Showing 151–175 of 200 documents
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Alexa Giovanatti, Adrienne E Shapiro
…cine hesitancy following the introduction of novel COVID-19 vaccines. To address this gap, a literature search was conducted for published studies evaluating socio-behavioral predictors of acceptability of HPV, COVID, and childhood immunizations as proxy indicators since there is…
Saleemi MA, Zhang Y, Zhang G
… in vaccine-related research, developing improved and safer vaccines against devastating infectious diseases including Ebola, tuberculosis and acquired immune deficiency syndrome (AIDS) remains a significant challenge. In addition, some of the current human vaccines can cause adv…
Rodo MJ, Rozot V, Nemes E, Dintwe O, Hatherill M, et al.
…e that the antigen-specific immune response induced by such vaccines provides an objective, data-driven basis for prioritisation of vaccine candidates for efficacy testing. We analyzed frequencies of antigen-specific CD4 and CD8 T cells expressing IFNγ, IL-2, TNF and/or IL-17 fro…
Khan H, Bhargava V, Elkins KL
Traditionally, successful vaccines rely on specific adaptive immunity by activating lymphocytes with an attenuated pathogen, or pathogen subunit, to elicit heightened responses upon subsequent exposures. However, recent work with Mycobacterium tuberculosis and other pathogens has…
Ritter K, Behrends J, Erdmann H, Rousseau J, Hölscher A, et al.
…ctive immunity to Mycobacterium tuberculosis (Mtb). Subunit vaccines potently promote protective immune responses against Mtb infection that correlate with an expansion of IL-23-dependent Th17 cells. Previous studies revealed that after vaccination, IL-23 is required for protecti…
Martin SW, O'Keeffe J, Byrne AW, Rosen LE, White PW, et al.
Bovine tuberculosis (BTB) remains as a costly disease of cattle-herds in the Republic of Ireland (ROI). This persistence is partially attributable to the presence of M. bovis infection in a wildlife reservoir, the European badger (Meles meles). Thus, both area-wide and limited-ar…
Clark RA, Mukandavire C, Portnoy A, Weerasuriya CK, Deol A, et al.
…sis is a leading infectious cause of death worldwide. Novel vaccines will be required to reach global targets and reverse setbacks resulting from the COVID-19 pandemic. We estimated the impact of novel tuberculosis vaccines in low-income and middle-income countries (LMICs) in sev…
Perrett S, Lesellier S, Rogers F, Williams GA, Gowtage S, et al.
European badgers (Meles meles) are a wildlife reservoir for Mycobacterium bovis (M. bovis) in parts of England, Wales and Ireland, constituting a potential source of tuberculosis (TB) infection for cattle. Vaccination of badgers against TB is one of the tools available for helpin…
Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, et al.
…each vaccine with placebo. Results Both the BCG and H4:IC31 vaccines were immunogenic. QFT conversion occurred in 44 of 308 participants (14.3%) in the H4:IC31 group and in 41 of 312 participants (13.1%) in the BCG group, as compared with 49 of 310 participants (15.8%) in the pla…
Nayak SS, Sethi G, Ramadas K
Tuberculosis is an airborne transmissible disease caused by Mycobacterium tuberculosis that infects millions of lives worldwide. There is still no single comprehensive therapy or preventative available for the lethal illness. Currently, the available vaccine, BCG is ineffectual i…
Arinaminpathy N, Rade K, Kumar R, Joshi RP, Rao R
…impacts were compared for disease- vs. infection-preventing vaccines, as well as when prioritizing vulnerable groups (those with undernutrition) rather than the general population. A sensitivity analyses were also conducted with respect to the duration, and efficacy, of vaccine i…
Qin L, Sun Y, Gao N, Ling G, Zhang P
Vaccines are the cornerstone of world health. The majority of vaccines are formulated as injectable products, facing the drawbacks of cold chain transportation, needle-stick injuries, and primary systemic immunity. Inhalable vaccines exhibited unique advantages due to their small…
White AD, Sibley L, Sarfas C, Morrison AL, Bewley K, et al.
The tuberculosis vaccine, Bacille Calmette-Guerin (BCG), also affords protection against non-tuberculous diseases attributable to heterologous immune mechanisms such as trained innate immunity, activation of non-conventional T-cells, and cross-reactive adaptive immunity. Aerosol …
Boisson-Walsh A, Thompson P, Fried B, Shea CM, Ngimbi P, et al.
…reduce preventable childhood illness by distributing infant vaccines, immunization coverage in sub-Saharan African settings remains low. Further, timely administration of vaccines at birth-tuberculosis (Bacille Calmette-Guérin [BCG]) and polio (OPV0)-remains inconsistent. As coun…
Smith F, Robertson A, Smith GC, Gill P, McDonald RA, et al.
Vaccination is a useful approach for the control of disease in wildlife populations. However, its effectiveness is dependent in part on delivery to a sufficient proportion of the target population. Measuring the proportions of wild animal populations that have been vaccinated is …
Kimra S James, Neharika Jain, Kelly Witzl, Nico Cicchetti, Sarah M Fortune, et al.
…differences in genetic requirements between live attenuated vaccines and vaccination routes are observed, suggesting that different immunization strategies impose distinct bacterial stressors. Collectively, these data support the idea that Mtb requires genes that enable stress ad…
Harris RC, Sumner T, Knight GM, Zhang H, White RG
More effective tuberculosis vaccines are needed to help reach World Health Organization tuberculosis elimination goals. Insufficient evidence exists on the potential impact of future tuberculosis vaccines with varying characteristics and in different epidemiological settings. To …
Portnoy A, Arcand JL, Clark RA, Weerasuriya CK, Mukandavire C, et al.
…this study, we estimated the impact of introducing novel TB vaccines on gross domestic product (GDP) growth in 105 LMICs. Methods and findings We adapted an existing macroeconomic model to simulate country-level GDP trends between 2020 and 2080, comparing scenarios for introducti…
Jiaqi Chen, Weitong Lin, Chaokai Yang, Wenqi Lin, Xinghui Cheng, et al.
Mucosal vaccines, delivered intranasally or via inhalation, are being studied for respiratory infectious diseases like COVID-19 and influenza. These vaccines aim to provide non-invasive administration and strong immune responses at infection sites, making them a promising area of…
Soundarya JSV, Ranganathan UD, Tripathy SP
… TB vaccine candidate than BCG. There are several alternate vaccines available for TB such as DNA, subunit, adjuvant, and live-attenuated vaccines. Use of auxotrophic vaccine is an emerging technology. Newer vaccine technologies include vaccine delivery methods such as adenovirus…
Ocan M, Katusiime M, Kyabayinze D, Kwesiga B, Ayebare R, et al.
Background Coronavirus disease 2019 (COVID-19) vaccination is crucial for healthcare workers (HCWs) and understanding their perspectives is vital for promoting vaccine uptake in communities. Aim This study assessed factors influencing COVID-19 vaccine uptake among HCWs in Kampala…
Ezie Kengo N, Ghislain FS, Zolo Y, Saidu Musa S, Musa Shallangwa M, et al.
…enuate the impact of the virus, including barrier measures, vaccines and even traditional therapies. The initial promotion of traditional remedies as control measures created a preference over vaccines due to misinformation from social media platforms, contributing to fear of vac…
Schreiner CL, Nuismer SL, Basinski AJ
…to assess the outcomes of vaccination campaigns that deploy vaccines once per annual population cycle.Optimal timing of vaccination is an important consideration in animals with short to intermediate life spans and a short birthing season. Vaccines that are deployed shortly after…
Juste RA, Blanco-Vázquez C, Barral M, Prieto JM, Varela-Castro L, et al.
Badgers ( Meles meles ) are a major tuberculosis (TB) reservoir in Europe, with the potential to transmit infection to cattle. Here we assessed whether a recently described oral tuberculosis vaccine based on heat-inactivated Mycobacterium bovis (HIMB) , delivered as edible baits,…
Zhu B, Dockrell HM, Ottenhoff THM, Evans TG, Zhang Y
…el TB vaccine candidates being developed include whole-cell vaccines (recombinant BCG (rBCG), attenuated Mycobacterium tuberculosis, killed M. tuberculosis or Mycobacterium vaccae), adjuvanted protein subunit vaccines, viral vector-delivered subunit vaccines, plasmid DNA vaccines…