Showing 176–200 of 200 documents
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Kumar L, Kumar S, Vohra V, Mohan K, Khayyam KU
…factors influence adherence to the lengthy duration of anti-tuberculosis treatment, making it a complicated and dynamic problem. The objective of this study was to investigate the treatment interruption patterns using pre-defined criteria among a cohort of pulmonary tuberculosis …
Abdul JBPAA, Adegbite BR, Ndanga MED, Edoa JR, Mevyann RC, et al.
…DR-TB control strategies. Incidence of rifampicin-resistant tuberculosis (RR-TB) is a key indicator for monitoring MDR-TB. Methods In a longitudinal nationwide retrospective study, 8 years (2014-2021) of sputum samples from presumptively drug-resistant tuberculosis patients from …
Chen ML, Doddi A, Royer J, Freschi L, Schito M, et al.
…nosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susc…
Rashid F, Iqbal S, Tahseen S, Zhao Y
…mmended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes. However, resistance against this drug has increased, resulting in serious co…
Martín-García M, Esteban J
Introduction : Despite efforts to the contrary, tuberculosis remains one of the leading causes of death in the world. The appearance of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis has increased the need for new therapeutic …
Gong Z, Wang G, Zeng J, Stojkoska A, Huang H, et al.
…processes in both eukaryotes and prokaryotes. Mycobacterium tuberculosis ( M. tuberculosis ), the causative agent of tuberculosis, remains one of the most formidable threats worldwide. Although DNA methylation of M. tuberculosis has been documented, little information is availabl…
Bi K, Cao D, Ding C, Lu S, Lu H, et al.
Tuberculosis (TB) is an ancient infectious disease. Before the availability of effective drug therapy, it had high morbidity and mortality. In the past 100 years, the discovery of revolutionary anti-TB drugs such as streptomycin, isoniazid, pyrazinamide, ethambutol and rifampicin…
Getu Diriba, Ayinalem Alemu, Bazezew Yenew, Betselot Zerihun Ayano, Michael Hailu, et al.
…BJECTIVES:** To estimate the proportion of second-line anti-tuberculosis drug resistance among multidrug-resistant tuberculosis (MDR-TB) patients in Ethiopia. **METHODOLOGY:** A laboratory-based prospective cross-sectional study was conducted at the National Tuberculosis Referen…
Shevchenko OS, Todoriko LD, Pohorelova OO, Semianiv IO, Ovcharenko IA, et al.
…no acids in pathogenetic therapy in patients with pulmonary tuberculosis on liver function. Patients and methods Materials and methods: The study included 50 patients with drug susceptible TB and 50 patients with drug-resistant TB (multidrug-resistant and extensively drug-resista…
Fadzil FA, Ramli SR, Neoh H
In Malaysia, tuberculosis remains a public health problem despite initiatives in disease control and prevention. This review explores the timeline of pulmonary tuberculosis (PTB) in Malaysia, epidemiology, management and outlook of the disease in the country. PTB was first report…
Nagdev PK, Agnivesh PK, Roy A, Sau S, Kalia NP
Tuberculosis, caused by Mycobacterium tuberculosis, is a fatal infectious disease that prevails to be the second leading cause of death from a single infectious agent despite the availability of multiple drugs for treatment. The current treatment regimen involves the combination …
Ahmad A, Akhtar J, Ahmad M, Khan MI, Wasim R, et al.
…th Organization reports 500,000 new cases of drug-resistant tuberculosis (TB), which poses a serious global danger. The increased number of XDR-TB and MDR-TB cases reported worldwide necessitates the use of new therapeutic approaches. The main issues with the antitubercular medic…
Zong Z, Jing W, Shi J, Wen S, Zhang T, et al.
…efficacious in treating mycobacterial infections, including tuberculosis (TB) caused by drug-resistant Mycobacterium tuberculosis In this study, we compared the in vitro activities and MIC distributions of delpazolid, a novel oxazolidinone, and linezolid against multidrug-resista…
Hasan Z, Razzak SA, Kanji A, Shakoor S, Hasan R
…oduction Single-nucleotide variants (SNVs) in Mycobacterium tuberculosis (M. tuberculosis) genomes can predict multidrug resistance (MDR) but not all phenotype-genotype correlations can be explained. We investigated SNVs in efflux pumps (EPs) in the context of M. tuberculosis dru…
Yingying Yuan, Pengxiang Li, Xiangjie Qiu, Honghua Zhang, Hao Chen, et al.
**OBJECTIVES:** Clinical data on bone and joint tuberculosis (BJTB) in developing countries remain limited. This study aims to investigate the clinical, epidemiological, and drug-resistance characteristics of BJTB patients in Central China and to optimize diagnostic strategies. …
Anjali Saxena, Summer Bhagra, Shuvayoo Das, Naveen Kaushik, Biswajit Saha
…drug-resistant and extensively drug-resistant strains of M. tuberculosis. The escalating prevalence of multidrug-resistant and extensively drug-resistant strains, compounded by the pathogen's extraordinary capacity to survive within host macrophages and pharmacologically impenetr…
Zhao LL, Li MC, Liu HC, Xiao TY, Li GL, et al.
Mycobacterium tuberculosis Beijing genotype strains are widespread globally. However, there has been no systematic study on the association between Beijing genotype and the characteristics of drug resistance. In this study, 359 M. tuberculosis isolates from south China were colle…
Xu Y, Liu F, Chen S, Wu J, Hu Y, et al.
Background In the current scenario, the drug-resistant tuberculosis is a significant challenge in the control of tuberculosis worldwide. In order to investigate the in vivo evolution of drug-resistant M. tuberculosis, the present study envisaged sequencing of the draft genomes of…
Fan Jiang, Xuemei Li, Qing Qiao, Mingming Zhang, Yuan Tian, et al.
**BACKGROUND:** Tuberculosis (TB) persists as a leading global health threat. Current surveillance is fragmented, and the surgical burden of drug-resistant forms remains poorly quantified. **METHODS:** Using GBD 2021 (1990-2050) and WHO-GHO (2000-2021), we estimated mortality, i…
Guo Y, Li J, Lin L
Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis . Drug-resistant tuberculosis (DRTB) includes multidrug-resistant tuberculosis without extensive drug resistance (MDRTB) and extensively drug-resistant tuberculosis (EDRTB). Recently, with …
Fouda M, Mantargi MJS, Germoush MO, Sarhan M, Husein MF, et al.
Background Mycobacterium tuberculosis (Mtb), a pathogen that belongs to the M. tuberculosis complex, causes tuberculosis (TB), an infectious bacterial disease. Although it usually affects the lungs and results in pulmonary TB, it can also lead to extra-pulmonary TB by affecting o…
Brust JCM, Gandhi NR, Wasserman S, Maartens G, Omar SV, et al.
…treatment outcomes in patients with rifampin-resistant (RR) tuberculosis but prolongs the QT interval and carries a black-box warning from the US Food and Drug Administration. The World Health Organization recommends that all patients with RR tuberculosis receive a regimen contai…
Santos NCS, Scodro RBL, de Almeida AL, Baldin VP, Nakamura de Vasconcelos SS, et al.
…e of multidrug and extensively drug resistant Mycobacterium tuberculosis strains turns the search for new tuberculosis (TB) treatment options of paramount importance. Objective In this sense, the present study evaluates the in vitro activity of isoniazid (INH)/rifampicin (RIF)/le…
Malík I, Čižmárik J, Pecháčová M
The prevalence of multidrug-resistant tuberculosis (MDR--TB) and extensively drug-resistant tuberculosis (XDR--TB) has been increasing at an alarming rate worldwide. Todays “Fight against Tuberculosis“ programmes in the Russian Federation are subsidized by state and r…
Ji L, Tao FX, Yu YF, Liu JH, Yu FH, et al.
Objective The burden of both general and drug-resistant tuberculosis in rural areas is higher than that in urban areas in China. To characterize the genetic structure and transmission risk of Mycobacterium tuberculosis in rural China, we used whole genome sequencing to analyze cl…