, strategies for risk minimization…
Gong X, He Y, Zhou K, Hua Y, Li Y
…ntly improve the accuracy of tuberculosis (TB) detection in clinical settings, with advanced sensitivity and specificity. Early detection of TB can be challenging, but Xpert has improved the efficacy of the diagnostic process. Nevertheless, the accuracy of Xpert varies according …
Hirabayashi R, Nakayama H, Yahaba M, Yamanashi H, Kawasaki T
…IGRAs may be useful for detecting TB infection in children. Clinical trial registration The review protocol was prospectively registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000046737).
Fu L, Feng Y, Ren T, Yang M, Yang Q, et al.
…ever studied for LTBI. This proof-of-concept study (Chinese Clinical Trials Registry number: ChiCTR2200058346) was the first to explore a novel, rapid, and simple LTBI detection method via breath test on high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS…
Jonas DE, Riley SR, Lee LC, Coffey CP, Wang SH, et al.
…USPSTF). Data sources PubMed/MEDLINE, Cochrane Library, and trial registries through December 3, 2021; references; experts; literature surveillance through January 20, 2023. Study selection English-language studies of LTBI screening, LTBI treatment, or accuracy of the tuberculin …
Crowley JJ, Warren RB, Cather JC
…ata from randomized, placebo- and active-controlled phase 3 clinical trials show tildrakizumab, guselkumab and risankizumab to have a favourable risk-benefit profile in patients with moderate to severe psoriasis. No significant safety concerns have been observed for any of these …
Oxlade O, Trajman A, Benedetti A, Adjobimey M, Cook VJ, et al.
…able and highly dependent on the setting. We have planned a trial of a standardised public health approach to strengthen the management of household contacts (HHCs) of newly diagnosed patients with pulmonary TB. Assessing costs related to approach is a secondary objective of the …
Yanes-Lane M, Trajman A, Bastos ML, Oxlade O, Valiquette C, et al.
…scade of care for latent TB infection. A cluster randomized trial of a programmatic public health intervention to improve management of latent TB infection in household contacts was conducted in Rio de Janeiro. Interventions included contact registry, initial and in-service train…