Showing 176–200 of 200 documents
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Bukkems VE, Colbers A, Marzolini C, Molto J, Burger DM
…Although the separate effects of drug-drug interactions and pregnancy on antiretroviral drug pharmacokinetics have been widely studied and described, their combined effect is largely unknown. Physiological changes during pregnancy may change the extent or clinical relevance of a …
Ravindra Kumar Garg, Rajiv Garg, Akshaya Anand Agrawal, Sanjay Singhal, Raza Abbas Mahdi
…ars; 63.0% had no prior TB history. TB was diagnosed during pregnancy (56.2%) or postpartum (38.4%). Miliary TB (38.4%) and genital TB (27.4%) were most common; central nervous system (CNS) TB occurred in 13.7%. Microbiological confirmation was achieved in 38.4%. Anti-TB therapy …
Alene KA, Murray MB, van de Water BJ, Becerra MC, Atalell KA, et al.
…agement of multidrug-resistant tuberculosis (MDR-TB) during pregnancy is challenging, yet no systematic synthesis of evidence has accurately measured treatment outcomes. Objective To systematically synthesize treatment outcomes and adverse events among pregnant patients with MDR-…
Leevan Tibaijuka, Adeline A Boatin, Asiphas Owaraganise, Lisa M Bebell, Musa Kayondo, et al.
… deaths worldwide. We examined medical comorbidities during pregnancy at Mbarara Regional Referral Hospital (MRRH) in south-western Uganda. **METHODS:** We conducted a cross-sectional study at MRRH from January to December 2022. Each month, we randomly selected 200 women admitte…
Sacoor C, Payne B, Augusto O, Vilanculo F, Nhacolo A, et al.
…y found that fertility rate is high at age 20-24 years old. Pregnancy in the advanced age (>35 years of age) in this study was associated with higher poor outcomes such as miscarriage and stillbirth. The study also found high stillbirth rate indicating a need for increased attent…
Xiaoyan Gai, Hongbin Chi, Lin Zeng, Lixue Chen, Zikang Sheng, et al.
…etween the interferon-gamma release assay (IGRA) status and pregnancy outcomes in infertile women, with untreated "inactive" tuberculosis lesions observed on chest radiography, who are undergoingfertilization and embryo transfer (IVF-ET). **METHODS:** This ambispective cohort st…
Spencer C Darveau, Sharan Yadav, Kelly E Dooley, Jyoti S Mathad
…. There are limited data on drug-drug interactions, adverse pregnancy outcomes, and treatment success specifically in pregnant women living with HIV on ART but several new trials in pregnancy have recently been conducted. **OBJECTIVE:** To perform a comprehensive narrative revie…
Violet Chihota, Zainab Waggie, Vicky Cardenas, Kathy Mngadi, Felex Ndebele, et al.
…mong women who became pregnant, with drug exposure in early pregnancy. **METHODS:** Women were classified as exposed if conception occurred while taking study drug, and unexposed if conception occurred after the last dose. Outcomes included live birth, stillbirth or abortion. A …
Warachit W, Porntharukchareon T, Sunthornyothin S
Abstract Background: Cushing’s syndrome (CS) in pregnancy is a rare condition. Accurate diagnosis and appropriate treatment are necessary due to increased morbidity and mortality in the fetus and mother with active CS. However, hormonal changes during pregnancy and limitations in…
Guiyi Ji, Mengling Song, Yuhan Ma, Yunxing Fu, Linlin Song, et al.
…oup 2. **RESULTS:** TB-cured women had significantly lower pregnancy rates (OR 0.766, 95% CI 0.603-0.972) and clinical pregnancy rates (OR 0.710, 95% CI 0.552-0.912) across all ages. In Poseidon group 1, the TB-cured group exhibited an increased risk of ectopic pregnancy (aOR 2.…
Wickremsinhe MN, Little MO, Carter AS, Sullivan KA, Lyerly AD
…orbidities, and equitable study of newer medications during pregnancy. Methods We employed a keyword search of the International Clinical Trials Registry Platform to identify interventional HIV-related trials conducted with pregnant women between January 2001 and December 2015. R…
Lianjing Liang, Shitong Su, Lanya Peng, Hua Zhuang, Yao Chen, et al.
…d embryo transfer (IVF-ET) for patients facing infertility. Pregnancy induces substantial endocrine and immune alterations that may diminish immune function, consequently heightening vulnerability to Mycobacterium tuberculosis (M.tb) infection or reactivation. Hematogenous dissem…
Nisha Jacob, Emma Kalk, Alexa Heekes, Florence Phelanyane, Kim Anderson, et al.
…egnant women living with HIV (WLWH) initiating ART prior to pregnancy increased from 20.9% in 2010 to 71.1% in 2020. Of all pregnancies 17.1% (143 987/842 641) were HIV exposed and 16.3% (137 572/842 641) had a record of a child HIV outcome, of whom 3966 (2.9%) were HIV positive …
Yadav V, Sharma JB, Kachhawa G, Kulshrestha V, Mahey R, et al.
… illness and death from infectious disease. Tuberculosis in pregnancy has been associated with increased risks of prematurity and small for gestational age (SGA)infants.The present study is aimed to examine obstetrical and perinatal outcomes among women who had extra-pulmonary tu…
Awua-Boateng NY, Mohammed A, Aglanu LM, Acheampong G, Amuasi JH, et al.
…ternal morbidity and mortality. Diagnosis of the disease in pregnancy is usually challenging, as the symptoms may be attributed to the pregnancy. Little is known about the true burden of the disease and its associated risk factors among pregnant women. This study sought to assess…
Dorsamy V, Bagwandeen C, Moodley J
…round A significant cause of morbidity and mortality during pregnancy is maternal anaemia. The causes of anaemia and the sequelae are varied, and the prevention and management are public health challenges, especially in resource-limited settings and certain geographic locations. …
Walt MV, Masuku S, Botha S, Nkwenika T, Keddy KH
…nical practice is limited. The study reviewed treatment and pregnancy outcomes and birth outcomes of their new-born in a cohort of pregnant women with DR-TB from three MDR-TB hospitals during 2010 and 2018. Design/methods Data were extracted from: TB register and patient clinic n…
Walles J, Otero LG, Tesfaye F, Abera A, Jansson M, et al.
…ca, are disproportionately burdened by stillbirth and other pregnancy complications. Active tuberculosis increases the risk of pregnancy complications, but the association between latent tuberculosis infection (LTBI) and pregnancy outcomes is unknown. We explored the effect of la…
Escudero JN, Mecha J, Richardson BA, Maleche-Obimbo E, Matemo D, et al.
Background Pregnancy and human immunodeficiency virus (HIV) may influence tuberculosis infection detection using interferon (IFN)-γ release assay (QFT-Plus; Qiagen) and tuberculin skin test (TST). Methods Participants in Western Kenya underwent QFT-Plus and TST in pregnancy, 6 we…
Mathad JS, Savic R, Britto P, Jayachandran P, Wiesner L, et al.
Background Pregnancy increases the risk of tuberculosis and its complications. A 3-month regimen of weekly isoniazid and rifapentine (3HP) is safe and effective for tuberculosis prevention in adults and children, including those with HIV, but 3HP has not been evaluated in pregnan…
Gausi K, Wiesner L, Norman J, Wallis CL, Onyango-Makumbi C, et al.
…uding pregnant women. Yet, plasma isoniazid exposure during pregnancy, in the antiretroviral therapy era, has not been well-described. We investigated pregnancy-induced and pharmacogenetic-associated pharmacokinetic changes and drug-drug interactions between isoniazid and efavire…
Båtshake Y, Walles J, Winqvist N, Björkman P
Background Pregnancy has been associated with elevated incidence of tuberculosis (TB) disease. Since 2014, people living in Sweden with origin in TB-endemic countries have been offered screening for TB infection in antenatal care (ANC) using Quantiferon-TB assays. We assessed fac…
Kim HY, Dobra A, Tanser F
…s All pregnant women aged ≥15 years were followed-up during pregnancy and the first year postpartum in a population-based longitudinal demographic and HIV surveillance program in KwaZulu-Natal, South Africa, from 2000 to 2016. During the household surveys (every 4-6 months), each…
Yifan Chu, Jialiang Zhang, Luyao Wang, Jiaxin Xie, Jiayun Chen, et al.
…tent tuberculosis infection and ovarian reserve, as well as pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), remains poorly understood.A single-center, retrospective cohort study was conducted at the Reproductive Medicine and Genetics Cent…
Linzy V Rosen, Acadia M Thielking, Caitlin M Dugdale, Grace Montepiedra, Emma Kalk, et al.
…an immunodeficiency virus (PPWH) report conflicting adverse pregnancy outcome (APO) risks, international guidelines recommend TPT for PPWH. **METHODS:** We used a microsimulation model to evaluate 5 TPT strategies among PPWH receiving antiretroviral therapy in South Africa: No T…