Showing 176–200 of 200 documents
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Musisi E, Wamutu S, Ssengooba W, Kasiinga S, Sessolo A, et al.
Background In 2018, the tuberculosis molecular bacterial load assay (TB-MBLA), a ribosomal RNA-based test, was acknowledged by WHO as a molecular assay that could replace smear microscopy and culture for monitoring tuberculosis treatment response. In this study, we evaluated the …
Abhishek S, Ryndak MB, Choudhary A, Sharma S, Gupta A, et al.
Background Studies on human intraocular tuberculosis (IOTB) are extremely challenging. For understanding the pathogenesis of IOTB, it is important to investigate the mycobacterial transcriptional changes in ocular environment. Methods Mice were challenged intravenously with Mycob…
Muflihah H, Flórido M, Lin LCW, Xia Y, Triccas JA, et al.
…t protection against pulmonary infection with Mycobacterium tuberculosis. Immunity induced by subcutaneous immunization with BCG wanes and does not promote early recruitment of T cell to the lungs after M. tuberculosis infection. Delivery of Tuberculosis (TB) vaccines to the lung…
Ronge L, Sloot R, Du Preez K, Kay AW, Kirchner HL, et al.
…ween quantitative IFNγ response and degree of Mycobacterium tuberculosis exposure, infection and tuberculosis (TB) disease status in children. Methods We completed cross-sectional analysis of children (≤15 years) exposed to an adult with bacteriologically confirmed TB, 2007-2012 …
Li X, Sheng L, Tu J, Lou L
…o determine the bactericidal effect of nano silver and anti-tuberculosis drugs on drug-resistant Mycobacterium tuberculosis . Solid-state drug sensitivity tests with streptomycin (SM), isoniazid (INH), RIF, EMB, kanamycin (km), and ofloxacin (ofx) were carried out on H37Rv and di…
Chu AL, Lecca LW, Calderón RI, Contreras CC, Yataco RM, et al.
…hown that cigarette smoking increases the infectiousness of tuberculosis patients, the impact of smoking cessation on tuberculosis transmissibility has not been evaluated. Methods Between 2009 and 2012, we enrolled 4500 tuberculosis patients and followed 14 044 household contacts…
Rakotomanana F, Dreyfus A, Randrianarisoa MM, Raberahona M, Chevallier E, et al.
The incidence rate of tuberculosis in prisons is estimated to be 8 times greater than that in the general population in Madagascar. Our objectives were to estimate the prevalence of pulmonary tuberculosis and HIV infection among prisoners and to identify risk factors associated w…
Mehaffy C, Kruh-Garcia NA, Graham B, Jarlsberg LG, Willyerd CE, et al.
Identification of biomarkers for latent Mycobacterium tuberculosis infection and risk of progression to tuberculosis (TB) disease are needed to better identify individuals to target for preventive therapy, predict disease risk, and potentially predict preventive therapy efficacy.…
Nieuwenhuizen NE, Nouailles G, Sutherland JS, Zyla J, Pasternack AH, et al.
…ases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoidosis. Serum activin A levels were increased in TB patients compared to healthy controls, including those with positive tuberculin skin tests, an…
Guerrero-Bustamante CA, Dedrick RM, Garlena RA, Russell DA, Hatfull GF
The global health burden of human tuberculosis (TB) and the widespread antibiotic resistance of its causative agent Mycobacterium tuberculosis warrant new strategies for TB control. The successful use of a bacteriophage cocktail to treat a Mycobacterium abscessus infection sugges…
Wang W, Liu A, Liu X, You N, Wang Z, et al.
Substantial tuberculosis transmission occurs outside of households, and tuberculosis surveillance in schools has recently been proposed. However, the yield of tuberculosis outcomes from school contacts is not well characterized. We assessed the prevalence of Mycobacterium tubercu…
Amare W Tadesse, Noriah Maraba, Jason Alacapa, Katya Gamazina, Tanyaradzwa Dube, et al.
**BACKGROUND:** Tuberculosis remains a leading cause of death globally, particularly in countries with high tuberculosis and HIV burdens. Disruptions caused by the COVID-19 pandemic may have further impacted tuberculosis outcomes. This study examines on-treatment mortality and as…
Kim J, Keshavjee S, Atun R
Background Tuberculosis (TB) is a major global health burden, which has been inadequately addressed. This study aims to analyze different patterns and gaps of care along the care cascade across countries and to develop a model to examine the relationship between performance of tu…
Shuyin Qian, Xiangyun Wang, Bei Huang, Haiyan Lu, Cuicui Xu, et al.
…n latent categories of stigma among patients with pulmonary tuberculosis over time and their correlation with treatment adherence. **METHODS:** A total of 236 patients with pulmonary tuberculosis were selected as the research subjects using the convenience sampling method. The s…
Robert Akpata, Jean-Baptiste Ntakpe, Eugène Messou, Nathalie De Castro, Corine Chazallon, et al.
**BACKGROUND:** Tuberculosis is a severe disease, not only due to its lethality but also to a significant morbidity occurring in people living with HIV (PLWH). If factors associated to mortality, severe morbidity and unsuccessful treatment related to the host are well identified …
Robi DT, Teklemariam T, Gebreyes BG, Bogale A, Haile T, et al.
Bovine tuberculosis, caused by Mycobacterium bovis , is a chronic zoonotic disease that persists in Ethiopia despite global control efforts, impacting public health and the economy. However, little is known about the epidemiology of bovine tuberculosis in Southwest Ethiopia. This…
Teixeira LAA, Santos B, Correia MG, Valiquette C, Bastos ML, et al.
Background The duration of the protective effect of tuberculosis preventive therapy (TPT) is controversial. Some studies have found that the protective effect of TPT is lost after cessation of therapy among people with human immunodeficiency virus (HIV) in settings with very high…
Ge HB, Zhu J
…inical efficacy of Baihe Gujin decoction combined with anti-tuberculosis therapy in mitigating the symptoms of pulmonary tuberculosis and to measure the effect on the CD4+ CD25+ regulatory T cell (T reg ) ratio. Methods This randomized study enrolled patients with pulmonary tuber…
Ndzi EN, Nkenfou CN, Pefura EWY, Mekue LCM, Guiedem E, et al.
Diagnosis of tuberculosis still faces a lot of challenges and is one of the priorities in the field of tuberculosis management. Deciphering the complex tuberculosis pathogenicity network could provide biomarkers for diagnosis. We discussed the distribution of HLA-B17, -DQB and -D…
Banerjee S, Severn M
Tuberculosis (TB) is one of the top 10 causes of death, worldwide. Worldwide 10 million people developed TB in 2017, (i.e.,133 cases per 100,000).– However, only 6.4 million cases were reported to WHO, indicating that 36% of cases were undiagnosed or not reported. According to a …
Qiao YJ, Song XY, Zhang LD, Li F, Zhang HQ, et al.
Background Tuberculosis is among the most devastating infectious diseases worldwide. Spinal tuberculosis is not easy to detect at an early stage, which without effective treatment often leads to spinal deformity and spinal cord damage which in turn cause complications such as par…
Lanping Zhang, Wenjun He, Xiufen Wang, Xue Li, Jinghui Chang, et al.
**BACKGROUND:** Inadequate health knowledge of tuberculosis patients is one of the causes of poor adherence among tuberculosis patients in China's tuberculosis control. In this study, we will develop and validate the effectiveness of a large language model (LLM) to improve the he…
Khan AF, Sajjad A, Mian DA, Tariq MM, Jadoon UK, et al.
Background The occurrence of both tuberculosis (TB) and concomitant hepatitis B virus (HBV) is likely to be associated with poor patient outcomes and poor treatment response. Objective To assess whether tuberculosis patients with concomitant hepatitis B virus infection were prone…
Emily McNair, Shahanara Valawalkar, Samyra R Cox, Abhay Kadam, Gayatri Lele, et al.
**BACKGROUND:** Post-tuberculosis lung disease is a well-recognized sequela of pulmonary tuberculosis (PTB). Extra-pulmonary tuberculosis (EPTB) accounts for a quarter of the global tuberculosis burden; yet pulmonary sequelae in people treated for EPTB are unknown. **METHODS:** …
Moonan PK, Nair SA, Agarwal R, Chadha VK, Dewan PK, et al.
The End TB Strategy envisions a world free of tuberculosis-zero deaths, disease and suffering due to tuberculosis by 2035. This requires reducing the global tuberculosis incidence from >1250 cases per million people to <100 cases per million people within the next two decades. Ex…