Showing 176–200 of 200 documents
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Sunil Bajeja, Kandula Jayapaul, Poonam Gaur, Chinnem Rama Mohan, Abhinav Pathak, et al.
… problem around the world. This is especially true now that drug-resistant forms of TB like Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) are becoming more common. Traditional ways of diagnosing drug resistance take a lot of time and resources, which means they …
Yuanyuan Yu, Jie Cao, Hongqiu Pan, Hui Zhong, Xiaocui Wu, et al.
Bedaquiline (BDQ) has gradually become a core drug in drug-resistant tuberculosis (DR-TB) treatment, and the additional benefits of prolonging BDQ use remain unclear. Patients with DR-TB who received a BDQ-containing regimen from three Chinese clinical centers between 1 March 201…
Kazemian H, Heidari H, Heidari H, Kardan-Yamchi J, Ghafourian S, et al.
…ificant global public health threat. Besides extensive multidrug resistance, MTB possesses several properties for long-term viability in the host as well as stress adaptation and resistance in harsh conditions. The role of toxin-antitoxin (TA) systems in disseminating and maintai…
Xu G, Liu H, Jia X, Wang X, Xu P
…n health. Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key factor in formulating treatment regimen and evaluating the prognosis of TB. Compared with other drugs resistance, the RIF-R mechanism of Mycobacterium tuberculosis (M. tuber…
Degiacomi G, Sammartino JC, Sinigiani V, Marra P, Urbani A, et al.
…s one of the major causes of death related to antimicrobial resistance worldwide because of the spread of Mycobacterium tuberculosis multi- and extensively drug resistant (multi-drug resistant (MDR) and extensively drug-resistant (XDR), respectively) clinical isolates. To fight M…
Getachew Seid, Ayinalem Alemu, Getu Diriba, Betselot Zerihun, Gemechu Tadesse, et al.
…hallenge. Different reports were made on the concordance of drug-resistance profiles between the household contact and the purported index case. This study investigated the drug-resistance pattern concordance of the index-household contact pair in central Ethiopia. **METHOD:** A…
Yuchuan Zhao, Chenchen Zhang, Xuezhi Wang, Huiying Feng, Meiling Yu, et al.
**UNLABELLED:** The drug-resistant tuberculosis (TB) is a major public health problem worldwide. Capreomycin (Cm) has been used as an effective drug to treat multidrug-resistant tuberculosis (MDR-TB) since 1960s. Although Cm and amikacin (Am) are historically grouped as second-li…
Dong Y, Ou X, Zhao B, Wang Y, Liu Y, et al.
The diagnosis of drug-resistant tuberculosis (TB) by molecular testing of Mycobacterium tuberculosis drug resistance genes is becoming increasingly common clinically. However, M. bovis , as an uncommon pathogen of human TB, may interfere with the test results. A comprehensive und…
Mokrousov I, Sinkov V, Vyazovaya A, Pasechnik O, Solovieva N, et al.
…ype characterized by an unexpectedly high rate of extensive drug resistance (XDR). In the current study, next generation sequencing data were analysed to gain insight into genomic signatures underlying drug resistance of these strains. A total of 184 genomes of the Beijing early …
Mongia H, Mamnoon F, Silsarma A, Mahajan R, Dalal A, et al.
…ndividualised regimens for eligible patients with pulmonary drug-resistant tuberculosis (DR-TB); however, data for patients with drug-resistant extrapulmonary tuberculosis (EPTB) is extremely limited. This study documents the treatment outcomes and adverse events associated with …
Song QS, Zheng CJ, Wang KP, Huang XL, Tartakovsky M, et al.
…terature described radiological feature differences between drug-sensitive pulmonary tuberculosis (DS-PTB) and multidrug-resistant (MDR)-PTB were confounded by that MDR-PTB cases tend to have a longer history. Using history length matched DS-PTB and MDR-PTB cases from a well-defi…
T C, L N, Vo N, L N, Tg T, et al.
Background The increasing prevalence and incidence of Multi Drug Resistant Tuberculosis (MDR-TB) is as a result of the defaulting of treatment by patients. Worldwide, several factors that contribute to patients defaulting to tuberculosis treatment protocol have been identified. T…
Jan F, Wali S, Sadia S, Akbar MT, Akbar HS, et al.
Introduction Multidrug resistant TB (MDR-TB), defined as resistance to at least rifampicin and isoniazid together, has been rapidly spreading in recent years. In new pulmonary tuberculosis patients, rapid spread of MDR-TB and XDR-TB challenging the effectiveness of national TB co…
Gutiérrez-Aroca JB, Ruiz P, Vaquero M, Causse M, Casal M
Multidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in Córdoba (Spain) between 2001 and 2015. A total of 1,207 c…
Nwachukwu NO, Ulasi AE, Okoronkwo CU, Unegbu VN
Background Pre-extensively drug-resistant tuberculosis (Pre-XDR-TB), an emerging form of drug-resistant tuberculosis, is challenging efforts at tuberculosis control, leading to treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients and progression to extensive…
Daoyan Tang, Ba La, Jian-Qing He
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is associated with alterations in drug pharmacokinetics (PK), aberrant expression of efflux pump transporters, and genetic mutations. Polymorphisms in host genes encoding efflux pumps may affect drug concentrations, potentially …
Lee T, Lee SJ, Jeon D, Lee HY, Kim HJ, et al.
Background Drug-resistance surveillance (DRS) data provide key information for building an effective treatment regimen in patients with multidrug-resistant tuberculosis (MDR-TB). This study was conducted to investigate the patterns and trends of additional drug resistance in MDR-…
Zuhriyyah SA, Nugraha HG, Setiabudi D, Santoso P, Nataprawira HM
…ate and compare the CXR findings of children with pulmonary drug-resistant TB (DR-TB) and drug-sensitive TB (DS-TB) that could help in the evaluation and management of TB cases in children. Methods Retrospective analysis with cross-sectional approach was conducted in children ( R…
Kassa GM, Merid MW, Muluneh AG
Background Rifampicin and/or multidrug-resistant tuberculosis (RR/MDR-TB) remains an uncontrolled public health emergency that has been synergized by the recently increased person-to-person transmission in the community as primary RR/MDR-TB, which is defined as RR/MDR-TB in new T…
Ketema T, Tadesse M, Bonsa Z, Balay G, Kebede W, et al.
Background Early and accurate diagnosis of drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). The Xper…
Melat Hatiya, Yared Merid, Addis Mola, Fanuel Belayneh, Musa Mohammed Ali
… of TB and TB/HIV co-infection. The emergence and spread of drug-resistant TB present significant challenges to TB care and control efforts, particularly multi-drug-resistant TB, which poses a serious public health issue in low-income countries such as Ethiopia. This study aimed …
Farhat M, Cox H, Ghanem M, Denkinger CM, Rodrigues C, et al.
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-attributable deaths worldwide and is driven by both ongoing resistance acquisition and person-to-person transmission. Poor outcomes are exacerbated by late diagnosis and inadequate access t…
Parikshana Mathur, Pinky Choudhary, Rajkuberan Chandrasekaran, Ragini Singh, Hemant Kumar Daima
…nt even after the global initiatives and emergence of multi-drug resistance (MDR) strains have made the situation complicated. Herein, the exploitation of the same medications for several decades, ineffective drug administration, and insufficient patient follow-up are some of the…
Diriba G, Alemu A, Tola HH, Yenew B, Amare M, et al.
Background The rise of drug-resistant tuberculosis (DR-TB) has presented a substantial challenge to the national tuberculosis (TB) control program. Understanding the epidemiology of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) could help clinicians to adapt MDR-TB tre…
de Lourdes do Carmo Guimarães Diniz J, von Groll A, Unis G, Dalla-Costa ER, Rosa Rossetti ML, et al.
Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Myco…