Showing 151–175 of 200 documents
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Reta MA, Maningi NE, Fourie PB
…econd-line injectable drugs in drug-resistant Mycobacterium tuberculosis (MTB) isolated from culture-positive pulmonary tuberculosis (PTB) symptomatic attendees of spiritual holy water sites (HWSs) in the Amhara region. Patients and methods From June 2019 to March 2020, a cross-s…
Kessel J, Göymen E, Wolf T, Wetzstein N, Küpper-Tetzel C, et al.
Objectives Patients with open pulmonary tuberculosis (opTB) are subject to strict isolation rules. Sputum smear microscopy is used to determine infectivity, but sensitivity is lower than for culture. This study aimed to investigate the clinical relevance of this mismatch in conte…
Sweetland AC, Galea J, Shin SS, Driver C, Dlodlo RA, et al.
SETTING A global survey of National Tuberculosis Program (NTP) directors. OBJECTIVES To assess the perceived mental health needs of persons with tuberculosis (TB), current practices, and receptivity to integrating evidence-based mental and substance use treatment into national TB…
Genestet C, Refrégier G, Hodille E, Zein-Eddine R, Le Meur A, et al.
Objectives Mycobacterium tuberculosis (Mtb) infections result in a wide spectrum of clinical presentations but without proven Mtb genetic determinants. Herein, we hypothesized that the genetic features of Mtb clinical isolates, such as specific polymorphisms or microdiversity, ma…
Kareem AI, Malan SF, Joubert J
The treatment and management of tuberculosis (TB) is a major global concern. Approved drugs for the treatment of TB, to date, have displayed various modes of action which can be grouped into radical releasing and non-radical releasing anti-TB agents. Radical releasing agents are …
Panova AE, Vinokurov AS, Shemetova AA, Burmistrova IA, Shulgina MV, et al.
Background High burden of drug-resistant (DR) tuberculosis (TB) is a significant threat to national TB control programs all over the world and in the Russian Federation. Different Mycobacterium tuberculosis (MTB) genotypes are hypothesized to have specific characteristics affecti…
Emelia Konadu Danso, Prince Asare, Amanda Yaa Tetteh, Phillip Tetteh, Augustine Asare Boadu, et al.
Drug-resistant (DR) tuberculosis (TB) and diabetes mellitus (DM) are intersecting epidemics that complicate management of both diseases and worsen patient outcomes. We conducted a prospective cohort study of 758 GeneXpert-confirmed pulmonary TB patients, of whom 75 had DM. Demogr…
Melat Hatiya, Yared Merid, Addis Mola, Fanuel Belayneh, Musa Mohammed Ali
**BACKGROUND:** Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) and is the second leading cause of death from contagious diseases worldwide. Ethiopia is among the 30 countries with the highest burden of TB and TB/HIV co-infection. The emergen…
Imperiale BR, García A, Minotti A, González Montaner P, Moracho L, et al.
…in-22 (IL-22) in the pathogenesis or tissue repair in human tuberculosis (TB) remains to be established. Here, we aimed to explore the ex-vivo and in-vitro T helper 22 (Th22) response in TB patients and healthy donors (HD) induced by different local multi-drug-resistant (MDR) Mvc…
Ejo M, Torrea G, Uwizeye C, Kassa M, Girma Y, et al.
…ectives This study described the population structure of M. tuberculosis complex (MTBc) strains among patients with pulmonary or lymph node tuberculosis (TB) in Northwest Ethiopia and tested the performance of culture isolation and MPT64-based speciation for Lineage 7 (L7). Metho…
Alemayehu A, Wassie L, Alemayehu DH, Adnew B, Neway S, et al.
Background Clinically diagnosed pulmonary tuberculosis (TB) (CDPTB) patients account for a huge proportion of TB. However, little is known about the genetic diversity and drug resistance profile of Mycobacterium tuberculosis Complex (MTBC) strains in this group of patients. Metho…
Sun W, Gui X, Wu Z, Zhang Y, Yan L
…rug resistance profile of multidrug-resistant mycobacterium tuberculosis (MDR-MTB) from newly diagnosed cases in China. Methods We validated the Phenotypic drug Sensitivity Test (pDST) for 12 anti-tuberculosis drugs using the Bactec MGIT 960 system. We described the characteristi…
Salaam-Dreyer Z, Streicher EM, Sirgel FA, Menardo F, Borrell S, et al.
… susceptibility) accounts for 38% of all rifampin-resistant tuberculosis (RR-TB) in South Africa and is increasing. We aimed to compare RMR-TB with multidrug-resistant TB (MDR-TB) in a setting with high TB, RR-TB, and HIV burdens. Patient-level clinical data and stored RR Mycobac…
Chiang CY, Lin CJ
National tuberculosis programmes (NTPs) should aim for achieving a very high proportion of cure of all tuberculosis (TB) cases. Ineffective chemotherapy of TB that keeps a substantial proportion of patients alive without cure may amplify resistance during treatment and promote tr…
Hai HT, Vinh DN, Thu DDA, Hanh NT, Phu NH, et al.
…l load assay (MBLA) rapidly quantifies viable Mycobacterium tuberculosis (Mtb) and may be useful for monitoring treatment response and treatment efficacy. We conducted a prospective study in 56 adults with pulmonary tuberculosis from whom 244 sputum samples were collected before …
Wu C, Yi H, Hu Y, Luo D, Tang Z, et al.
Objective To determine the effects of second-line anti-tuberculosis (TB) drugs on the composition and functions of intestinal microbiota in patients with rifampicin-resistant TB (RR-TB). Methods In this cross-sectional study, stool samples and relevant clinical information were c…
Kayomo MK, Hasker E, Aloni M, Nkuku L, Kazadi M, et al.
After an alert regarding ≈31 tuberculosis (TB) cases, 3 of which were rifampin-resistant TB cases, in Mbuji-Mayi Central Prison, Democratic Republic of the Congo, we conducted an outbreak investigation in January 2015. We analyzed sputum of presumptive TB patients by using the Xp…
Onyenaka C, Idowu KA, Ha NP, Graviss EA, Olaleye OA
Despite the recent progress in the diagnosis of tuberculosis (TB), the chemotherapeutic management of TB continues to be challenging. Mycobacterium tuberculosis ( Mtb ), the etiological agent of TB, is classified as the 13th leading cause of death globally. In addition, 450,000 p…
Hameed S, Mahmood N, Chaudhry MN, Ahmad SR, Aqeel Ur Rahman M, et al.
…reated-TB patients and risk factors associated in spread of tuberculosis are investigated in the current study. A total 244 Mycobacterium tuberculosis isolates were used for drug-susceptibility test against four drugs. Environmental risk factors were assessed by using self-design…
Fox GJ, Nguyen CB, Nguyen TA, Tran PT, Marais BJ, et al.
Introduction Treatment of latent tuberculosis infection (LTBI) plays a substantial role in the prevention of drug-susceptible tuberculosis (TB). However, clinical trials to evaluate the efficacy of preventive therapy for presumed multidrug-resistant (MDR) LTBI are lacking. This t…
Cheng Q, Xie L, Wang L, Lu M, Li Q, et al.
Objectives The impact of tuberculosis (TB) history on the risk of multidrug-resistant tuberculosis (MDR-TB) is not yet fully understood. We aimed to identify the impact of different TB history at the onset of future MDR-TB. Methods A large, retrospective, population-based cohort …
R Lia Kusumawati, Mirzan Hasibuan, Indah Nur Lestari, Delyuzar, Nisrina Tari
**BACKGROUND:** Tuberculosis (TB) remains a major global health challenge. In addition to Mycobacterium tuberculosis (MTB), nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of mycobacterial infections. However, the limited access to rapid diagnost…
Verma A, Naik B, Kumar V, Mishra S, Choudhary M, et al.
Tuberculosis (TB) is a global health threat that causes significant mortality. This review explores chemotherapeutics that target essential processes in Mycobacterium tuberculosis , such as DNA replication, protein synthesis, cell wall formation, energy metabolism, and proteolysi…
Brown TS, Tang L, Omar SV, Joseph L, Meintjes G, et al.
…ns to undermine advances in the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial Mycobacterium tuberculosis (Mtb) isolates collected during BDQ-based treatment can provide insights into the etiologies of BDQ resistance in this important group of DRTB patient…
Hansraj Choudhary, Garima Malik, Devendra Singh Chauhan, Manpreet Bhalla, Azger Dusthackeer, et al.
Background & objectives Tuberculosis (TB) remains a major global health concern, with India accounting for 26 per cent of the global burden. Despite advances, access to rapid molecular diagnostics is limited, and the assays currently used in National TB Elimination Programme (NTE…