Showing 151–175 of 200 documents
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Shleider Carnero Canales C, Marquez Cazorla J, Furtado Torres AH, Monteiro Filardi ET, Di Filippo LD, et al.
…propelled research into diagnostic tests based on molecular diagnostics, pulmonary immunity, epigenetics, metabolomics, and a current focus on next-generation MTB antigen-based skin test (TBST). It is within these emerging methods that the potential for accurate distinction betwe…
George W Kasule, Sabine Hermans, Sozinho Acacio, Alexander Kay, Joachim Kikoyo Nsubuga, et al.
**BACKGROUND:** When people living with HIV develop pulmonary tuberculosis, it often manifests without detectable acid-fast bacilli on sputum microscopy. We aimed to assess the diagnostic accuracy of stool Xpert MTB/RIF Ultra (hereafter, Ultra) for Mycobacterium tuberculosis dete…
Seid Ahmed Hassen, Hanan Yusuf Ahmed, Dawit Kebede Huluka, Aschalew Worku Ashagre, Mahfuz Ahmed Ibrahim, et al.
**BACKGROUND:** Fiberoptic bronchoscopy is an essential diagnostic tool for infectious diseases such as tuberculosis and non-infectious conditions, including lung cancer, allowing direct visualization of the airways and tissue sampling. Given the high morbidity and mortality asso…
G McNally, D Solomon, M Brown, S Capocci, D Creer, et al.
…y score, using results of mycobacterial cultures, molecular diagnostics, microscopy, histology, clinical and radiology results, to grade cases on a 1-5 scale. Since 2017, this has been routinely used as part of our quarterly patient Cohort Reviews. We evaluated the relationship b…
Wang C, Lou C, Yang Z, Shi J, Niu N
Objectives This study aimed to conduct a non-targeted metabolomic analysis of plasma from patients with spinal tuberculosis (STB) to systematically elucidate the metabolomic alterations associated with STB, and explore potential diagnostic biomarkers for STB. Methods From January…
Dodd PJ, Pennington JJ, Bronner Murrison L, Dowdy DW
…agnosis and its role in simplifying a model of tuberculosis diagnostics. Results When diagnostic delays were short relative to recovery rates, our approximation provided a good account of infection dynamics and the cumulative costs of diagnosis and treatment. Proportional errors …
Wako WG, Wasie A, Wayessa Z, Fikrie A
Background Unrecognised transmission of tuberculosis is a main contributor of high epidemic of tuberculosis in low-income countries. Studies done in Ethiopia showed that delay in tuberculosis diagnosis and treatment is one of the major challenges to tuberculosis control programme…
A Manoharan, K Perialathan, L Krisnan, W M Koh, C H Teo, et al.
**BACKGROUND:** Chronic cough (CC), defined as a cough persisting for over eight weeks, presents diagnostic and management challenges in primary care, particularly in tuberculosis (TB)-endemic countries like Malaysia. This study aimed to assess the knowledge, practices and diagno…
Drain PK, Niu X, Shapiro AE, Magcaba ZP, Ngcobo Z, et al.
Background Development of a non-sputum test using readily-obtainable biospecimens remains a global priority for tuberculosis (TB) control. We quantified lipoarabinomannan (LAM) concentrations, a pathogen biomarker for Mycobacterium tuberculosis, in urine, plasma and serum for rea…
Wenxuan Li, Juan Lei, Ying Zhang, Libo Liang, Xiaolin Wang, et al.
**OBJECTIVE:** We aimed to investigate the effect of first visit to different levels of medical institutions on diagnostic and treatment delays of pulmonary tuberculosis (PTB) patients, assess the current situation and potential problems of different-level medical institutions, a…
Hongxia Yan, Hongfei Duan, Xiaoxu Han, Jin Sun, Qingtao Liang, et al.
**INTRODUCTION:** Diagnosing tuberculosis (TB) in HIV-infected individuals presents significant challenges due to difficulties in obtaining specimens containing adequate quantities of(). This study aimed to evaluate the diagnostic performance of themRNA assay independently and in…
Sohail AH, Khan MS, Sajan A, Williams CE, Amodu L, et al.
Introduction Peritoneal tuberculosis is difficult to diagnose as it may mimic peritoneal carcinomatosis, which has similar symptomatology. We sought to determine the diagnostic accuracy of computed tomography in differentiating peritoneal tuberculosis versus peritoneal carcinomat…
Turner CT, Gupta RK, Tsaliki E, Roe JK, Mondal P, et al.
Background Blood transcriptional signatures are candidates for non-sputum triage or confirmatory tests of tuberculosis. Prospective head-to-head comparisons of their diagnostic accuracy in real-world settings are necessary to assess their clinical use. We aimed to compare the dia…
Sara Benevento, Niccolò Riccardi, Giovanni Fumagalli, Luigi Ruffo Codecasa, Giovanni Sotgiu
Tuberculosis (TB) remains a leading cause of infectious-disease-related morbidity and mortality worldwide, including in low-incidence, high-income countries, where cases increasingly cluster among vulnerable populations. In these settings, persistent diagnostic and treatment dela…
Linsheng Li, Peilong Wang, Zhiming Li, Guangliang Bai, Zhaoyang Ye, et al.
…s a persistent challenge in global TB control, with current diagnostics failing to reliably distinguish these states or predict progression. This study introduces the HeptaTB Dx Model, the first diagnostic signature derived from the crosstalk between cuproptosis and ferroptosis-t…
Ananthasayanam JR, Saravanan J, Gunasekaran D, Meganathan S, Natarajan P
Background Lung masses pose a significant diagnostic challenge due to their diverse causes, from benign hamartomas to malignant bronchogenic carcinoma. Multi-detector CT (MDCT) is essential in evaluating these masses, offering detailed morphological insights to help differentiate…
Zhou R, Sun X, Guo M, Zhang H, Chen X, et al.
Aim The diagnosis of inflammatory bowel disease (IBD) worldwide is complicated and results in diagnostic delay. However, the diagnostic interval of IBD and the factors associated with diagnostic delay in patients in China have not been determined. Methods We retrospectively analy…
Xiufeng Huang, Hongxing Li, Lu Liu, Yu Zhang
**OBJECTIVE:** This study aimed to assess the auxiliary diagnostic efficacy of Pentraxin 3 (PTX3) as a biomarker for pulmonary tuberculosis (TB) by analyzing its levels in plasma and bronchoalveolar lavage fluid (BALF) in TB patients. Given the limitations of current TB diagnosti…
Engel N, Krumeich A
…d in development and implementation of tuberculosis and HIV diagnostics, to examine how norms and values of what constitutes a good point-of-care diagnostic are operating in practice through both top-down and bottom-up dynamics. It draws the link between design, evidence and adop…
Luo Y, Xue Y, Lin Q, Mao L, Tang G, et al.
Background The differential diagnosis between tuberculous meningitis (TBM) and bacterial meningitis (BM) remains challenging in clinical practice. This study aimed to establish a diagnostic model that could accurately distinguish TBM from BM. Methods Patients with TBM or BM were …
Jehangir M, Parry AH, Wani SH, Kadla S, Sheikh B
Purpose Ileocolonoscopy aids in the diagnosis of ileocecal region pathologies when typical mucosal lesions are seen. However, in many cases the mucosal lesions of the ileocaecal region are atypical, rendering themselves to diagnostic dilemma. The present study aimed to study the …
Shimoda M, Tanaka Y, Ohe T, Ishiguro T, Suzuki A, et al.
Introduction Adenosine deaminase (ADA) in pleural fluid is a useful marker for diagnosing tuberculous pleurisy. However, recent studies have reported a lower specificity of pleural fluid ADA levels. We previously developed a diagnostic flowchart for patients with pleural fluid AD…
Jouego CG, Collins TN, Tegomoh B, Geenen C, Netongo PM, et al.
Since 2012, Cameroon has introduced rapid molecular diagnostic tests for tuberculosis (TB). Despite this progress, WHO estimates indicate a TB diagnostic gap of 43% at the national level in 2019. This raises questions about the strategic allocation of available rapid molecular di…
Xie Z, Wang T, Chen H, Wang D, Gao X, et al.
Background Recurrent tuberculosis (TB) contributes to the burden of TB. The study was designed to explore the time of diagnostic delay and risk of delay in patients with recurrent TB in China. Methods A total of 13,334 patients with new and recurrent TB registered in Yulin a city…
Takwoingi Y, Whitworth H, Rees-Roberts M, Badhan A, Partlett C, et al.
Background Interferon gamma release assays (IGRAs) are blood tests recommended for the diagnosis of tuberculosis (TB) infection. There is currently uncertainty about the role and clinical utility of IGRAs in the diagnostic workup of suspected active TB in routine NHS clinical pra…