Showing 151–175 of 200 documents
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Daniel Capellán-Martín, Juan J Gómez-Valverde, Ramón Sánchez-Jacob, Alicia Hernanz-Lobo, H Simon Schaaf, et al.
…den, particularly in low-resource, high-prevalence regions. Pediatric TB diagnosis poses challenges with non-specific symptoms and less distinct radiological manifestations than adult TB. Many affected children remain undiagnosed or untreated. The World Health Organization (WHO) …
Xixiong Lin, Xing Zhang, Liping Zhang, Linhu Hui, Zhongjian Su, et al.
**BACKGROUND:** Pediatric myocarditis is an inflammatory disease of the heart with heterogeneous clinical presentations and poorly understood immune mechanisms. T cell receptor (TCR) repertoire profiling provides insights into disease-associated adaptive immune responses. **METH…
Babak Pourakbari, Hani Rostami Rad, Maryam Sotoudeh, Reihaneh Hosseinpour Sadeghi, Shima Mahmoudi, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) remains a significant global health issue due to its diagnostic complexity and paucibacillary nature. This study aimed to evaluate the clinical, diagnostic, and immunological characteristics of pulmonary TB (PTB) and extrapulmonary TB (…
Ness TE, Meiwes L, Kay A, Mejia R, Lange C, et al.
…length, and purity. This same process was performed with 10 pediatric participants diagnosed with pulmonary TB, and the samples underwent tNGS. The FastDNA spin kit for soil showed the best results on model samples spiked with known quantities of BCG, compared to the other extrac…
Bedir Demirdag T, Ozkaya Parlakay A, Aydin F, Tugcu GD, Santaflıoglu B, et al.
… who received different biologic modifying therapies in our pediatric rheumatology department and the possibility of development of tuberculosis (TB). Methodology This retrospective study was conducted in Ankara City Hospital. Pediatric patients who were treated with biologic mod…
He Y, Lyon CJ, Nguyen DT, Liu C, Sha W, et al.
Diagnosis of pediatric tuberculosis (TB) is often complicated by its nonspecific symptoms, paucibacillary nature, and the need for invasive specimen collection techniques. However, a recently reported assay that detects Mycobacterium tuberculosis virulence factors in serum can di…
Nadig ND, Rajan P, Kolahalam VSK, Peddi S, Rathi T, et al.
…rom one month to 18 years. Methodology At the Department of Pediatrics, a 12-month prospective observational research involving 70 pediatric patients with pancytopenia was carried out. Documentation included demographic information, clinical manifestations, history of vaccination…
Waqar Ahmed, Israr Ahmed, Fareeda Bhanbhro, Asghar Kerio, Arbab Ali, et al.
**BACKGROUND:** Pediatric HIV remains a significant public health concern, particularly in resource-limited settings such as Pakistan. Early diagnosis and intervention are essential for improving outcomes. This study aimed to determine the frequency of pediatric HIV infections am…
Oana Mariana Mihailov, Loredana Stavăr Matei, George Țocu, Valerii Luțenco, Cosmin George Popovici, et al.
…valuate the pattern and evolution of depressive symptoms in pediatric TB patients during treatment using a structured screening approach. **METHODS:** We conducted a retrospective observational study including 190 pediatric patients aged 7-18 years diagnosed with tuberculosis be…
Zhou H, Pei Y, Xie Q, Nie W, Liu X, et al.
… samples. Methods A total of 64 participants, comprising 43 pediatric PTB and 21 pediatric pneumonia patients were recruited in the present study. BALF samples were collected from the above participants. Parallel comparisons between mNGS and conventional microbial test (CMT) path…
Lyu C, Shi H, Cui Y, Li M, Yan Z, et al.
Pediatric tuberculosis (TB) is an important part of global TB prevention and control. Diagnosis of childhood TB still remains challenging when using conventional tests, due to the non-specific clinical manifestations and paucibacillary nature of the specimens. Thus, a sensitive, …
Hamdar H, Nahle AA, Ataya J, Jawad A, Salame H, et al.
…ristics, diagnostic methods, and early mortality rate among pediatric patients with pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) who were admitted to a hospital in Syria. This retrospective cohort study was conducted at the University Children's Hospital in…
Ndakidemi E, Emerson C, Medley A, Ngowi B, Ng'eno B, et al.
…ion and treatment, as well as linkage of TB and HIV care in pediatric patients. METHODS: In-depth interviews were conducted in March 2016 at 10 high TB burden clinics in five districts of Tanzania to identify the barriers to pediatric TB diagnosis and HIV care. Health care worker…
Vasanthakumar Manokaran, Baljinder Kaur, Jane Allen Christa A, Reshma I
…ains a significant global health challenge, particularly in pediatric populations, where effective treatment with anti-tubercular therapy (ATT) is often complicated by adverse drug reactions. Drug-induced liver injury (DILI) is among the most serious complications of ATT, and ide…
Johari M, Sharma R, Bagri DR, Malhotra B
…en this study to evaluate the diagnostic value of CBNAAT in pediatric tuberculosis in comparison to other methods like microscopic detection of acid-fast bacilli and detection of mycobacteria-by-mycobacteria growth indicator tube (MGIT). Material and methods This hospital-based, …
Denoeud-Ndam L, Otieno-Masaba R, Tchounga B, Machekano R, Simo L, et al.
…ategies will be compared: i) The standard of care, offering pediatric TB services based on national standard of care; ii) The intervention, with pediatric TB services integrated into child healthcare services: it consists of a package of training, supportive supervision, job aids…
Mustafa G, Almarshad F
… countries. This study focuses on the burden and pattern of pediatric and adolescent MDR-TB in a tertiary care hospital setting. Aims/objectives The main objective is to evaluate MDR-TB's prevalence and resistance patterns among pediatric and adolescent patients, highlighting cri…
Drobish I, Ramchandar N, Raabe V, Pong A, Bradley J, et al.
…ted for MTB complex OAI over a 26-year period at a tertiary pediatric center in southern California. Methods We conducted a retrospective review of children diagnosed with MTB complex OAI and cared for between 31 Dec 1992 to 31 Dec 2018 at a single tertiary care pediatric hospita…
Battaglia CSP, Parente AAAI, Luiz RR, Aurilio RB, Pinheiro MAS, et al.
…s To evaluate the contribution of Ultra to the diagnosis of pediatric pulmonary tuberculosis (PTB). Methods We analyzed prospective data from children and adolescents with presumed PTB whose specimens were tested with Ultra between January 2020 and December 2022. Diagnosis was ba…
Katherine Turnbull, Eunice Vincent, Huanbin Xu, Peter J Didier, Robert V Blair, et al.
Clinically relevant pediatric animal models are required to advance research and therapies for() infections in children. Utilizing infant rhesus macaques exposed to controlled doses of aerosolizedCDC1551, we systematically monitored physical changes and assessed signs of tubercul…
Nadege Nziza, Wonyeong Jung, Tina Chen, Yixiang Deng, Kees L M C Franken, et al.
… to severe forms of the disease. However, whether different pediatric outcomes relate to distinct immunologic responses remains incompletely understood. Emerging data suggest that Mtb-specific humoral immune responses represent a correlate of protection against Mtb both following…
Guthrie JL, Delli Pizzi A, Roth D, Kong C, Jorgensen D, et al.
…n. Genotyping and whole-genome sequencing (WGS) can enhance pediatric TB investigations by confirming or refuting transmission events. Methods Mycobacterium tuberculosis isolates from all pediatric patients Results Twenty-three children were Canadian-born, 7 to Canadian-born pare…
Hunter OF, Kyesi F, Ahluwalia AK, Daffé ZN, Munseri P, et al.
…llenging. We assessed IPT implementation and adherence at a pediatric HIV clinic in Tanzania. Methods In this prospective cohort study, eligible children living with HIV aged 1-15 years receiving care at the DarDar Pediatric Program in Dar es Salaam who screened negative for TB d…
Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi TK, Tlhakanelo JT, et al.
…duction Globally, the amount of research on the outcomes of pediatric tuberculosis (TB) is disproportionately less than that of adult TB. The diagnosis of paediatric TB is also problematic in developing countries. The aim of this study was to describe the outcomes of pediatric TB…
Yuanxi Zou, Jerry Nedelman, Mats O Karlsson, Elin M Svensson
**BACKGROUND AND OBJECTIVE:** In pediatric trial design, it is particularly essential to maximize data utilization and ensure robust designs while minimizing sample collection. A common criterion to justify pediatric pharmacokinetic study designs is based on parameter precision (…