Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Cen Y, Li J, Wang G, Li S, Xiang W, et al.
Cranial tuberculosis is a relatively infrequent inflammatory reaction caused by tuberculous bacilli invading the skull. Most cases of cranial tuberculosis are secondary to tuberculosis foci in other parts of the body; primary cranial tuberculosis is extremely rare. Herein, we rep…
Zhang D, Hao J, Hou R, Yu Y, Hu B, et al.
What is known and objective Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most significant adverse reactions for this line of therapy. N-acetyltransferase 2 (NAT2) is an important metabolic enzyme involved in drug metabolism and detoxification. Genetic polymorp…
Wang L, Wen Z, Ma H, Wu L, Chen H, et al.
Accurate diagnosis of complete inactivation of tuberculosis lesions is still a challenge with respect to sputum-negative tuberculosis. RNA-sequencing was conducted to uncover potential lncRNA indicators of metabolic activity in tuberculosis lesions. Lung tissues with high metabol…
Zhou Y, Wang F, Huang L, Liu K, Zhang Y, et al.
…ucted a retrospective study to investigate risk factors for tuberculosis care-seeking delay and diagnostic delays among pediatric pulmonary tuberculosis cases in Zhejiang Province from 2013 to 2022. Among 1274 cases, 49.61% experienced tuberculosis care-seeking delays (> 14 days …
Ayoun Alsoud R, Svensson RJ, Svensson EM, Gillespie SH, Boeree MJ, et al.
…e characteristics of biological processes. In Mycobacterium tuberculosis , common biomarkers used in clinical drug development are colony forming unit (CFU) and time-to-positivity (TTP) from sputum samples. This analysis aimed to develop a combined quantitative tuberculosis bioma…
James M Day
Intestinal tuberculosis is an uncommon but clinically significant manifestation of tuberculosis that often presents with nonspecific gastrointestinal symptoms. Although the ileocecal region is most frequently involved, overt gastrointestinal bleeding is an unusual presentation, p…
Matteelli A, Churchyard G, Cirillo D, den Boon S, Falzon D, et al.
The provision of tuberculosis preventive treatment is one of the critical interventions to reduce tuberculosis incidence and ultimately eliminate the disease, yet we still miss appropriate tools for an impactful intervention and treatment coverage remains low. We used recent data…
Kumar R, Kant S, Chandra A, Krishnan A
…use and nicotine dependence among newly diagnosed pulmonary tuberculosis patients to help inform effective implementation of tobacco cessation strategies among tuberculosis patients to improve treatment outcomes. Materials and methods This was a cross-sectional study conducted am…
Weiwei Lin, Xinchun Zhou, Shiyu Fang, Fengjun Liu, Jie Sun
… aim of this study was to investigate the expression of the tuberculosis-specific antigen, CFP10, in renal tuberculosis lesion tissues through immunohistochemical (IHC) staining and to assess its potential value in the pathological diagnosis of renal tuberculosis. **METHODS:** A…
D Lamireou, B N Ngandolo, P Koné, S Tadio, C Diguimbaye, et al.
**BACKGROUND:** Tuberculosis is a zoonotic disease affecting domestic ruminants, human worldwide and caused bythat belongs to. In Chad, tuberculosis caused bywas previously isolated from both suspected patients and domestic ruminant carcass. **OBJECTIVES:** The objective of our …
Abudurexiti T, Haibier A, Yusufu A, Shoukeer K, Lin H
…s to investigate the clinical efficacy of endoscopic spinal tuberculosis focus removal, posterior pedicle lesion removal, bone grafting, and internal fixation combined with drug chemotherapy in treating thoracolumbar tuberculosis. It also seeks to summarize strategies for prevent…
Bhengu KN, Singh R, Naidoo P, Mpaka-Mbatha MN, Nembe-Mafa N, et al.
Background Helminth infections are widespread in tuberculosis-endemic areas and are associated with an increased risk of active tuberculosis. In contrast to the pro-inflammatory Th1 responses elicited by Mycobacterium tuberculosis (Mtb) infection, helminth infections induce anti-…
Demissie TA, Belayneh D
Background Mycobacterium Tuberculosis (MTB) and its drug resistance form are the devastating infectious diseases in the world. It is the major cause of morbidity and mortality in low-income countries with Ethiopia carrying a heavy burden. Data on the magnitude of MTB and rifampic…
The “WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis – Tests for tuberculosis infection” is a new consolidated policy guideline on tests for TB infection. The policy includes, for the first-time recommendations on a new class of Mycobacterium tuberculosis antigen…
Prince Agyeman, Nixon Ntiri Somuah, Yussif Adams, Felix Abekah Botchway
**BACKGROUND:** Tuberculosis (TB) remains a significant public health problem in Ghana, with high morbidity and mortality rates. Persons with TB are at risk of adverse cardiovascular disease with hyperlipidemia being a major risk factor. The standard treatment for pulmonary TB in…
Lou H, Zhang F, Lu L, Ding Y, Hao X
Anti-tuberculosis drug induced hepatotoxicity is the main problem in tuberculosis patients. Xanthohumol, a major prenyl chalcone present in hops, has diverse biological activities including antibacterial and hepatoprotective activities. The present research aimed to investigate t…
Prendergast KA, Nagalingam G, West NP, Triccas JA
New control measures are urgently required to control tuberculosis (TB), as the current vaccine, Bacille Calmette-Guérin (BCG), has had a limited impact on disease spread. The identification of virulence mechanisms of Mycobacterium tuberculosis is an important strategy in vaccine…
Bespyatykh J, Shitikov E, Bespiatykh D, Guliaev A, Klimina K, et al.
Tuberculosis, caused by Mycobacterium tuberculosis complex bacteria, remains one of the most pressing health problems. Despite the general trend towards reduction of the disease incidence rate, the situation remains extremely tense due to the distribution of the resistant forms. …
Gao M, Cheng L, Wang Q, Yang Q, Wang X, et al.
…ristics, diagnosis and prognosis of patients with laryngeal tuberculosis (LTB) combined with respiratory tuberculosis. Materials and methods A retrospective analysis was conducted on 134 patients who underwent endoscopy and were eventually diagnosed with LTB. The patients' demogr…
Han X, Li T, Fan Y, Wang X, Gu W, et al.
Background Mycobacterium tuberculosis (MTB) sRNAs are abundant. However, the level of MTB sRNA in peripheral blood remains elusive. Methods Twenty MTB sRNAs annotated in the reference genome of H37Rv were detected in the plasma of 170 active pulmonary tuberculosis patients and 12…
Ashhurst AS, Parumasivam T, Chan JGY, Lin LCW, Flórido M, et al.
Tuberculosis places a staggering burden on human health globally. The new World Health Organisation End-TB Strategy has highlighted the urgent need for more effective TB vaccines to improve control of the disease. Protein-based subunit vaccines offer potential as safe and effecti…
Zein-Eddine R, Hak F, Le Meur A, Genestet C, Dumitrescu O, et al.
The date of Mycobacterium tuberculosis complex emergence has been the subject of long debates. New studies joining archaeological efforts with sequencing methods raise high hopes for solving whether this emergence is closer to 70,000 or to 6000 years before present. Inferring the…
Kim S, Hesseling AC, Wu X, Hughes MD, Shah NS, et al.
…derstanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting contact investigations. Methods Using data from a cros…
van Alen I, Aguirre García MA, Maaskant JJ, Kuijl CP, Bitter W, et al.
The β-lactamase of Mycobacterium tuberculosis, BlaC, hydrolyzes β-lactam antibiotics, hindering the use of these antibiotics for the treatment of tuberculosis. Inhibitors, such as avibactam, can reversibly inhibit the enzyme, allowing for the development of combination therapies …
Sousa J, Cá B, Maceiras AR, Simões-Costa L, Fonseca KL, et al.
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show t…