Showing 1–10 of 10 documents
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Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, et al.
…ent in children is largely extrapolated from adult studies. Trials in adults with smear-negative tuberculosis suggest that treatment can be effectively shortened from 6 to 4 months. New paediatric, fixed-dose combination anti-tuberculosis treatments have recently been introduced …
Naidoo A, Dooley KE, Naidoo K, Padayatchi N, Yende-Zuma N, et al.
…phase 2b, open-label, non-comparative randomised controlled trial to assess the antiretroviral activity of a fixed-drug, single tablet, combination of bictegravir (BIC) 50 mg/emtricitabine (FTC) 200 mg/tenofovir alafenamide (TAF) 25 mg (Biktarvy). The primary objective is to dete…
Cattamanchi A, Crowder R, Kityamuwesi A, Kiwanuka N, Lamunu M, et al.
…s We conducted a pragmatic stepped-wedge cluster-randomized trial including all adults treated for drug-susceptible pulmonary TB at 18 health facilities across Uganda over 8 months (1 December 2018-31 July 2019). Facilities were randomized to switch from routine (control period) …
Tadesse AW, Mohammed Z, Foster N, Quaife M, McQuaid CF, et al.
…gn We will conduct a pragmatic three-arm cluster-randomised trial with 78 health facilities in two regions in Ethiopia. Facilities are randomised (1:1:1) to either of the two intervention arms or standard of care. Adults aged ≥ 18 years with drug-sensitive (DS) pulmonary TB are e…
Mgcini Moyo, Thobani Ntshiqa, Yohhei Hamada, Andrew Copas, Issa Sabi, et al.
…lines. **METHODS:** This is a pragmatic cluster-randomised trial conducted in Lesotho and Tanzania. Drug-sensitive TB (DS-TB) index patients aged ≥ 18 years, who have at least one contact, will be enrolled if they are microbiologically confirmed with TB…
Qian Lei, Hao Wang, Liyun Dang, Xiaohui Lv, Xuejiao Zhou, et al.
…in (RFP) in drug-susceptible TB patients, and to assess its clinical effectiveness and safety through a pragmatic randomized controlled trial (PRCT). **METHODS:** A total of 489 TB patients undergoing first-line anti-TB treatment were enrolled and randomly assigned to a pha…
Aisya Rezki Noeriman, Sumarheni Sumarheni, Aliya Nur Hasanah, Lika Apriani, Prayudi Santoso, et al.
…B) treatment remains limited. This scoping review evaluated clinical studies on TDM and its impact on TB treatment outcomes. **METHODS:** A scoping review was performed using a systematic search in PubMed, Embase, Web of Science, ClinicalTrials.gov, and the World Health Organiza…
Shangguan Y, Guo W, Feng X, Shi Y, Li X, et al.
… is unclear. Methods We conducted an open-label, randomized trial in China, involving newly diagnosed, drug-susceptible pulmonary TB. The control group was treated with the standard 6-month regimen. The experimental group replaced ethambutol with faropenem for 2 months. The prima…
Maraba N, Orrell C, Chetty-Makkan CM, Velen K, Mukora R, et al.
…andard of care clinics will be conducted. Significance This trial will provide evidence for the use of an intervention, including medication monitors and differentiated care package, to improve adherence to TB treatment. Improved adherence should also improve TB treatment complet…
Solans BP, Béranger A, Radtke K, Mohamed A, Mirzayev F, et al.
…les were screened. We searched PubMed, EMBASE, CENTRAL, and trial registries from 2010 to 2021. We included studies in children aged Results Of 304 studies identified, 46 were eligible for full-text review, and 12 and 18 articles were included for the efficacy and PK analyses, re…