Showing 1–25 of 200 documents
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Hu Z, Lu SH, Lowrie DB, Fan XY
…l. Recently, the development of highly efficacious COVID-19 vaccines within one year accelerated the vaccine development process in human use, with the notable example of mRNA vaccines and adenovirus-vectored vaccines, and increased the public acceptance of the concept of the con…
Harris RC, Sumner T, Knight GM, Evans T, Cardenas V, et al.
…d largest number of cases worldwide. New tools, such as new vaccines, are needed to meet WHO tuberculosis goals. Tuberculosis vaccine development strategies mostly target infants or adolescents, but given China's ageing epidemic, vaccinating older people might be important. We mo…
Zhou F, Zhang D
…gress has been made in research and development (R&D) of TB vaccines in the past decades, and a dozen vaccine candidates, including live attenuated mycobacterial vaccines, killed mycobacterial vaccines, adjuvanted subunit vaccines, viral vector vaccines, and messenger RNA (mRNA) …
Schön M, Heesemann E, Ebert C, Subramanyam M, Vollmer S, et al.
…and multivariable logistic regression models were used. The vaccines included targeted tuberculosis, hepatitis B, polio, diphtheria/pertussis/tetanus (DPT) and measles. Moreover predictors for perinatal health care uptake were analysed by multivariable logistic regression. Of the…
Tom Sumner, Rebecca A Clark, Tomos O Prys-Jones, Roel Bakker, Gavin Churchyard, et al.
…ity and mortality in people living with HIV (PLHIV). New TB vaccines may help reduce this burden. There is limited data on the response to new TB vaccines in PLHIV and how this may vary with levels of immunosuppression and anti-retroviral therapy (ART). The potential interaction …
Zsofia M Hesketh, Rebecca A Clark, Rupali Limaye, Puck T Pelzer, Shaun Palmer, et al.
…ential barrier to the introduction of new tuberculosis (TB) vaccines. In the absence of TB-specific vaccine confidence surveys, analysis of general national vaccine confidence data can provide a useful proxy to determine where demand generation strategies may need to be focused a…
Gupta N, Garg S, Vedi S, Kunimoto DY, Kumar R, et al.
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis ( Mtb ), kills 5,000 people per day globally. Rapid development and spread of various multi drug-resistant strains of Mtb emphasize that an effective vaccine is still the most cost-effectives and effici…
Faust L, Schreiber Y, Bocking N
Background Bacille Calmette-Guérin (BCG) vaccination against tuberculosis (TB) is widespread in high-TB-burden countries, however, BCG vaccination policies in low-burden countries vary. Considering the uncertainties surrounding BCG efficacy and the lower likelihood of TB exposure…
Quincer EM, Gobezayehu AG, Belew ML, Endalamaw LA, Tesfaye YA, et al.
…World Health Organization. We assessed the acceptability of vaccines currently administered during pregnancy [tetanus, diphtheria and COVID-19] and willingness to receive a new TB vaccine during pregnancy and/or lactation among Ethiopian women. Methods From January to February 20…
Kanipe C, Boggiatto PM, Putz EJ, Palmer MV
Mycobacterium bovis ( M. bovis ) is the zoonotic bacterium responsible for bovine tuberculosis. An attenuated form of M. bovis , Bacillus Calmette-Guerin (BCG), is a modified live vaccine known to provide variable protection in cattle and other species. Protection for this vaccin…
Adetokunboh OO, Ndwandwe D, Awotiwon A, Uthman OA, Wiysonge CS
…ase-control studies that have efficacy and effectiveness of vaccines in HIV-infected and HIV-exposed children as outcomes. Web of Science, Cochrane Library, PubMed and Scopus databases were searched for articles. Efficacy of 9-valent pneumococcal conjugate vaccine (PCV9) against …
Haley M Sterle, Ellie J Putz, Mitchell V Palmer, Steven C Olsen, Paola M Boggiatto
**INTRODUCTION:** and, the causative agents of bovine brucellosis and tuberculosis respectively, are zoonotic bacterial pathogens that both contribute to major economic losses in the cattle industry and pose a human health risk worldwide. Co-infections of cattle withandhave been …
Clark RA, Weerasuriya CK, Portnoy A, Mukandavire C, Quaife M, et al.
…n tuberculosis cases and 506 thousand deaths in 2021. Novel vaccines effective in adolescents and adults could reduce this burden. M72/AS01 E and BCG-revaccination have recently completed phase IIb trials and estimates of their population-level impact are needed. We estimated the…
Yamoah P, Mensah KB, Padayachee N, Bangalee V, Oosthuizen F
The BCG vaccine, like all other vaccines, is associated with adverse events following immunization (AEFI). Reducing the incidence of AEFI is crucial in reposing confidence in BCG vaccination and reducing hesitancy associated with the vaccine. This requires safety precautions befo…
Kochhar S, Barreira D, Beattie P, Cavaleri M, Cravioto A, et al.
… or systematic approaches exist to inform developers of new vaccines of the evidence anticipated to facilitate global policy recommendations, before a vaccine candidate approaches regulatory approval at the end of pre-licensure efficacy studies. Consequently, significant delays m…
Speth F, Hinze CH, Andel S, Mertens T, Haas JP
Background The goal of this study was to apply the varicella zoster virus (VZV) vaccine to patients with pediatric rheumatic diseases (PRD) at risk for severe chickenpox, without interrupting their current immunosuppression, including biological agents, using an immunological-bas…
Lee S, Kim T, Seong KY, Yim SG, Lee WK, et al.
…r 8 weeks at -20 °C. In vivo vaccination tests using BCG-MN vaccines on guinea pigs exhibited no adverse reactions. Moreover, the BCG-MN vaccine demonstrated superior immune response compared to injections, suggesting that this BCG vaccine-coated MN platform has the potential as …
Machlaurin A, Pol SV, Setiawan D, van der Werf TS, Postma MJ
…s effectiveness is limited and varies by age. New candidate vaccines are currently being investigated. In response to the declining incidence of TB, practices relating to BCG vaccination have changed in various countries in recent years. A valid cost-effectiveness study is theref…
Penn-Nicholson A, Tameris M, Smit E, Day TA, Musvosvi M, et al.
Background A vaccine that prevents pulmonary tuberculosis in adults is needed to halt transmission in endemic regions. This trial aimed to assess the safety and immunogenicity of three administrations at varying doses of antigen and adjuvant of an investigational vaccine (ID93 + …
Augustinas Stasiūnas, Jurgita Stasiūnienė, Enrika Didžiulienė
…-rapid seroconversion. Understanding this BCG and influenza vaccines interaction is crucial for healthcare providers to differentiate between benign post-vaccination reactions and those that may require further clinical evaluation.
Valizadeh A, Khosravi A, Sedighian H, Behzadi E, Gholami Parizad E, et al.
Background & objective Despite the vaccination with the BCG vaccine, tuberculosis (TB) remains one of the major health problems in the world. The aim of this study was to evaluate our newly designed vaccine using IL-22 as an adjuvant in comparison with the common BCG vaccine. Met…
Hope JC, Khalid H, Thom ML, Howard CJ, Shaw DJ
Mycobacterium bovis , the causative agent of bovine tuberculosis (bTB), is a globally prevalent pathogen with significant animal welfare, economic and public health impacts. In the UK, the control of bTB relies on detection via tuberculin skin tests with ancillary interferon gamm…
Bassoum O, Sougou NM, Ba MF, Anne M, Bocoum M, et al.
Background In Senegal, studies focusing specifically on vaccination coverage with the Bacille de Calmette et Guérin (BCG) vaccine, the birth dose of oral polio vaccine (OPV zero dose) and the birth dose of hepatitis B (HepB-BD) vaccine are insufficient. This study aimed to highli…
Hu Z, Jiang W, Gu L, Qiao D, Shu T, et al.
…e antigen-specific T cell responses induced by the separate vaccines. The SeV85AB-DNA immunization regimen induced higher levels of recall T cell responses after Mtb infection and conferred better immune protection compared with DNA-SeV85AB or a single immunization. Collectively,…
James T Gordy, Rowan E Bates, Elizabeth Glass, Jacob Meza, Yangchen Li, et al.
Tuberculosis disease (TB) caused by Mycobacterium tuberculosis (Mtb) bacteria remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the Mtb infection. Bacterial persistence during …