Showing 151–175 of 192 documents
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Inbaraj LR, Shewade HD, Daniel J, Srinivasalu VA, Paul J, et al.
… for the studies to be included were; randomized controlled trials or cohort studies that focused on adults with Isoniazid mono-resistant tuberculosis (HrTB) and treated with a Levofloxacin-containing regimen along with first-line anti-tubercular drugs; they should have had a con…
Fu L, Feng Y, Ren T, Yang M, Yang Q, et al.
…ever studied for LTBI. This proof-of-concept study (Chinese Clinical Trials Registry number: ChiCTR2200058346) was the first to explore a novel, rapid, and simple LTBI detection method via breath test on high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS…
Giller DB, Giller BD, Giller GV, Scherbakova GV, Koroev VV, et al.
…d active TB absence verified with computed tomography (CT). Clinical improvement (sputum negativity, closure of caverna, and lack of reactivation for 3 years) was achieved in 81% of cases. Conclusions Comparing the successful results of this technique in the cohort of multidrug-r…
Marcy O, Wobudeya E, Font H, Vessière A, Chabala C, et al.
…ortality. Methods We did a stepped-wedge cluster-randomised trial in 16 hospitals from six countries (Cambodia, Cameroon, Côte d'Ivoire, Mozambique, Uganda, and Zambia) with high incidence of tuberculosis. Children younger than 5 years with WHO-defined severe pneumonia received e…
Stefan Fabian Weber, Anne Glaser, Bayodé Roméo Adegbite, Jabar Babatunde Pacome Agbo Achimi Abdul, Guy Arnault Rogue Mfoumbi Ibinda, et al.
…uartile range 28-57). PTB was confirmed in 34 of 103 (33%), clinically diagnosed in 5 of 103 (5%), and not diagnosed in 62 of 103 (62%). In the non-TB group, CXR findings were consistent with bacterial pneumonia (24/62, 39%) or malignancy (12/62, 19%). At follow-up, 81 of 100 (81…
Padmapriyadarsini C, Das M, Burugina Nagaraja S, Rajendran M, Kirubakaran R, et al.
…ods We conducted a literature search for randomized control trials, cohort studies, and case reports of chemoprophylaxis for pediatric contacts of MDR-TB patients in PubMed, EMBASE, Cochrane Databases of Systematic Reviews, metaRegister of Controlled Trials, and other clinical re…
Singh S, Diwakar A, Singh RK
… withdrawal of BCG vaccination mandates from developed industrialized countries while reducing to a single neonatal shot in the rest. Concurrently, a steady increase in early childhood Brain and CNS (BCNS) tumors has occurred. Though immunological causes of pediatric BCNS cancer …
Ndege R, Ngome O, Vanobberghen F, Bani F, Temba Y, et al.
…ts with suspected extrapulmonary tuberculosis. Methods This trial in adults with suspected extrapulmonary tuberculosis was performed in a rural and an urban hospital in Tanzania. Participants were randomized 1:1 to intervention or routine care, stratified by site and HIV status. …
Maraba N, Orrell C, Chetty-Makkan CM, Velen K, Mukora R, et al.
…andard of care clinics will be conducted. Significance This trial will provide evidence for the use of an intervention, including medication monitors and differentiated care package, to improve adherence to TB treatment. Improved adherence should also improve TB treatment complet…
Bogers SJ, Schim van der Loeff MF, Davidovich U, Boyd A, van der Valk M, et al.
…iated with a prevalence of undiagnosed HIV > 0.1%, or whose clinical management would be impeded if an HIV infection were undiagnosed. IC-guided HIV testing is an effective strategy in identifying undiagnosed HIV, but opportunities for earlier HIV diagnosis through IC-guided test…
Story A, Aldridge RW, Smith CM, Garber E, Hall J, et al.
…icentre, analyst-blinded, randomised controlled superiority trial in 22 clinics in England (UK). Eligible participants were patients aged at least 16 years with active pulmonary or non-pulmonary tuberculosis who were eligible for DOT according to local guidance. Exclusion criteri…
Jonas DE, Riley SR, Lee LC, Coffey CP, Wang SH, et al.
…USPSTF). Data sources PubMed/MEDLINE, Cochrane Library, and trial registries through December 3, 2021; references; experts; literature surveillance through January 20, 2023. Study selection English-language studies of LTBI screening, LTBI treatment, or accuracy of the tuberculin …
Sweeney S, Gomez G, Kitson N, Sinha A, Yatskevich N, et al.
…mic evaluation (PRACTECAL-EE substudy) alongside an ongoing clinical trial (TB-PRACTECAL) aiming to assess the costs to patients and providers of new regimens, as well as their cost-effectiveness and impact on participant poverty levels. This substudy is based on data from the th…
Mukora R, Maraba N, Orrell C, Jennings L, Naidoo P, et al.
…heir treatment journey and help overcome TB-related stigma. Trial registration number Pan African Trial Registry PACTR201902681157721.
Seddon JA, Garcia-Prats AJ, Purchase SE, Osman M, Demers AM, et al.
…y could reduce the risk of disease progression. To date, no trials of MDR-TB preventive therapy have been completed and World Health Organization guidelines suggest close observation with no active treatment. Methods The tuberculosis child multidrug-resistant preventive therapy (…
Loan JJM, Poon MTC, Tominey S, Mankahla N, Meintjes G, et al.
…ify prognostic indicators, we aimed to compare survival and clinical outcome following VPS placement between all studied causes of hydrocephalus in HIV infected patients. Methods The following electronic databases were searched: The Cochrane Central Register of Controlled Trials,…
David B Meya, Fiona V Cresswell, Biyue Dai, Nicole Engen, Kogieleum Naidoo, et al.
…We performed a double-blind, randomized, placebo-controlled clinical trial involving adults with tuberculous meningitis in Indonesia, South Africa, and Uganda. We assigned persons with and those without human immunodeficiency virus (HIV) coinfection to receive standard daily ison…
Moriarty AS, Louwagie GM, Mdege ND, Morojele N, Tumbo J, et al.
…ng and alcohol, and poor adherence to medication can affect clinical outcomes. Modification of these behaviours is likely to improve TB treatment outcomes and has proven possible using motivational interviewing (MI) techniques or use of short message service (SMS) text messaging.…
Prentice S, Nassanga B, Webb EL, Akello F, Kiwudhu F, et al.
Background Trials done in infants with low birthweight in west Africa suggest that BCG vaccination reduces all-cause mortality in the neonatal period, probably because of heterologous protection against non-tuberculous infections. This study investigated whether BCG alters all-ca…
Stefan Fabian Weber, Rebecca Wolf, Katharina Manten, Balamugesh Thangakunam, Barney Isaac, et al.
… and chest x-ray (CXR). A multivariable model incorporating clinical and ultrasound findings was explored using generalized mixed models and a random forest approach. (Trial registry DRKS00026636). **FINDINGS:** Among 541 participants, 102 (19%) were diagnosed with TB and 1% wer…
Collins Ankunda, Jude Emunyu, Sharon Namasambi, Conrad Sserunjogi, Brendah Kyomuhangi, et al.
…2019–2023). **METHODS:** We conducted a single site registry based study analysing TB patient data from 2019 to 2023, involving 1,051 tuberculosis patients who initiated treatment at Mildmay Uganda Hospital. Descriptive statistics summarized demographics and clinical char…
Patra J, Irving H, Maini P, Liang J, Patra A, et al.
…r approximately a third of pediatric MDR-TB cases globally. Clinical management is challenging; recommendations are based on limited evidence. We assessed the clinical outcomes for children and adolescents treated for XDR-and pre-XDR-TB. We performed a systematic review and meta-…
Crowley JJ, Warren RB, Cather JC
…ata from randomized, placebo- and active-controlled phase 3 clinical trials show tildrakizumab, guselkumab and risankizumab to have a favourable risk-benefit profile in patients with moderate to severe psoriasis. No significant safety concerns have been observed for any of these …
Solans BP, Béranger A, Radtke K, Mohamed A, Mirzayev F, et al.
…les were screened. We searched PubMed, EMBASE, CENTRAL, and trial registries from 2010 to 2021. We included studies in children aged Results Of 304 studies identified, 46 were eligible for full-text review, and 12 and 18 articles were included for the efficacy and PK analyses, re…
Schnippel K, Ndjeka N, Maartens G, Meintjes G, Master I, et al.
…as associated with an increased risk of death in a phase 2b clinical trial, resulting in caution from WHO. Following a compassionate access programme and local regulatory approval, the South African National Tuberculosis Programme began widespread use of bedaquiline in March, 201…