Showing 151–175 of 200 documents
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Skouras VS, Kalomenidis I
…g categories, detection methods, prevalence and patterns of drug resistance among patients with tuberculous pleural effusion (TPE) and to comment on the management of suspected drug-resistant TPE. Recent findings Pleural and pulmonary tuberculosis (TB) present similar patterns of…
Giri VP, Giri OP, Pandey PT, Mishra KN, Prasad RS, et al.
Background Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug re…
Mvelase NR, Balakrishna Y, Lutchminarain K, Mlisana K
Objectives South Africa ranks among the highest drug-resistant tuberculosis (DR-TB) burdened countries in the world. This study assessed the changes in resistance levels in culture confirmed Mycobacterium tuberculosis (MTB) in the highest burdened province of South Africa during …
Stone H, Duggal M, Sacks L, Ghosh M
Abstract Background Multi and extensively drug-resistant (MDR and XDR) tuberculosis (TB) remains a treatment challenge due to drug adverse events (AEs) and long regimens. Our aim was to identify AEs which resulted from repurposing drugs for MDR and XDR-TB. Methods A PubMed search…
Li S, Chen W, Feng M, Liu Y, Wang F
…by the disease have been decreasing. However, the number of drug-resistant tuberculosis patients is increasing rapidly year by year. Here, a total of 380 Mycobacterium tuberculosis (MTB)-positive formalin-fixed and paraffin-embedded tissue (FFPE) specimens diagnosed in the Depart…
Gygli SM, Keller PM, Ballif M, Blöchliger N, Hömke R, et al.
Whole-genome sequencing allows rapid detection of drug-resistant Mycobacterium tuberculosis isolates. However, the availability of high-quality data linking quantitative phenotypic drug susceptibility testing (DST) and genomic data have thus far been limited. We determined drug r…
Hui Cen, Peng Zhang, Yunchao Ling, Guoping Zhao, Guoqing Zhang
Understanding the mechanisms of drug resistance in(MTB) is essential for the rapid detection of resistance and for guiding effective treatment, ultimately contributing to reducing the global burden of tuberculosis (TB). Under anti-TB drugs pressure, MTB continues to accumulate re…
Bui VCB, Yaniv Z, Harris M, Yang F, Kantipudi K, et al.
Tuberculosis (TB) drug resistance is a worldwide public health problem. It decreases the likelihood of a positive outcome for the individual patient and increases the likelihood of disease spread. Therefore, early detection of TB drug resistance is crucial for improving outcomes …
Okumu Albert, Odeny Lazarus, Ochieng John Benjamin, Odhiambo Ben, Sitati Ruth, et al.
…treatment. Molecular techniques enable characterization and drug resistance profiling, this study sought to determine NTM prevalence, circulating species, and distribution factors among presumptive multidrug-resistant tuberculosis (MDR-TB) patients in western Kenya. **METHOD:** …
Gupta-Wright A, Fielding K, van Oosterhout JJ, Alufandika M, Grint DJ, et al.
…ak routine virological monitoring has driven increasing HIV drug resistance. We investigated ART failure, drug resistance, and early mortality among patients with HIV admitted to hospital in Malawi. Methods This observational cohort study was nested within the rapid urine-based s…
Ismail N, Ismail F, Omar SV, Blows L, Gardee Y, et al.
…nization End TB Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. Objective We sought to review the current status of drug resistant tuberculosis in Africa and highlight key area…
Truden S, Sodja E, Žolnir-Dovč M
…cterium tuberculosis (MT) complex with mutations conferring resistance to isoniazid (INH), ethionamide (ETH), fluoroquinolone (FQ), and second-line injectable drugs (SLIDs). The aim of our study was to evaluate the performance of the Xpert MTB/XDR rapid molecular assay on rifampi…
Schnippel K, Ndjeka N, Maartens G, Meintjes G, Master I, et al.
Background Addition of bedaquiline to treatment for multidrug-resistant tuberculosis was associated with an increased risk of death in a phase 2b clinical trial, resulting in caution from WHO. Following a compassionate access programme and local regulatory approval, the South Afr…
Wu Q, Wang M, Zhang Y, Wang W, Ye TF, et al.
…cerns, while the comprehensive evaluations of DM status and drug resistance in TB patients are still lacking. Methods All details of TB cases were collected from drug resistance monitoring sentinels in Zhejiang province. Fisher's exact test or Pearson chi-square test (χ 2 ) was u…
Li X, Sheng L, Tu J, Lou L
…he bactericidal effect of nano silver and anti-tuberculosis drugs on drug-resistant Mycobacterium tuberculosis . Solid-state drug sensitivity tests with streptomycin (SM), isoniazid (INH), RIF, EMB, kanamycin (km), and ofloxacin (ofx) were carried out on H37Rv and different clini…
Fang WJ, Tang SN, Liang RY, Zheng QT, Yao DQ, et al.
…he two most promising imaging signs in differentiating multidrug-resistant (MDR)-pulmonary tuberculosis (PTB) from drug-sensitive (DS)-PTB. However, there have been concerns that literature described radiological feature differences between DS-PTB and MDR-PTB were confounded by t…
Jiang F, Xu C, Wang Y, Xu Q
…tomography based radiomics in the differential diagnosis of drug-sensitive and drug-resistant pulmonary tuberculosis. Methods The clinical and computed tomography image data of 177 patients who were diagnosed with pulmonary tuberculosis through sputum culture and completed drug-s…
K SP, Parivakkam Mani A, S G, Yadav S
…bal health concern, particularly with the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). Traditional methods for diagnosing drug resistance in TB are time-consuming and often lack accuracy, leading to delays in appropr…
Wang Y, Xu H, Li Y, Gao H, Zhang Z, et al.
Drug-resistant tuberculosis (DR-TB), particularly multidrug-resistant tuberculosis (MDR-TB), has been identified as a major challenge for effective TB control. For rapid detection and proper treatment, molecular assays based on the identification of mutations in genes associated …
Ankita Pal, Sapna Pal, Shweta Mahapatra, Apratim Pandey, Debasisa Mohanty
…d on the statistical significance of their association with resistance or susceptibility to various drugs. However, the mechanism by which they confer resistance to drugs is often not understood. To address these gaps, we combined known resistance associated mutations from the WH…
Sylverken AA, Kwarteng A, Twumasi-Ankrah S, Owusu M, Arthur RA, et al.
Resistance to Tuberculosis drugs has become a major threat to the control of tuberculosis (TB) globally. We conducted the first nation-wide drug resistance survey to investigate the level and pattern of resistance to first-line TB drugs among newly and previously treated sputum s…
Lin M, Zhong Y, Chen Z, Lin C, Pei H, et al.
Objectives To assess the proportion of drug-resistant tuberculosis (TB) cases and to identify independent risk factors associated with drug-resistant TB in Hainan. Methods Descriptive analysis of demographic and clinical data of culture-positive TB patients to assess the trends i…
Dan Qiu, JianHong Ma, ZhiFang Liu, XiangXing Zeng
…ntified as a high-burden country. Data on the prevalence of drug resistance is crucial for informing the selection of appropriate pharmacological interventions for the treatment of drug-resistant tuberculosis (DR-TB).To evaluate the prevalence and drug resistance patterns among p…
Colman RE, Seifert M, De la Rossa A, Georghiou SB, Hoogland C, et al.
Background Drug-resistant tuberculosis remains a major obstacle in ending the global tuberculosis epidemic. Deployment of molecular tools for comprehensive drug resistance profiling is imperative for successful detection and characterisation of tuberculosis drug resistance. We ai…
Jinyun Zhao, Weifang Mao, Faxiang Jin, Wenfang Xu
**OBJECTIVE:** This study aimed to analyze drug resistance patterns, mutation profiles inisolates and clinical characteristics of tuberculosis patients in Shaoxing, Zhejiang, China. **METHODS:** Clinical specimens and data from tuberculosis patients admitted in 2024 were collect…