Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Harikishore A, Mathiyazakan V, Pethe K, Grüber G
Introduction Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the most devastating bacterial disease. Multidrug-resistant Mtb strains are spreading worldwide, underscoring the need for new anti-TB targets and inhibitors. The respiratory chain complexes, including…
Pietersen E, Anderson K, Cox H, Dheda K, Bian A, et al.
…HO) treatment guidelines prioritize all-oral drug-resistant tuberculosis (DR-TB) regimens. Several poorly tolerated drugs, such as amikacin and para-aminosalicylic acid (PAS), remain treatment options for DR-TB in WHO-recommended longer regimens as Group C drugs. Incomplete treat…
Sun L, Zhang L, Wang T, Jiao W, Li Q, et al.
…ed with the development of drug resistance in Mycobacterium tuberculosis (MTB). However, the mechanisms underlying drug resistance at the molecular level remain partly unclear. Therefore, the purpose of this study was to investigate the potential functional effect of novel mutati…
Shuaib YA, Khalil EAG, Wieler LH, Schaible UE, Bakheit MA, et al.
Pathogen-based factors associated with tuberculosis (TB) in eastern Sudan are not well defined. We investigated genetic diversity, drug resistance, and possible transmission clusters of Mycobacterium tuberculosis complex (MTBC) strains by using a genomic epidemiology approach. We…
Li Y, Dong W, Lan T, Fan J, Qin S, et al.
…inst the multidrug-resistant (MDR) strains of Mycobacterium tuberculosis Little is known about the distribution of linezolid in tuberculosis (TB) lesions in patients with MDR-TB. The aim of this study was to evaluate the distribution of linezolid in TB lesions in patients with sp…
Welekidan LN, Skjerve E, Dejene TA, Gebremichael MW, Brynildsrud O, et al.
Objectives Tuberculosis (TB) is a preventable and treatable infectious disease, but the continuing emergence and spread of multidrug-resistant TB is threatening global TB control efforts. This study aimed to describe the frequency and patterns of drug resistance-conferring mutati…
Mikiashvili L, Kempker RR, Chakhaia TS, Bablishvili N, Avaliani Z, et al.
…nical outcomes of persons retreated with new/companion anti-tuberculosis (TB) drugs for multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB). We sought to evaluate the efficacy and safety of bedaquiline and delamanid containing regimens among patients with and without pri…
Stephen S, Kadye A, Majuru XN, Madamombe T, Sokwe J, et al.
… the 30 high multidrug-resistant (MDR)/rifampicin-resistant tuberculosis (TB) burden. Rapid detection of rifampicin (RIF) and isoniazid (INH) is essential for the diagnosis of MDR-TB. The World Health Organization has recommended the use of molecular WHO-recommended rapid diagnos…
Kadia BM, Aroke D, Njefi KP, Tochie JN, Tianyi FL, et al.
Background Programs that integrate tuberculosis (TB) and human immunodeficiency virus (HIV) treatment aim to provide efficient treatment services and maximize successful treatment outcomes through the delivery of both TB and HIV treatment by one provider at the same time and loca…
Mahmood N, Bhatti S, Abbas SN, Shahid S, Shahid S, et al.
… and codon 85 in the pncA gene in local multidrug-resistant tuberculosis (MDR-TB) patients by developing a simple molecular test so that disease could be detected timely in the local population. DNA extracted from sputum-cultured samples from MDR-TB patients and subjected to semi…
Kumwenda GP, Chipungu G, Sloan DJ, Kaimila Y, Chiumya K, et al.
Background The emergence and spread of drug-resistant Tuberculosis (TB) is a major public health threat. TB resistance originates in the course of treatment due to genomic mutations in Mycobacterium tuberculosis (MTB). An increase in new cases with drug-resistant TB could be an i…
Ugwu KO, Onah IS, Mbah GC, Ezeonu IM
Introduction Tuberculosis (TB) continues to be a public health problem globally. The burden is further exacerbated in developing countries like Nigeria, by poor diagnosis, management and treatment, as well as rapid emergence of drug-resistant TB. This study was conducted to evalu…
Mwaba P, Chakaya JM, Petersen E, Wejse C, Zumla A, et al.
An estimated 1.8 billion people worldwide have a latent tuberculosis infection (LTBI), with wide variations in LTBI rates across countries. LTBI can be due to infection with either drug-sensitive or drug-resistant Mycobacterium tuberculosis (Mtb) strains. Accurate data on the pre…
Admassu F, Abera E, Gizachew A, Sedoro T, Gari T
…ective To identify the risk factors for multidrug resistant tuberculosis (MDR-TB) among patients with TB at selected MDR-TB treatment initiative centres, southern Ethiopia, 2021. Design An unmatched case-control study was employed. Setting Multidrug resistance treatment initiativ…
Singh PK, Singh U, Jain A
…yr A/B mutations in multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains and also to assess the association between different gyr A/B mutations with phenotypic resistance to moxifloxacin (MOX) at clinical breakpoint (CB) drug concentration. Method: A total of 106 cl…
Cheng Q, Xie L, Wang L, Lu M, Li Q, et al.
…ing and estimating the risk of incident multidrug-resistant tuberculosis (MDR-TB) among individuals with a previous tuberculosis history (PTBH). The purpose of this study was to assess the incidence of and risk factors for MDR-TB in those individuals. Methods: Between 2005 and 20…
Mansoori N, Pahlavanzadeh B, Atarjalali M
Background The emergence of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant (RR) TB poses a significant challenge for TB control initiatives on a global scale. This study's aim was to estimate the incidence of MDR-/RR-TB and identify the risk factors associated …
Puyén ZM, Santos-Lázaro D, Vigo AN, Cotrina VV, Ruiz-Nizama N, et al.
…ncing (WGS) is a promising tool in the global fight against tuberculosis (TB). The aim of this study was to evaluate the use of WGS in routine conditions for detection of drug resistance markers and transmission clusters in a multidrug-resistant TB hot-spot area in Peru. For this…
Cheng Q, Zhao G, Wang X, Wang L, Lu M, et al.
…and personalized prediction of incident multidrug-resistant tuberculosis (MDR-TB) after completing pulmonary tuberculosis treatment (CPTBT). A matched case-control study (1:2 ratios) was performed between 2005 and 2018. A multivariable Cox regression analysis was used to evaluate…
Jorwal P, Singh BK, Anand A, Khan F, Khandelwal K, et al.
Background Tuberculosis (TB) is caused due to the infection of Mycobacterium tuberculosis (MTB) and it can infect the various parts of the human body. The disease is highly prevalent and is the second most common cause of death worldwide after COVID-19. Apart from sputum specimen…
Pallas SW, Courey M, Hy C, Killam WP, Warren D, et al.
…een shown to be effective and cost-effective for diagnosing tuberculosis (TB) under conditions with high HIV prevalence and HIV-TB co-infection but less is known about Xpert's cost in low HIV prevalence settings. Cambodia, a country with low HIV prevalence (0.7%), high TB burden,…
Yuanyuan Yu, Jie Cao, Hongqiu Pan, Hui Zhong, Xiaocui Wu, et al.
…ne (BDQ) has gradually become a core drug in drug-resistant tuberculosis (DR-TB) treatment, and the additional benefits of prolonging BDQ use remain unclear. Patients with DR-TB who received a BDQ-containing regimen from three Chinese clinical centers between 1 March 2018 and 31 …
Shah M, Paradis S, Betz J, Beylis N, Bharadwaj R, et al.
Background Tuberculosis (TB) control is hindered by absence of rapid tests to identify Mycobacterium tuberculosis (MTB) and detect isoniazid (INH) and rifampin (RIF) resistance. We evaluated the accuracy of the BD MAX multidrug-resistant (MDR)-TB assay (BD MAX) in South Africa, U…
Pradipta IS, Idrus LR, Probandari A, Lestari BW, Diantini A, et al.
Background Previously treated tuberculosis (TB) patients are a widely reported risk factor for multidrug-resistant tuberculosis. Identifying patients' problems during treatment is necessary to control TB, especially in a high-burden setting. We therefore explored barriers to succ…
Salvato RS, Schiefelbein S, Barcellos RB, Praetzel BM, Anusca IS, et al.
Tuberculosis (TB) is the leading cause of death among infectious diseases worldwide. Among the estimated cases of drug-resistant TB, approximately 60% occur in the BRICS countries (Brazil, Russia, India, China and South Africa). Among Brazilian states, primary and acquired multid…