Showing 151–175 of 200 documents
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Adekambi T, Ibegbu CC, Cagle S, Ray SM, Rengarajan J
Antigen-specific CD4 + T cell responses to Mycobacterium tuberculosis (Mtb) infection are important for host defense against tuberculosis (TB). However, Mtb-specific IFN-γ-producing T cells do not distinguish active tuberculosis (ATB) patients from individuals with asymptomatic l…
Tsasse MAF, Dilonga Meriki H, Nana Djeunga HC, Ngwa MA, Tatsilong Pambou HO, et al.
Bovine tuberculosis (bTB), a neglected zoonotic disease, is endemic in cattle in many Sub-saharan African countries, yet its contribution to tuberculosis (TB) burden is understudied. Rapid urbanisation and increase in demand for animal proteins, including dairy products, increase…
Kroidl I, Ahmed MIM, Horn S, Polyak C, Esber A, et al.
Background Early detection of asymptomatic incipient tuberculosis (TB) could improve clinical outcomes and reduce the spread of Mycobacterium tuberculosis (MTB) infection, particularly in HIV endemic settings. This study assessed TB disease activity over 5 years in people living …
Abadir AP, Han JY, Youssef FA
Intestinal tuberculosis (ITB) and Crohn's disease (CD) very closely resemble each other in symptomatology, imaging, appearance, and pathology. While ITB is rare in the United States, its prevalence is significantly higher in endemic areas, thus presenting a diagnostic dilemma in …
Huang Y, Tang J, Cai Z, Qi Y, Jiang S, et al.
… intestinal microbiota at different stages of Mycobacterium tuberculosis infection. Methods Fecal samples of 19 active tuberculosis (ATB) patients, 21 latent tuberculosis infection (LTBI) individuals, and 20 healthy controls (HC) were collected. Gut microbiota of all the particip…
Chattu VK, Sakhamuri S, Motilal S, Pounder LJ, Persad VK, et al.
Globally, a quarter of the population is infected with tuberculosis (TB), caused by Mycobacterium tuberculosis . About 5-10% of latent TB infections (LTBI) progress to active disease during the lifetime. Prevention of TB and treating LTBI is a critical component of the World Heal…
Muchuro S, Makabayi-Mugabe R, Musaazi J, Mayito J, Zawedde-Muyanja S, et al.
The World Health Organization recommends the scale-up of tuberculosis preventive therapy (TPT) for persons at risk of developing active tuberculosis (TB) as a key component to end the global TB epidemic. We sought to determine the feasibility of integrating testing for latent TB …
Yan WJ, Zhou HY, Yan H
Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis that usually affects the lungs. Timely treatment of active TB, diagnosis and prevention of latent TB are very important. However, extrapulmonary TB affects almost any tissues around the eye and orbit,…
Oh JH, Ham SP, Park HJ
…s is favorable, primary infection or reactivation of latent tuberculosis (TB) is the major concern in the setting of tumor necrosis factor-alpha inhibitor therapy. Therefore, the treatment of latent tuberculosis infection (LTBI) before starting biologics is mandatory to prevent t…
Huang Y, Tang J, Cai Z, Qi Y, Jiang S, et al.
… intestinal microbiota at different stages of Mycobacterium tuberculosis infection. Fecal samples of 19 active tuberculosis (ATB) patients, 21 latent tuberculosis infection (LTBI) individuals, and 20 healthy controls (HC) were collected. Gut microbiota of all the participants wer…
Smith AGC, Kempker RR, Wassie L, Bobosha K, Nizam A, et al.
…tain whether diabetes affects the risk of developing latent tuberculosis infection (LTBI) following exposure to Mycobacterium tuberculosis ( Mtb ). We assessed the relationship of diabetes or prediabetes and LTBI among close and household contacts (HHCs) of patients with active p…
Valerie Vinette, Anthony Castro, Heather Kim, Carolina Trujillo, Min Xie, et al.
…(AMs) are the first immune cells to encounter Mycobacterium tuberculosis (Mtb) in the lungs, but they frequently fail to eliminate this causative agent of tuberculosis (TB), allowing Mtb to persist or replicate. Interstitial macrophages (IMs) are recruited to restrict Mtb growth …
Zhou Y, Lan H, Shi H, Wu P, Zhou Y
Tuberculosis (TB) is a leading global public health problem; however, the mechanisms underlying the immunopathology of TB progression are not well understood. It is currently believed that Mycobacterium tuberculosis (Mtb) infection can modify natural killer (NK) cell phenotypic s…
Mutua F, Su RC, Mesa C, Lopez C, Ball TB, et al.
…-induced genes have the potential for distinguishing active tuberculosis (ATB) from latent TB infection (LTBI) and healthy controls (HC), monitoring treatment, and detection of individuals at risk of progression to active disease. We examined the differential effects of IFN-α, IF…
Magdalena D, Michal S, Marta S, Magdalena KP, Anna P, et al.
Profound tuberculosis (TB)-induced metabolic changes reflected in the blood metabolomic profile may provide an opportunity to identify specific markers of Mycobacterium tuberculosis infection. Using targeted liquid chromatography tandem mass spectrometry, we compared the levels o…
Horsburgh CR, Jo Y, Nichols B, Jenkins HE, Russell CA, et al.
Background Modeling studies have concluded that 60-80% of tuberculosis (TB) infections result from reinfection of previously infected persons. The annual rate of infection (ARI), a standard measure of the risk of TB infection in a community, may not accurately reflect the true ri…
Mantei A, Meyer T, Schürmann M, Beßler C, Bias H, et al.
Background Rapid and reliable diagnostic work-up of tuberculosis (TB) remains a major healthcare goal. In particular, discrimination of TB infection from TB disease with currently available diagnostic tools is challenging and time consuming. This study aimed at establishing a sta…
Sangma VSC, Jaggi S, Saini V, Aggarwal D, Kumar P, et al.
Treatment of latent pulmonary tuberculosis (TB) in household contacts has been included in the National Tuberculosis Elimination Program to achieve the target of TB elimination by the Government of India by 2025. However, there are no clear estimates of the prevalence of latent T…
Kim S, Wu X, Hughes MD, Upton C, Narunsky K, et al.
…ation is an important strategy to identify individuals with tuberculosis (TB) exposure, infection and disease, including those who may benefit from tuberculosis preventive therapy (TPT). Data in children exposed to rifampin-resistant TB are limited. Methods In preparation for and…
Vecchione MB, Angerami MT, Suarez GV, Turk G, Laufer N, et al.
…ction is a major risk factor predisposing for Mycobacterium tuberculosis infection and progression to active tuberculosis (TB). As host immune response defines the course of infection, we aimed to identify immuno-endocrine changes over six-months of anti-TB chemotherapy in HIV+ p…
Duffy D, Nemes E, Llibre A, Rouilly V, Musvosvi M, et al.
Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) infection and is a major public health problem. Clinical challenges include the lack of a blood-based test for active disease. Current blood-based tests, such as QuantiFERON (QFT) do not distinguish active…
Bhosale R, Alexander M, Deshpande P, Kulkarni V, Gupte N, et al.
Background Accurate tuberculosis infection (TBI) tests are critical for pregnant women, especially those with HIV, who have a high risk of TB disease. Methods We enrolled interferon gamma release assay (IGRA)+ pregnant women with and without HIV in a longitudinal study, followed …
Yadav J, Phogat S, Chaudhary D, Jaiwal R, Jaiwal PK
…oved vaccine, Bacillus Calmette Guérin (BCG) used in global tuberculosis (TB) immunization programmes has been very effective in childhood TB but not in adult pulmonary and latent TB. Moreover, the emergence of multi-drug resistance-TB cases demands either to increase efficiency …
Velayati AA, Mitaria S, Farnia P, Farnia P, Ghanavi J, et al.
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), can enter a dormant phase within host tissues, complicating treatment and highlighting the need to investigate the genetic changes associated with dormancy. Methods This study examined clinical isolates of …
Schwalb A, Emery JC, Dale KD, Horton KC, Ugarte-Gil CA, et al.
A key metric in tuberculosis epidemiology is the annual risk of infection (ARI), which is usually derived from tuberculin skin test (TST) and interferon-γ release assay (IGRA) prevalence surveys carried out in children. Derivation of the ARI assumes that immunoreactivity is persi…