Showing 176–192 of 192 documents
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Harshad C Devarbhavi, Raúl J Andrade
…ave been implicated in most cases of acute liver failure in registry studies. **METHODS:** This review summarizes current knowdledge on the acute and chronic outcomes in patients with idiosyncratic DILI and discusses several of the existing prognostic models. **RESULTS AND CONC…
Calabrese LH, Calabrese C, Lenfant T, Kirchner E, Strand V
…nfectious complications were predictable in the light of preclinical models and early clinical trials (i.e., tuberculosis and TNF inhibitors; meningococcus; and eculizumab). While these scenarios can potentially help us in terms of enhancing our predictive powers (higher vigilanc…
Njovu IK, Nalumaga PP, Ampaire L, Nuwagira E, Mwesigye J, et al.
… will also collect baseline data, including demographic and clinical history, using a patient-reported questionnaire. Altogether, this approach will contribute to a diagnostic-based observational study. The primary outcome will be the overall fungal and bacterial diagnostic profi…
Nasur Buyinza, Kennedy Nkhoma, Eve Namisango, Matthew Maddocks, Julia Downing, et al.
…drug-resistant tuberculosis experience burdensome symptoms, clinical uncertainty, and high mortality. Palliative care is a designated essential health service under Universal Health Coverage. We aimed to test the hypothesis that receipt of additional nurse-led palliative care wou…
van den Elsen SH, Sturkenboom MG, Akkerman O, Barkane L, Bruchfeld J, et al.
…However, TDM is considered laborious and expensive, and the clinical benefit in MDR-TB has not been extensively studied. This observational multicentre study aims to determine the feasibility of centralised TDM and to investigate the impact of fluoroquinolone TDM on sputum conver…
Adas MA, Alveyn E, Cook E, Dey M, Galloway JB, et al.
… treatment-associated infection risk is essential to inform clinical decision-making. Areas covered We summarize current literature on infection rates among the licensed JAKi using published phase II/III trial results, post-licensing and registry data. Expert opinion licensed JAK…
Gupta-Wright A, Corbett EL, van Oosterhout JJ, Wilson D, Grint D, et al.
…pragmatic, multicentre, double-blind, randomised controlled trial in two hospitals in Malawi and South Africa. We included HIV-positive medical inpatients aged 18 years or more who were not taking tuberculosis treatment. We randomly assigned patients (1:1), using a computer-gener…
Bryan L Peacker, Jonathan C Hwang, Rebecca I Hartman
…uld consider either including these patients in prospective trials or attempting to collect data via registries to provide more clarity on the management of immunologically vulnerable patients with melanoma.
Lee H, Choi H, Sim YS, Park S, Kim WJ, et al.
…spective cohort studies have been conducted to evaluate the clinical characteristics of Korean patients with bronchiectasis, indicating an urgent need for cohort studies on bronchiectasis. Methods and analysis The Korean Multicenter Bronchiectasis Audit and Research Collaboration…
Oxlade O, Trajman A, Benedetti A, Adjobimey M, Cook VJ, et al.
…able and highly dependent on the setting. We have planned a trial of a standardised public health approach to strengthen the management of household contacts (HHCs) of newly diagnosed patients with pulmonary TB. Assessing costs related to approach is a secondary objective of the …
Samruddhi Suresh Yerunkar, Nicole Hildebrand, Daniel Strech
**OBJECTIVES:** Monitoring systems exist for clinical research transparency in high-income countries, but systematic assessment of these practices in global health (GH) research (GHR) is limited. We evaluated methods for monitoring GHR transparency and engagement. **DESIGN:** Cr…
Yanes-Lane M, Trajman A, Bastos ML, Oxlade O, Valiquette C, et al.
…scade of care for latent TB infection. A cluster randomized trial of a programmatic public health intervention to improve management of latent TB infection in household contacts was conducted in Rio de Janeiro. Interventions included contact registry, initial and in-service train…
van Wyk SS, Nliwasa M, Lu FW, Lan CC, Seddon JA, et al.
…B) is important to control the pandemic and improve patient clinical outcomes. To our knowledge, systematic reviews assessing the effectiveness, cost-effectiveness, acceptability, and feasibility of different DR-TB case-finding strategies to inform research, policy, and practice,…
Vidya Ganji, Bhushan Kamble, Farzana Mustafa, Naveen Ravi, U Madhusudhan, et al.
… Web of Science and Cochrane Central Register of Controlled Trials. The search items included "Corona virus disease 19", "impact of COVID-19", "SARS-CoV-2", "Tuberculosis", "TB and COVID-19 co-infection", "comorbidities", "prognosis", "incidence", "outcomes" and "risk factors" fo…
Camlin CS, Sheira LA, Kwena ZA, Charlebois ED, Agot K, et al.
…ng fishermen in Kenya. Methods The Owete cluster-randomised trial mapped the male social networks of fishermen in three communities along Lake Victoria in Siaya County, Kenya, and identified distinct social networks (clusters) with a highly connected, network-central man (promote…
Awad K, Jaam M, Awaisu A, Stewart D, Rathore HA, et al.
…hree electronic databases (PubMed, Embase, Cochrane), a RCT registry ClinicalTrial.gov, a peer-reviewed journal 'The Lancet Infectious Diseases', and the references of retrieved articles. Interventions delivered by pharmacists alone or as part of multidisciplinary teams were incl…
Fronteira I, Pacheco M, Schaltz-Buchholzer F, Ferrinho P
…s administered to all newborns in Portugal. In July 2016, a clinical guideline established that only children under 6 years belonging to high-risk groups should receive BCG. This might have prevented nonvaccinated children from developing trained immunological responses as effect…