Showing 1–25 of 132 documents
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Gupta N, Garg S, Vedi S, Kunimoto DY, Kumar R, et al.
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis ( Mtb ), kills 5,000 people per day globally. Rapid development and spread of various multi drug-resistant strains of Mtb emphasize that an effective vaccine is still the most cost-effectives and effici…
Khalid K, Poh CL
…c resistance crisis. To address this issue, next-generation vaccines are being developed to prevent antimicrobial resistance caused by MDR bacteria. Traditional vaccine platforms, such as inactivated vaccines (IVs) and live attenuated vaccines (LAVs), were effective in preventing…
Gregor Nosan, Andreja Cerkvenik Škafar
…s to modernize TB prevention while awaiting next-generation vaccines and may serve as a guide for other low-incidence countries.
Rappuoli R, Black S, Bloom DE
Most vaccines for diseases in low- and middle-income countries fail to be developed because of weak or absent market incentives. Conquering diseases such as tuberculosis, HIV, malaria, and Ebola, as well as illnesses caused by multidrug-resistant pathogens, requires considerable …
Weerasuriya CK, Harris RC, McQuaid CF, Bozzani F, Ruan Y, et al.
…rough the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the epidemiologic impact, cost-effectiveness, and budget impact of hypothetical novel prophylactic p…
Day TA, Penn-Nicholson A, Luabeya AKK, Fiore-Gartland A, Du Plessis N, et al.
Background A therapeutic vaccine that prevents recurrent tuberculosis would be a major advance in the development of shorter treatment regimens. We aimed to assess the safety and immunogenicity of the ID93 + GLA-SE vaccine at various doses and injection schedules in patients with…
Qu W, Guo Y, Xu Y, Zhang J, Wang Z, et al.
…re has been significant progress in developing tuberculosis vaccines, such as improved BCG vaccine, subunit vaccine, DNA vaccine, live attenuated vaccine and inactivated vaccine. Among these candidate vaccines, there are some promising vaccines to improve or replace BCG vaccine e…
Huimin Chen, Ye Gu, Lei Song, Lihui Si
…bacterial infections has exacerbated the need for effective vaccines to prevent these hard-to-treat pathogens. Traditional vaccine approaches have achieved tremendous successes but often fall short for pathogens like(TB), which evades host immunity through complex mechanisms, and…
Tovar M, Sanz J, Moreno Y
…s 2B and 3 of the development pipeline. The impact of these vaccines on the general population needs to be addressed using disease-transmission models, and, in a country like China, which last year ranked third in number of cases worldwide, and where the population is aging at a …
Sandip Patil, Indu Singh, Indira Kumari Verma, Anil Kumar, Juhi Sharma, et al.
…ttracted the attention of scientific communities to revisit vaccines as a potential candidate against these superbugs. Although vaccines dedicated to bacterial infections are substantially reducing antibiotic use and decreasing annual healthcare expenditures for drug-resistant in…
Soleimanpour S, Yaghoubi A, Sadat Seddighinia F, Rezaee SAR
…radicate TB by 2050. Over the last few decades, 23 novel TB vaccines have entered into clinical trials, more than 13 new vaccines have reached various stages of preclinical development, and more than 50 potential candidates are in the discovery stage as next-generation vaccines. …
An Y, Ni R, Zhuang L, Yang L, Ye Z, et al.
… strains underscores the pressing need for more efficacious vaccines and treatments. This review meticulously maps out the contemporary landscape of TB vaccine development, with a focus on antigen identification, clinical trial progress, and the obstacles and future trajectories …
Faysal MA, Tanni FY, Rahman MM, Rahman MA, Chowdhury MSR, et al.
…formatics-driven approaches in developing effective subunit vaccines against bTB, providing a foundation for experimental validation and future applications in combating this pervasive zoonotic disease, bovine tuberculosis.
Khan Z, Ualiyeva D, Amissah OB, Sapkota S, Hameed HMA, et al.
…ug-resistant (XDR) TB requires the evolution of more potent vaccines. Therefore, this research aims to generate a universal TB subunit vaccine using advanced immunoinformatics techniques. In generating a novel multiepitope subunit vaccine, we selected the conserved and experiment…
Leung-Theung-Long S, Coupet CA, Gouanvic M, Schmitt D, Ray A, et al.
Despite the existence of the prophylactic Bacille Calmette-Guérin (BCG) vaccine, infection by Mycobacterium tuberculosis (Mtb) remains a major public health issue causing up to 1.8 million annual deaths worldwide. Increasing prevalence of Mtb strains resistant to antibiotics repr…
Gong W, Liang Y, Wu X
… multi-drug resistant (MDR) HIV strain related coinfection. Vaccines play a key role in the prevention and control of infectious diseases. Unfortunately, the only licensed preventive vaccine against TB, bacilli Calmette-Guérin (BCG), is ineffective for prevention of pulmonary TB …
Kousha A, Farajnia S, Ansarin K, Khalili M, Shariat M, et al.
Several explanations have been suggested concerning the variety in bacille Calmette-Guerin (BCG) vaccine efficacy on strains of Mycobacterium tuberculosis (Mtb). This study aimed to compare the effect of BCG vaccination history in the prevention of the occurrence of Mtb-Beijing a…
Shah P, Mistry J, Reche PA, Gatherer D, Flower DR
…sistant forms of M. tuberculosis, the need for effective TB vaccines becomes imperative. Currently, the only licensed TB vaccine is Bacillus Calmette-Guérin (BCG). Yet, BCG has many drawbacks limiting its efficacy and applicability. We applied advanced computational procedures to…
Hongmin Kim, Jong-Seok Kim, Kee Woong Kwon, Woo Sik Kim, Minchul Park, et al.
… whether the adoptive transfer of dendritic cell (DC)-based vaccines pulsed with culture filtrate antigens (CFA) of Mycobacterium tuberculosis (Mtb) could enhance BCG efficacy and support anti-TB drug therapy. **RESULTS:** In BCG-vaccinated mice, adoptive transfer of CFA-pulsed …
Eva Akurut, Yahaya Gavamukulya, Julius Mulindwa, Moses Isiagi, Ronald Galiwango, et al.
…, necessitates an urgent need for developing more effective vaccines. This study employed an in-silico approach to design a multi-epitope vaccine targeting the PE_PGRS16 protein, a conserved virulence factor found across both species, including drug-resistant strains. PE_PGRS16 w…
Yadav J, Verma S, Chaudhary D, Jaiwal PK, Jaiwal R
…e being trailed for the development of effective and potent vaccines like mucosal- and epitope-based vaccines, which may replace BCG or boost BCG responses. The use of nanotechnology for diagnosis and treatment of TB is also in the pipeline along with many other vaccines, which a…
Nichola R Naylor, Mateusz Hasso-Agopsowicz, Chaelin Kim, Yixuan Ma, Isabel Frost, et al.
…biotic-resistant infections and the potential for bacterial vaccines to mitigate this burden. **METHODS:** We take healthcare system and labour productivity perspectives. Hospital cost-per-case and length-of-stay estimates were calculated through meta-analyses and reviewing publ…
Manu Sharma, Sher Afghan, Amit Singh, Iqbal Alam, Meetu Agarwal, et al.
Tuberculosis (TB), caused by(), affects one-third of humanity. Despite the availability of effective drug regimens, complete eradication ofremains challenging due to prolonged treatment duration. Additionally, MDR-TB and co-infection with HIV further exacerbate disease severity. …
Maltezou HC, Magaziotou I, Tseroni M, Syrigonaki K, Syrogiannopoulos GA, et al.
In 2016 a Βacillus Calmette-Guérin vaccination policy targeting high-risk neonates for tuberculosis before discharge from maternity hospital was adopted in Greece. Vaccination rates were 38.2% in 2019 and 24.7% in 2020. Vaccination coverage varied by risk group (higher for neonat…
da Costa C, Benn CS, Nyirenda T, Mpabalwani E, Grewal HMS, et al.
…ease, is essential to ensure universal access to quality TB vaccines, regardless of their background or personal circumstances.