Showing 1–25 of 121 documents
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Raj Narayan Yadav, Manpreet Bhalla, Yellanki Yashwanth Chowdary, Ajoy Kumar Verma, Gaurav Kaushik, et al.
**BACKGROUND:** Pediatric tuberculosis is an important subset of tuberculosis infection burden with a high detection gap due to paucibacillary nature. GeneXpert MTB/RIF assay detects rifampicin resistant (RR) Mycobacterium tuberculosis (MTB) that provides bacillary load and mutat…
Madzgharashvili T, Salindri AD, Magee MJ, Tukvadze N, Avaliani Z, et al.
Background Among pediatric patients with multidrug-resistant tuberculosis (MDR-TB), limited data exist regarding treatment outcomes in the context of the new and repurposed second-line TB drugs (SLDs). We aimed to describe the treatment outcomes among pediatric MDR-TB patients re…
Epperson K, Crane C, Ingulli E
Donor derived infections (DDIs) in pediatric kidney transplant recipients remain challenging to diagnose and can result in serious morbidity and mortality. This review summarizes the current guidelines and recommendations for prevention, diagnosis, and treatment of unexpected DDI…
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Harichander S, Wiafe E, Mensah KB, Bangalee V, Oosthuizen F
…te the incidence of TB and drug-resistant (DR) TB among the pediatric population. It also reviews the therapeutic options available to treat the condition. Methods A comprehensive search for all relevant evidence was conducted. The following databases were searched: MEDLINE, CINA…
Sun WW, Yang M, Chen XH, Fan LC, Wu HY, et al.
…ety of an all-oral bedaquiline (BDQ)-containing regimen for pediatric multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) through a multicenter, retrospective study in China. Methods In the study, pediatric patients receiving all-oral BDQ-containing regimen (BDQ group) with c…
Chiang SS, Sheremeta Y, Padilla RS, Jenkins HE, Horsburgh CR Jr, et al.
Few reports have described pediatric Multidrug-resistant Tuberculosis (MDR-TB) in the former Soviet republics, despite the fact that these countries have the highest proportion of TB cases that are MDR. We aimed to examine pediatric MDR-TB in Ukraine. This retrospective cohort st…
Dayal R, Agarwal D, Bhatia R, Bipin C, Yadav NK, et al.
… of latent tuberculosis (TB) infection and TB disease among pediatric household contacts of adult drug resistant (MDR) and drug susceptible (DS) TB patients and to identify the risk factors for occurrence of TB infection in the contacts. Methods Pediatric household contacts (less…
Jouego CG, Agbor VN, Noeske J, Manuel NA, Ayuk LN
…o difficulties in isolating Mycobacterium tuberculosis from pediatric specimens, management with toxic second line drugs, and practically the inexistence of contact tracing. In 2016, the World Health Organization (WHO) recommended a standardized 9-month regimen for adults and chi…
Kashyap B, Jhanjharia S, Saha R, Gomber S
Background Multi-drug resistance (MDR) in pediatric tuberculosis (TB) is a growing global threat. Unavailability of conventional or molecular drug susceptibility test (DST) in resource-limited settings often impede the determination of the extent of first line anti-tubercular dru…
Mustafa G, Almarshad F
… countries. This study focuses on the burden and pattern of pediatric and adolescent MDR-TB in a tertiary care hospital setting. Aims/objectives The main objective is to evaluate MDR-TB's prevalence and resistance patterns among pediatric and adolescent patients, highlighting cri…
Mane SS, Shrotriya P
…TB in children, which accounts for around 31% of the global pediatric TB load. However, over the past 10 y, children have consistently made up 6-7% of all patients treated yearly under the National Tuberculosis Elimination Programme (NTEP). There is an estimated detection gap of …
Misra S, Misra N, Seepamore B, Holloway K, Singh N, et al.
…mpacts their physical, mental, and social well-being. These pediatric patients and their families therefore develop strategies for coping with these disruptions to their lives. In general, there were major disruptive experiences that resulted from the process around receiving a d…
Warnken Z, Trementozzi A, Martins PP, Parekh J, Koleng JJ, et al.
…vidable oral dosage form has limited the use of the drug in pediatric populations, who may require lowering of the dose to reduce the likelihood of adverse drug events. In this study, pediatric-friendly CFZ mini-tablets were prepared from micronized powder via direct compression.…
Torane VP, Nataraj G, Kanade S, Deshmukh CT
…objective Global TB report 2021 mentions 11 % prevalence of pediatric TB, whereas 5.65% of the cases were reported from India in 2020. India features in the list of TB high burden countries, HIV-TB high burden and MDR-TB high burden countries. The diagnosis of pulmonary tuberculo…
Sekarsari D, Handoyono QF, Amal MY, Maharani MAP, Hendriarto A
… of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, …
Jhanjhria S, Kashyap B, Gomber S, Gupta N, Hyanki P, et al.
…tations in Mycobacterium tuberculosis strains isolated from pediatric TB patients from a tertiary care hospital. Material and methods A total of 51 pulmonary and extra pulmonary specimens were collected from clinically suspected pediatric TB cases, who were microbiologically conf…
Jungrungrueng T, Anugulruengkitt S, Lauhasurayotin S, Chiengthong K, Poparn H, et al.
…terial infection, and clinical impact of these organisms on pediatric oncology patients with febrile neutropenia. Methods A retrospective descriptive study of oncologic patients aged less than 15 years who were diagnosed with febrile neutropenia in King Chulalongkorn Memorial Hos…
Gupta S, Khanna H, Gupta V, Barman NK, Parihar A, et al.
Objective To identify chest X-ray (CXR) characteristic of Pediatric pulmonary drug-resistant tuberculosis (DRTB) in comparison to drug sensitive tuberculosis (DSTB) for early identification and treatment of DRTB. Methods This was a prospective cross-sectional study in which CXR p…
Park M, Owles H, Williams A, Williams B, Whittaker E, et al.
…ildhood death and morbidity worldwide. The diagnosis in the pediatric population remains challenging due to the paucibacillary nature of the disease. Intrathoracic lymphadenopathy is one of the most common manifestations of primary disease but is often difficult to sample. A retr…
Schäfer HL, Barker M, Follmann P, Günther A, Hörning A, et al.
…longs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case-control study to analyze MDR-pTB cases in Germany between 2010 and 2020 in comparison to a drug-susceptible (DS)-pTB group. We included…
Iqbal A, Ashraf M, Rathore AW, Omer MO, Anjum AA, et al.
…cobacterium tuberculosis (MDR-MTB) isolates, collected from pediatric patients. Fractions of Aloe vera and Allium sativum extracts were separated using glass column chromatography, followed by evaluation of cytotoxicity and mutagenicity by tetrazolium salt (3-(4,5-dimethylthiazol…
K S S, Saldanha PRM, Kushwah S, Prabhu AS
…ntrol. Objectives To know the current practices among local pediatricians regarding management of TB. Materials and methods Field based cross sectional study. All the registered pediatricians who were practicing in Mangalore, (list - local IAP branch) were included in the study. …
Taneja R, Nahata MC, Scarim J, Pande PG, Scarim A, et al.
…temperature or 30°C for several weeks, to support pragmatic pediatric dosing in the field and reduce wastage. METHODS: BDQ tablets were suspended in simple syrup and a sugar-free vehicle. Each 20 mg/mL formulation was stored at room temperature or 30°C for 30 days in amber dispen…
Yeshiwork Abebaw, Arash Ghodousi, Dawit Hailu Alemayehu, Abaysew Ayele, Gebremedhin Gebremicael, et al.
…curring with multidrug-resistant tuberculosis (MDR-TB) in a pediatric patient. **CASE PRESENTATION:** A 12-year-old HIV-negative female with a previous history of tuberculosis was admitted in August 2021 to Selale University Comprehensive Specialized Hospital in Ethiopia. She wa…