Showing 1–25 of 60 documents
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Tola A, Mishore KM, Ayele Y, Mekuria AN, Legese N
…major global health challenges in the twenty-first century. TB-HIV co-infected people are facing multifaceted problems like high lost to follow up rates, poor treatment adherence, high TB recurrence rate, and high mortality risk. Our objective was to assess the outcomes of TB tre…
Solange Mudih Ngala, Disline Manli Tantoh, Oswald Ndi Nfor, Gamo Djouomo Francis, Adeline Fitame, et al.
…ng impacts across age cohorts. Evaluating tuberculosis (TB) treatment outcomes, especially among HIV patients across different age groups, is crucial for effective TB management. This study assessed the age-specific relationship between HIV status and TB treatment outcomes among …
Mekonen H, Negesse A, Dessie G, Dessie G, Desta M, et al.
…spite the implementation of a short-term direct observation treatment programme, HIV coinfection is one of the main determinants of tuberculosis (TB) treatment success. This meta-analysis was conducted to report the impact of HIV on TB treatment outcomes using inconsistent and va…
Sukesha Gamit, Mohamed Anas Mohamed Faruk Patni, Hiteshree Patel, Chintan Gamit, Jayendrakumar Kosambiya
**BACKGROUND:** Human immunodeficiency virus-tuberculosis coinfection represents a major public health problem, especially in resource-poor countries like India. This mixed-method study explores the epidemiological and clinical characteristics, including treatment outcomes of HIV…
Moges S, Lajore BA
…is a major public health problem in Ethiopia. Patients with TB-HIV co-infection have significantly higher mortality rates compared to those with TB or HIV mono-infection. This systematic review and meta-analysis aim to summarize the evidence on mortality and associated factors am…
Hoerter A, Arnett E, Schlesinger LS, Pienaar E
…y between Mycobacterium tuberculosis ( Mtb ) and HIV during coinfection include: disruption of cytokine balances, impairment of innate and adaptive immune cell functionality, and Mtb -induced increase in HIV viral loads. Tuberculosis granulomas are the interface of host-pathogen …
Md Abdul Kuddus, Sazia Khatun Tithi, Anip Kumar Paul, Thitiya Theparod
… This dual burden exacerbates disease severity, complicates treatment strategies, and increases mortality rates. In this study, we developed a mathematical model of TB-HIV co-infection to examine the dynamics of TB prevalence, HIV prevalence, co-infection prevalence and combined …
Osei Bonsu E, Addo IY, Adjei BN, Alhassan MM, Nakua EK
Objective To assess the prevalence, treatment outcomes and determinants of tuberculosis (TB)-HIV coinfection in Ghana. Study design A retrospective review of TB case register for Kwabre East Municipality was conducted for the period 2010-2020 to identify TB-HIV coinfections. Sett…
Zelnick JR, Seepamore B, Daftary A, Amico KR, Bhengu X, et al.
…cial workers may have a unique role to play in improving DR-TB-HIV outcomes. We designed, implemented and evaluated a model-based pilot training course on patient-centered care, treatment literacy in DR-TB and HIV coinfection, patient support group facilitation, and self-care. Te…
Hayibor KM, Bandoh DA, Asante-Poku A, Kenu E
…th challenge in Ghana as well as many developing countries. Treatment outcome monitoring is a vital part of the surveillance needed to successfully eliminate TB. The impact of HIV status and demographic and treatment-related factors on adverse TB treatment outcome has not been st…
Aung ZZ, Saw YM, Saw TN, Oo N, Aye HNN, et al.
…with the highest burden of tuberculosis and HIV infections (TB-HIV) in the world. However, the survival rate and risk factors for mortality among TB-HIV co-infected patients in the country remain unstudied. Therefore, the purpose of this study was to examine these factors. Method…
Naidoo K, Rampersad S, Karim SA
…key risk factor for the development of active TB infection. Treatment integration is a key in reducing mortality in patients with HIV-TB co-infection. However, this opportunity to improve outcomes of both infections is often missed or poorly implemented. Challenges in TB-HIV trea…
Maji D, Agarwal U, Kumar L, V V, Sharma A
…was to evaluate the clinical presentation and outcome of TB treatment in HIV-TB co-infected patients receiving daily anti-tubercular therapy (ATT) and concurrent antiretroviral therapy (ART) at a tertiary respiratory care centre in New Delhi, India. The research was cross-section…
Musaazi J, Sekaggya-Wiltshire C, Kiragga AN, Kalule I, Reynolds SJ, et al.
OBJECTIVE To examine tuberculosis (TB) treatment outcomes from a long-term TB-HIV (human immunodeficiency virus) integrated model of care at the Infectious Diseases Institute Clinic, Kampala, Uganda. METHODS We included HIV-positive adults who were new TB cases initiated on anti-…
Demitto FO, Schmaltz CAS, Sant'Anna FM, Arriaga MB, Andrade BB, et al.
…ns to treat both diseases concomitantly. Nevertheless, some TB-HIV patients undertaking ARVs (ARV-experienced) are already failing the first line efavirenz-based regimen and seem to display different response to second line ARV therapy and exhibit other predictors of mortality. M…
Akanbi K, Ajayi I, Fayemiwo S, Gidado S, Oladimeji A, et al.
…g countries. World Health Organization (WHO) recommends 85% treatment success rate for all TB cases as an indicator of TB control. The study aimed at determining TB treatment success rate among TB-HIV co-infected patients and identifying predictors of successful treatment among p…
Selimin DS, Ismail A, Ahmad N, Ismail R, Mohd Azman NF, et al.
…tudy aimed to identify the characteristics, unsuccessful TB treatment rate, and determinants of unsuccessful TB treatment outcome among patients with TB-HIV coinfection in Kuala Lumpur. Methods This was a cross-sectional study. The data of all patients with TB-HIV in the federal …
Maemun S, Mariana N, Rusli A, Mahkota R, Purnama TB
…ART) is essential to increase the survival of patients with TB-HIV coinfection. The aim of this study is to investigate the effect of ARV treatment initiation within TB treatment duration for the survival of patients with TB-HIV coinfection. Methods This is a retrospective cohort…
Nardotto GHB, Bollela VR, Rocha A, Della Pasqua O, Lanchote VL
…iving with HIV. This study aims to assess the effect of HIV coinfection and antiviral therapy on the plasma exposure to FLATDs in patients with TB. HIV negative (TB-HIV- group; n = 15) and HIV positive (TB-HIV+ group; n = 18) adult patients with TB were enrolled during the second…
Vonasek BJ, Rabie H, Hesseling AC, Garcia-Prats AJ
…ally. However, advances in children have lagged behind, and TB-HIV coinfection continues to be a major driver of pediatric mortality in many settings. This review highlights recent research findings in the areas of prevention, diagnosis, and treatment of HIV-associated childhood …
Tamene W, Abebe M, Wassie L, Mollalign H, Bauer K, et al.
… microbial products have not been well studied. Method HIV (TB-HIV+), TB (TB+HIV-) and TB/HIV co-infected (TB+HIV+) patients as well as apparently healthy controls (TB-HIV-) were recruited. TB and HIV patients were treatment naïve while TB/HIV patients were both ART naïve and exp…
Wyrsch F, von Braun A, Sekaggya-Wiltshire C, Haller S, Ledergerber B, et al.
…d TB drug levels were obtained at Week 0, 2, 8 and 24 of TB treatment. RESULTS: A total of 107 patients were included in this analysis. Random plasma glucose ≥200 mg/dL was found in 1/53 (2%) participant at Week 0. The prevalence of FPG ≥ 126 mg/dL decreased from 8/41 (20%) at We…
Gemechu LL, Debusho LK
…a; there is, however, no information on spatial patterns of TB-HIV coinfection in the country at the districts level at least using yearly data. This paper, therefore, aimed at determining the spatial clustering of TB-HIV coinfection prevalence rates in the country at the distric…
Enimil A, Antwi S, Yang H, Dompreh A, Alghamdi WA, et al.
…er than 3 years old (young children) with tuberculosis (TB) coinfection. To date, there are insufficient data to recommend nevirapine-based therapy during first-line antituberculosis (anti-TB) therapy in young children. We compared nevirapine pharmacokinetics (PK) in HIV-infected…
Adamu AL, Aliyu MH, Galadanci NA, Musa BM, Lawan UM, et al.
Background Successful tuberculosis (TB) treatment is essential to effective TB control. TB-HIV coinfection, social determinants and access to services influenced by rural residence can affect treatment outcome. We examined the separate and joint effects of rural residence and HIV…