Showing 1–25 of 141 documents
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Pei-Yao Zhai, Xiao Zang, Ting Jiang, Jian Feng, Bin Zhang, et al.
**BACKGROUND:** China faces high burden of multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB). We aimed to evaluate the impacts of Vaccae vaccination and enhanced drug-resistant TB (DR-TB) management strategies. **METHODS:** Using a compartmental model calibrat…
Keogh-Brown MR, Sumner T, Sweeney S, Vassall A, Jensen HT
Background Tuberculosis (TB) imposes a substantial health and economic burden on many populations and countries, but lack of funding has significantly contributed to several countries falling short of global TB reduction targets. Furthermore, existing assessments of the economic …
Ramachandran R, Dumitrescu A, Baiceanu D, Popa C, Dragomir A, et al.
Background Tuberculosis (TB) remains a global health challenge, with 1.3 million deaths in 2022. Ten countries in the European Union (EU) and European Economic Area (EEA) accounted for 88.3% of TB cases, of which 23.8% were from Romania. Evidence shows that mental health issues, …
Danyuchen Sun, Zhili Li, Yingpeng Qiu, Wei Shu, Lijie Zhang, et al.
…ulosis drugs approved in China and recommended by the World Health Organization, with demonstrated good efficacy and safety profile in clinical trials. However, health economic evaluations of these new drugs using modeling approaches are limited in China. This study aims to evalu…
Mpagama SG, Ezekiel MJ, Mbelele PM, Mbelele PM, Chongolo AM, et al.
…DR-TB that led to seeking services outside the conventional health system; 2) Socio-economic adversity made health-seeking behavior difficult and often unproductive; 3) In the health system, challenges included inadequacy of MDR-TB diagnostic centers, lack of knowledge on behalf …
Van Rie A, De Vos E, Costa E, Verboven L, Ndebele F, et al.
…-resistant tuberculosis (RR-TB) remains an important global health problem. Ideally, the complete drug-resistance profile guides individualized treatment for all RR-TB patients, but this is only practised in high-income countries. Implementation of whole genome sequencing (WGS) t…
Chandra A, Kumar R, Kant S, Parthasarathy R, Krishnan A
…earch terms were "tuberculosis" AND "costs" (cost Analysis, economics, cost of illness, health care costs, health expenditures, direct service costs, catastrophic cost) AND "India". The cost of TB care was from the patient's perspective. Data regarding costs were extracted, index…
Alene KA, Clements ACA, McBryde ES, Jaramillo E, Lonnroth K, et al.
…l, social and economic sequelae of MDR-TB and to assess the health-related quality of life in patients with MDR-TB. Methods and analysis We will perform a systematic review and meta-analysis of published studies reporting sequelae of MDR-TB. We will search PubMed, SCOPUS, ProQues…
Cheng Q, Dang T, Nguyen TA, Velen K, Nguyen VN, et al.
…ART) trial is a randomised controlled trial of using mobile health (mHealth) technologies to improve adherence to medications and management of adverse events (AEs) in people with multidrug-resistant tuberculosis (MDR-TB) undergoing treatment in Vietnam. This economic evaluation …
Gauri Dhumal, Neetal Nevrekar, Nikhil Gupte, Rechel Shrisunder, Prashant Kulkarni, et al.
…rceived and experienced stigma, and socio-economic burdens. Health system-related challenges encompassed delayed diagnosis, drug stockouts, and negative experiences with Health Care Providers (HCPs). Among 75 participants, the median age was 20.5 years, with 57% (n = 41) females,…
Fekadu G, Yao J, You JHS
…rden countries. Expert opinion : The paucity of model-based health economic analyses on BDQ-containing regimens for DR-TB indicated that further pharmacoeconomic research of BDQ-based regimens, on the aspects of duration of BDQ treatment, types of DR-TB indicated, and settings of…
Park HY, Kwon JW, Kim HL, Kwon SH, Nam JH, et al.
… group) to treat newly diagnosed MDR-TB patients. Methods A health economic analysis over lifetime horizon (20 years) from the perspective of the healthcare system in Korea was conducted. We developed a combined simulation model of a decision tree model (initial two years) and tw…
Patel LN, Gurumurthy M, Bronson G, Sanders K, Rusen ID
…, community engagement, regulatory and ethics requirements, health economics, and other (respondent designated) about which a practical guide would be useful to improve future trial implementation. For each aspect of trial implementation selected, respondents were asked to report…
Chatterjee S, Das P, Vassall A
…to curb the spread of coronavirus infection had significant health and economic impacts on the Indian economy. There is limited empirical evidence on how COVID-19 restrictive measures may impact the economic welfare of specific groups of patients, e.g., tuberculosis patients. We …
Lange C, Aarnoutse RE, Alffenaar JWC, Bothamley G, Brinkmann F, et al.
…mpicin and isoniazid) represents a growing threat to public health and economic growth. Never before in the history of mankind have more patients been affected by MDR-TB than is the case today. The World Health Organization reports that MDR-TB outcomes are poor despite staggering…
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, et al.
…l pathogen worldwide, represents a growing threat to public health and economic growth. The global burden of multidrug-resistant tuberculosis (MDR-TB) has recently increased by an annual rate of more than 20%. According to the World Health Organization approximately only half of …
Peresu E, De Graeve D, Heunis JC, Kigozi NG
…ed therapy (DOT) and MDR-TB injection administration to lay health workers, to a routine clinic-based strategy within an established national TB programme in Eswatini. Methods Data on costs and effects of the two ambulatory models of MDR-TB care was collected using documentary da…
Song WM, Li YF, Ma XB, Liu JY, Tao NN, et al.
…stant tuberculosis (DR-TB) has contributed to a significant health and economic burden on a global scale, especially in China. we sought to estimate epidemiological characteristics of primary DR-TB in China from 2004 to 2018. Methods Eleven thousand four hundred sixty-seven newly…
Jingjing Li, Huxiao Sun, Dzmitry Shcharbin, Serge Mignani, Jean-Pierre Majoral, et al.
…disease caused by(), which puts enormous pressure on public health and economic systems worldwide. Therefore, accurate diagnosis and timely intervention of TB are critical for interrupting disease transmission and reducing mortality among TB patients. However, the low bioavailabi…
Du L, Zhang Y, Lv X, Duan Y, Shi X, et al.
…rug-resistant tuberculosis (MDR-TB) is the cause of serious health and economic burdens worldwide. The present study aimed to explore the initial and acquired drug-resistance rates among TB patients from 2012 to 2019 in Dalian, China. The effectiveness of MDR-TB prevention and co…
Smith I, Forse R, Sidney Annerstedt K, Thanh NT, Nguyen L, et al.
Introduction The health and economic burden of tuberculosis (TB) in urban Viet Nam is high. Social protection and support interventions can improve treatment outcomes and reduce costs. However, evidence regarding optimal strategies in this context is lacking. This study aimed to …
Zhongfei Pei, Sok King Ong, Siyan Yi, Chitin Hon, Ming Xu
…access to anti-tuberculosis drugs remains a pressing global health challenge. We aim to investigate consumption trends across nine Asia-Pacific countries between 2019 and 2022. **METHODS:** We used pharmaceutical sales data from three databases to analyze 17 anti-tuberculosis dr…
Nida Khan, Muhammad Ahmar Khan, Naila Muzaffar, Ahmad Ismail, Abdul Ghafoor, et al.
…iotics with reduced treatment duration are available. World Health Organization guidelines recommend the use of shorter all-oral regimens under operational research. To guide recommendations, we will compare two all-oral, short (≤ 11 months) regimens for the outcome…
Bao J, Sha W, Zhang WH, Zhang T, Muldoon K, et al.
…a has been playing an increasingly important role in global health in recent decades. Substantial progress and reform has been made in the country's health care system, but China still hosts one third of the world's diabetes mellitus (DM) patients and one fifth of the world's tub…
Allué-Guardia A, Saranathan R, Chan J, Torrelles JB
…sistant strains of Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses the need to develop new therapeutic strategies. The notion of phage therapy against bacteria has been around for more than a century and, although its implementation was …