Showing 1–25 of 51 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Jeyachandran DS, Pusam Y
…how these insights could catalyze the development of future vaccines. The current landscape of novel vaccine development for TB is illuminated, including a spotlight on the latest vaccine candidates.
Srivastava S, Dey S, Mukhopadhyay S
…nd impacted by the inefficacy of drugs, absence of advanced vaccines, misdiagnosis improper treatment, and social stigma. The BCG vaccine provides partial effectiveness in demographically distinct populations and the prevalence of multidrug-resistant (MDR) and extensively drug-re…
Bidyarani Devi Konjengbam, Heikrujam Nilkanta Meitei, Anupama Pandey, Reena Haobam
… and its preclinical and clinical trials. Additionally, DNA vaccines and their vaccination techniques are also discussed. Furthermore, the immunoinformatics approach and nanomaterial-based vaccine delivery with practical and productive endpoints are also discussed. Lastly, the po…
Khan MT, Mahmud A, Islam MM, Sumaia MSN, Rahim Z, et al.
…culosis. Therefore, it is urgently necessary to develop new vaccines to prevent infections caused by these strains. We used a subtractive proteomics approach on 23 virulent Mtb strains and identified a conserved membrane protein (MmpL4, NP_214964.1) as both a potential drug targe…
Ahmed M, Farris E, Swanson RV, Das S, Yang Y, et al.
…s, there is an urgent need for the design of more effective vaccines against TB. The development of safe and novel adjuvants for human use is critical. In this study, we demonstrate that saponin-based TQL1055 adjuvant when formulated with a TLR4 agonist (PHAD) and Mtb specific im…
Chae H, Shin SJ
…e Mtb complex strains are required for development of novel vaccines and for control of MDR/XDR Mtb infection, eventually leading to refinement of treatment regimens and the health care system. Many studies have focused on the differential identification of Mtb complex strains be…
Mohammadzadeh R, Ghazvini K, Farsiani H, Soleimanpour S
…m, which emphasises the design and development of efficient vaccines and diagnostic biomarkers. Extracellular vesicles (EVs) secretion is a conserved phenomenon in all the domains of life. Various cargos such as nucleic acids, toxins, lipoproteins, and enzymes have been recognise…
Mata-Espinosa D, Lara-Espinosa JV, Barrios-Payán J, Hernández-Pando R
…nary Mtb transmission to close contacts. We also review new vaccines that deliver Mtb antigens via particle- or virus-based vectors and trigger protective immune responses. The results obtained in this type of research suggest that this is an alternative therapy that has the pote…
Fang Y, Wang F, Jiang T, Duan J, Huang T, et al.
Mpox is a zoonotic infectious disease caused by the mpox virus (MPXV). Historically, the majority of mpox cases have been documented in Central Africa. However, since May 2022, there has been a notable rise in reported cases from regions beyond Africa. Currently, over 110 countri…
Singh Dewhare S
…ntial for the development of more effective drug molecules, vaccines and may help in devising new strategy for containing and eradicating TB.
Minakshi P, Ghosh M, Brar B, Kumar R, Lambe UP, et al.
… on developments regarding nanoparticle-based therapeutics, vaccines and diagnostic methods developed or under pipeline with their potential benefits and limitations to combat mycobacterial diseases for their successful eradication from the world in future. Results Distinct morph…
Wang DM, Li QF, Zhu M, Wu GH, Li X, et al.
Background Sichuan is a province located in southwestern China, which have a higher incidence of tuberculosis (TB). This study aimed to analyze the epidemiological and clinical characteristics, as well as drug resistance in culture-confirmed children with Tuberculosis meningitis …
La Manna MP, Orlando V, Tamburini B, Badami GD, Dieli F, et al.
Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of multidrug-resistant and extensively drug-resistant TB is making control of TB more difficult. Mycobacterium bovis bacillus …
Xu Y, Li Q, Zhu M, Wu X, Wang D, et al.
The aim of this study was to investigate the epidemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China.From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years…
Hao L, Ma J, Shi C, Lin X, Zhang Y, et al.
…ods: Recombinant adenovirus type 5 (rAd5) based therapeutic vaccines rAdhGLi and rAdhGLs (rAds) were respectively developed to express intracellular and extracellular granulysin. The ex vivo bactericidal effects of rAdhGLi and rAdhGLs were evaluated on U937 and RAW264.7 cells. Th…
Marimani M, AlOmar SY, Aldahmash B, Ahmad A, Stacey S, et al.
Background Mycobacterium tuberculosis (Mtb) is an airborne pathogenic microorganism that causes tuberculosis (TB). This pathogen invades lung tissues causing pulmonary infections and disseminates into other host organs. The Bacillus Calmette-Guérin (BCG) vaccine is employed to pr…
Chin KL, Anibarro L, Chang ZY, Palasuberniam P, Mustapha ZA, et al.
Tuberculosis (TB) is the world's second-deadliest infectious disease. Despite the availability of drugs to cure TB, control of TB is hampered by the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). The presence of MDR/XD…
Swinkels HM, Jilani TN, Tobin EH
…ics. Researchers are developing promising candidates for TB vaccines that can prevent the progression to TB disease. In the United States (US), the TB Centers of Excellence provide readily available expert advice to clinicians. Civil societies, patients, stakeholders, and advocac…
Emmama Jamil, Muhammad Majid Aziz, Afreenish Amir, Brian Godman, Stephen M Campbell, et al.
**BACKGROUND/OBJECTIVES:** Community-acquired pneumonia (CAP) imposes a significant health burden among low- and middle-income countries. The burden is exacerbated by antimicrobial resistance (AMR), often due to inappropriate antibiotic agent use and gaps in antimicrobial steward…
Kenneth W Foreman, Hui-Chen Foreman
Tuberculosis (TB), primarily caused by(Mtb), remains a leading cause of infectious disease mortality worldwide. Global TB control efforts face several hurdles, including the lack of a broadly effective vaccine, limited sensitivity of current diagnostics, particularly for paucibac…
Rojano B, Caminero JA, Hayek M
…-of-care testing, rapid detection of drug resistance, novel vaccines, and new prophylaxis and treatment regimens (particularly for MDR and XDR TB). The ultimate objective of those programs is to develop highly effective drug regimens that can achieve high cure rates regardless of…
Md Zamiur Rahaman, Tahmina Alam, Syeda Shamsun Nahar, Ridwana Nahrin, Israt Jahan Bushra, et al.
**OBJECTIVE:** This scoping review aims to identify and map the available evidence on interventions for the prevention and treatment of childhood TB, confirm current practice, explore variation, and identify emerging approaches. **STUDY DESIGN:** Scoping review. **METHOD:** Thi…
Pulak Pritam, Sreelipta Das, Sandeep Kumar Behera, Monali Sahoo, Lopamudra Subudhi, et al.
The disease tuberculosis, caused by, is one of the leading causes of global human mortality. The rise of multidrug and extensively drug-resistant strains of the pathogen and the limited efficacy of the BCG vaccine is one of the major concerns worldwide. Conventional chemotherapy …
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…olds promise for the development of innovative diagnostics, vaccines, and antiadhesin therapies aimed at combating both drug-sensitive and drug-resistant tuberculosis.
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…ng years of progress. Despite the availability of effective vaccines and treatment regimens, gaps in awareness, funding, healthcare infrastructure, and social determinants of health hinder global elimination efforts. Coordinated, multisectoral strategies are essential to address …