Showing 126–150 of 200 documents
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Katale BZ, Mbelele PM, Mbelele PM, Lema NA, Campino S, et al.
Background Tuberculosis (TB), particularly multi- and or extensive drug resistant TB, is still a global medical emergency. Whole genome sequencing (WGS) is a current alternative to the WHO-approved probe-based methods for TB diagnosis and detection of drug resistance, genetic div…
Castro-Rodríguez B, Cazar-Ramos C, Franco-Sotomayor G, Cardenas-Franco GE, Orlando SA, et al.
Latin American region is a high-burden setting for tuberculosis where multidrug-resistant tuberculosis (MDR-TB) is among the main challenge to move forward the End TB Strategy goals. It has been shown that MDR-TB is associated to certain Mycobacterium tuberculosis (MTB) lineages …
Wang P, Gu J, Yang J, Yang C, Wu X, et al.
Background Re-treatment pulmonary tuberculosis (PTB) has a high risk of being multi-drug- or rifampicin-resistant tuberculosis (MDR/RR-TB). The Xpert MTB/RIF assay possesses high efficacy for the evaluation of rifampicin resistance. The aim of the present study was to assess the …
Shulin Song, Donghui Gan, Di Wu, Ting Li, Shiqian Zhang, et al.
The issue of multi-drug-resistant tuberculosis (MDR-TB) presents a substantial challenge to global public health. Regrettably, the diagnosis of drug-resistant tuberculosis (DR-TB) frequently necessitates an extended period or more extensive laboratory resources. The swift identif…
Takii T, Seki K, Wakabayashi Y, Morishige Y, Sekizuka T, et al.
We investigated the lineages of Mycobacterium tuberculosis (Mtb) isolates from the RYOKEN study in Japan in 2007 and the usefulness of genotypic drug susceptibility testing (DST) using the Genome Research for Asian Tuberculosis (GReAT) database. In total, 667 isolates were classi…
Mehta V, Desai D, Abraham P, Gupta T, Rodrigues C, et al.
Background Isolation of Mycobacterium tuberculosis on culture is vital for differentiating intestinal tuberculosis (ITB) from Crohn's disease (when histology is not diagnostic) and for diagnosis of multidrug-resistant tuberculosis. The current yield of TB culture ( Aim To determi…
Mesfin EA, Merker M, Beyene D, Tesfaye A, Shuaib YA, et al.
Background Ethiopia is one of the high multidrug-resistant tuberculosis (MDR-TB) burden countries. However, phenotypic drug susceptibility testing can take several weeks due to the slow growth of Mycobacterium tuberculosis complex (MTBC) strains. In this study, we assessed the pe…
Akalu TY, Clements ACA, Gebreyohannes EA, Gilmour B, Alene KA
Introduction Contact investigations with drug-susceptible tuberculosis (DS-TB) patients have demonstrated a high prevalence of tuberculosis infection (TBI). However, the prevalence of TBI among individuals in close contact with drug-resistant tuberculosis (DR-TB) patients is poor…
Chen Q, Huang T, Zou L, Tang X, Shi Z, et al.
The treatment of multidrug-resistant tracheobronchial tuberculosis poses challenges, and research investigating the efficacy of bedaquiline or delamanid as treatment for this condition is limited. This retrospective cohort study was conducted from 2017 to 2021. The study extracte…
Okumu A, Orwa J, Sitati R, Omondi I, Odhiambo B, et al.
Multidrug-resistant tuberculosis (MDR-TB) is caused by M. tuberculosis ( Mtb ) with resistance to the first-line anti-TB medicines isoniazid (INH) and rifampicin (RIF). In Western Kenya, there is reported low prevalence of drug resistant strains among HIV tuberculosis patients, c…
Shin HS, Choi DS, Na JB, Choi HY, Kim JE, et al.
…ound The loss of muscle mass in primary multidrug-resistant tuberculosis (MDR-TB) has not been examined in previous studies. This study aimed to investigate that low pectoralis muscle index and characteristic CT features can help differentiate patients with primary MDR-TB from th…
Choi H, Jeong D, Kang YA, Jeon D, Kang HY, et al.
… treatment of fluoroquinolone-resistant multidrug-resistant tuberculosis (FQr-MDR-TB) is difficult because of the limited number of available core anti-TB drugs and high rates of resistance to anti-TB drugs other than FQs. However, few studies have examined anti-TB drugs that are…
Desissa F, Workineh T, Beyene T
Background Multidrug-resistant tuberculosis (MDR-TB) is resistant to the two main first-line anti-tuberculosis drugs: rifampicin and isoniazid. It is a major threat to public health worldwide. The objective of this study was to assess the potential risk factors for multidrug-resi…
Zhang Y, Zhao R, Zhang Z, Liu Q, Zhang A, et al.
Objective Pediatric tuberculosis (TB) is one of the top ten causes of death in children. Our study was to analyze influencing factors of multidrug-resistant tuberculosis (MDR-TB) and validation of whole-genome sequencing (WGS) used in children with drug-resistant TB (DR-TB). Meth…
Ma J, Liu H, Wang J, Li W, Fan L, et al.
… global burden of rifampicin resistance/multidrug-resistant tuberculosis (RR/MDR-TB) and low HIV incidence. Our aim was to assess the clinical and demographic characteristics of RR/MDR-extrapulmonary tuberculosis (EPTB) from 2015 to 2019 to provide evidence for the prevention and…
Aytenew Atnaf, Mekuanenit Kibret, Bekele Tesfaye, Desalegn Abebaw
**BACKGROUND:** The emergence of multidrug-resistant tuberculosis (MDR-TB) is a threat to the people of resource-limited countries, such as Ethiopia. This study aimed to assess the magnitude, predictors and trends of multidrug-resistant tuberculosis among patients with pulmonary …
Khan HA, Devi U, Iqbal MF, Aamir A
…pothyroidism, once considered a rare adverse effect of anti-tuberculosis (TB) medication, is increasingly observed in patients undergoing second-line therapy for multidrug-resistant tuberculosis (MDR-TB). This study discusses a case involving a 17-year-old female patient who pres…
Dilyara Esmedlyaeva, Igor Mokrousov, Nina Alekseeva, Natalia Blum, Marina Dyakova, et al.
…es in the renal parenchyma during the pathogenesis of renal tuberculosis in a rabbit model. **METHODS:** Renal tuberculosis was modeled on 60 male Soviet Chinchilla rabbits. The susceptible virulent strainH37Rv (Euro-American lineage, group 1) and the low-lethal multidrug-resist…
…including the WHO Consolidated Guidelines on Drug Resistant Tuberculosis Treatment, issued by WHO in March 2019. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups, using the GRADE (Grading of Recommendations, A…
Nazanin Ahmad Khosravi, Azar Dokht Khosravi, Mohammad Hashemzadeh, Mohammad Savari, Morteza Saki
…sistance rates and related gene mutations in MDRin regional tuberculosis reference laboratories of Iran. **METHODS:** In this cross-sectional study, MDRisolates (resistant to antibiotics rifampicin and isoniazid) were collected from sputum samples of tuberculosis patients referr…
Haile B, Tafess K, Zewude A, Yenew B, Siu G, et al.
Tuberculosis (TB) is one of the leading causes of morbidity and mortality in different zones of Ethiopia. This study was undertaken to identify the strains of Mycobacterium tuberculosis and evaluate their drug sensitivity profiles in the Arsi Zone. A total of 111 isolates of M. t…
Ashwin Karnan, Ulhas Jadhav, Babaji Ghewade, Vivek Alone
**UNLABELLED:** Multidrug-resistant tuberculosis is a major public health concern with prolonged infectivity, a complex treatment regimen, and lower treatment success rates. Despite the significant progress made by India in the control of Tuberculosis, it remains the second leadi…
Shulin Song, Song Chen, Canling Chen, Donghui Gan, Di Wu, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) poses an escalating public health challenge that complicates diagnosis and treatment. Early detection is crucial for improving the outcomes. This study aimed to evaluate the diagnostic performance of whole-lung computed to…
Zong Z, Huo F, Shi J, Jing W, Ma Y, et al.
Tuberculosis (TB) recurrence can result from either relapse of an original infection or exogenous reinfection with a new strain of Mycobacterium tuberculosis (MTB). The aim of this study was to assess the roles of relapse and reinfection among recurrent TB cases characterized by …
Weldemhret L
Early and rapid diagnosis of Mycobacterium tuberculosis in clinical specimen is important for the treatment of patients and control of disease transmission to the community. The disease is largely preventable and curable, but without rapid, and correct diagnostic tools for tuberc…