Showing 176–200 of 200 documents
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Ria Winkelmann, Belana Blasczok, Melanie Winter, Peter Wild, Maria J G T Vehreschild, et al.
**INTRODUCTION:** Extrapulmonary tuberculosis (TB) and non-tuberculous mycobacterial (NTM) disease remain a diagnostic challenge and conventional methods such as mycobacterial culture or molecular methods (e.g. GeneXpert) performed on formalin-fixed paraffin embedded (FFPE) speci…
Derong Kong, Zhenzhen Xu, Chang Chen, Yunqi Liu, Dacheng Wei
…(POC) testing holds great promise for transforming clinical diagnostics by enabling rapid, convenient, and accurate analysis outside of centralized laboratories. Among various emerging technologies, biological field-effect transistors (bio-FETs), which directly convert molecular …
Kiartipong Virapongsiri, Dararat Eksombatchai, Monruadee Chatreewarote, Viboon Boonsarngsuk
**BACKGROUND:** Data on tuberculosis-polymerase chain reaction (TB-PCR) diagnostic yield in induced sputum (IS) samples is limited. This study was conducted to evaluate the diagnostic yield of TB-PCR in IS samples from patients with pulmonary TB and to identify factors that are a…
Ayanleye Ahmed Abdulakeem, Oloyede Oyegbade Olanrewaju, Olurotimi Ogundokun Akinjide, Fehintola Awopeju Olayemi, Sebutu Bello Ibrahim, et al.
**BACKGROUND:** Despite the availability of directly observed treatment short-course, which provides free treatment to patients with tuberculosis, leading to some progress, Nigeria still faces a slow decline in tuberculosis incidence and low case detection. The delay in diagnosis…
Li B, Sun L, Sun Y, Zhen L, Qi Q, et al.
Background Tuberculosis (TB) is an infectious disease with high mortality, and mining key genes for TB diagnosis is vital to raise the survival rate of patients. Methods The whole microarray datasets GSE83456 (training set) and GSE19444 (validation set) of TB patients were downlo…
He H, Zou Y, He J, Bu H, Liu Y
It is very difficult to diagnose and distinguish tuberculous meningitis, and the current laboratory methods are unsubstantial in developing countries. The study is aimed at creating a scoring system on the basis of basic laboratory and clinical achievements that could be used as …
Shah HD, Nazli Khatib M, Syed ZQ, Gaidhane AM, Yasobant S, et al.
Tuberculosis (TB) continues to be one of the important public health concerns globally, and India is among the seven countries with the largest burden of TB. There has been a consistent increase in the notifications of TB cases across the globe. However, the 2018 estimates envisa…
Kindie Fentahun Muchie, Frank Tobian, Mary Gaeddert, Claudia Maria Denkinger, Johanna Kellett Wright, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major global health challenge, with an estimated 10.8 million new cases and 1.25 million deaths in 2023. Despite advances in molecular detection of Mycobacterium TB (MTB), significant diagnostic gaps remain: in 2023, onl…
I Salles, E Lessem, L Walshe, B Myrzaliev, N B Hoa, et al.
…cases remain undiagnosed or unreported. Point-of-care (POC) diagnostics are critical for bridging this gap. **METHODS:** We surveyed stakeholder priorities for TB POC diagnostics to inform development aligned with global needs. An online survey was disseminated through SMART4TB …
Bony Wiem Lestari, Almira Alifia, Putu Wahyuni Wulandari Karnawati, Nurlaila Syahri Ramadhani, Selvia Kusdwiyanti, et al.
**BACKGROUND:** Throughout COVID-19 pandemic, many countries expanded their diagnostic infrastructure, including Indonesia. West Java, one of the most COVID-19-affected provinces in Indonesia, received many PCR machines during the pandemic but the molecular diagnostic landscape l…
Mukesh Singh, Manjeet Kumar Goyal, Himanshu Narang, Malambo Mubbunu, Peeyush Kumar, et al.
**BACKGROUND:** The differentiation between gastrointestinal tuberculosis (GITB) and Crohn's disease (CD) is challenging. Detection of urinary lipoarabinomannan (LAM), a glycolipid component of the Mycobacterium tuberculosis cell wall, has shown potential as a non-invas…
Muniyandi M, Lavanya J, Karikalan N, Saravanan B, Senthil S, et al.
Background The National Tuberculosis Elimination Programme (NTEP) of India is aiming to eliminate TB by 2025. The programme has increased its services and resources to strengthen the accurate and early detection of TB. It is important to estimate the cost of TB diagnosis in India…
Sossen B, Székely R, Mukoka M, Muyoyeta M, Nakabugo E, et al.
Background Diagnostic delays for tuberculosis are common, with high resultant mortality. Urine-Xpert Ultra (Cepheid) could improve time to diagnosis of tuberculosis disease and rifampicin resistance. We previously reported on lot-to-lot variation of the Fujifilm SILVAMP TB LAM. I…
Yadav S, Rawal G, Jeyaraman M, Jeyaraman N
…p and the hurdles encountered with traditional tuberculosis diagnostics. From there, it traces the journey of the Xpert MTB/RIF technology, underscoring its molecular underpinnings. In this narrative review, the performance of the Xpert MTB/RIF Ultra system undergoes thorough scr…
Darya Ebrahimi Moghaddam, Javid Sadri Nahand, Farah Bokharaei-Salim, Tahereh Donyavi, Fatemeh Ahmadi
Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection remain leading causes of mortality, especially in source-limited settings where diagnostic challenges impede timely management. Non-coding RNAs (ncRNAs) are emerging as non-invasive biomarkers for infectious di…
Sánchez-Cabral O, Martínez-Mendoza D, Flores-Bello ÁP, Martínez-Orozco JA, Rivera-Rosales RM, et al.
Background The key diagnostic method for the evaluation of lung diseases associated with HIV infection is bronchoscopy, with bronchoalveolar lavage (BAL) being the most commonly used sampling technique. Transbronchial biopsy (TBB) is often complementary. Setting This is a retrosp…
Maria Helena Favarato, Victoria Luisa Pereira Aguiar, Edison Ferreira Paiva, Leonardo Oliveira Mendonça
**BACKGROUND AND METHODS:** Recurrent fever is a complex clinical presentation that poses significant diagnostic challenges, particularly when no clear etiology emerges despite extensive investigation. This integrative narrative review provides a comprehensive overview of recurre…
Mahmoudi S, Nourazar S
Accurate tuberculosis (TB) diagnosis remains challenging, especially in resource-limited settings. This study aims to assess the diagnostic performance of the QIAreach QuantiFERON-TB (QFT) assay, with a specific focus on comparing its diagnostic performance with the QuantiFERON-T…
Hazratullah Bariz, Muhammad Haroon Stanikzai, Ghulam Mohayuddin Mudaser, Khalid Ahmad Stanikzai, Omid Dadras
**BACKGROUND:** Diagnostic delay among tuberculosis (TB) patients leads to late anti-TB treatment initiation, which is associated with poor prognosis and increased TB transmission. Despite its recognized negative consequences, diagnostic delay among TB patients is common in devel…
Ruvandhi R Nathavitharana, Abarna Pearl, Matthew O'Bryan, Matthew Edwards, Helene-Mari van der Westhuizen, et al.
…informed the WHO standard: Universal Access to Tuberculosis Diagnostics. **METHODS:** We searched multiple databases without language restrictions until 29 July 2022. We included studies that used qualitative, quantitative or mixed methods study designs. Four reviewers independe…
Dara M, Ehsani S, Mozalevskis A, Vovc E, Simões D, et al.
Globally, high rates (and in the WHO European region an increasing prevalence) of co-infection with tuberculosis and HIV and HIV and hepatitis C virus exist. In eastern European and central Asian countries, the tuberculosis, HIV, and viral hepatitis programmes, including diagnost…
Ai JW, Zhou X, Xu T, Yang M, Chen Y, et al.
Rapid and simple-to-use diagnostic methods for tuberculosis are urgently needed. Recent development has unveiled the diagnostic power of the CRISPR system in the detection of viral infections. However, its potential use in detecting the Mycobacterium tuberculosis complex (MTB) re…
Norbert Georg Schwarz, Ulrike Loderstaedt, Andreas Hahn, Rebecca Hinz, Andreas Erich Zautner, et al.
…uld not preclude developing countries from state of the art diagnostics.
O'Halloran C, Burr P, Gunn-Moore DA, Hope JC
The domestic dog ( Canis lupus familiaris ) is a competent host for Mycobacterium ( M. ) bovis infection but no ante mortem diagnostic tests have been fully validated for this species. The aim of this study was to compare the performance of ante mortem diagnostic tests across sam…
Walzl G, McNerney R, du Plessis N, Bates M, McHugh TD, et al.
…nts and key achievements in the search for new tuberculosis diagnostics and biomarkers. We highlight gaps and challenges in evaluation and rollout of new diagnostics and biomarkers, and prioritise areas needing further investment, including impact assessment and cost-benefit stud…