Showing 126–150 of 200 documents
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Shi SD, Hsueh PR, Yang PC, Chou CC
As more than two billion people possibly have a latent tuberculosis (LTB) infection, early LTB diagnosis is crucial for the efficient control and elimination of tuberculosis (TB). The aim of this study is to detect the serum antibody responses to dormancy-related DosR regulon ant…
Wang X, Jiang K, Xing W, Xin Q, Hu Q, et al.
Background Distinguishing between active tuberculosis disease (TBD) and latent tuberculosis infection (TBI) is crucial for TB control but remains challenging. Methods Single-cell RNA sequencing was conducted on purified Mycobacterium tuberculosis (MTB)-specific CD154 + CD4 + T ce…
Khayumbi J, Sasser LE, McLaughlin TA, Ongalo J, Tonui J, et al.
…ted with dysregulated CD4 T cell responses to Mycobacterium tuberculosis (Mtb) and increased risk of developing tuberculosis. Mtb-specific CD4 T cells in people with HIV have diminished Th1 cytokine production capacity, thus we utilized a flow cytometry-based assay to measure CD4…
Wang C, Hua J, He X, Chen L, Lv S
…y-related genes (ARGs) in the blood to differentiate active tuberculosis (ATB) and latent tuberculosis infection (LTBI). Design Secondary data analysis of three prospective cohorts. Methods The expression of ARGs in patients with ATB and LTBI were analyzed using the GSE37250, GSE…
Kaul S, Nair V, Birla S, Dhawan S, Rathore S, et al.
Diagnosis of latent tuberculosis infection (LTBI) using biomarkers in order to identify the risk of progressing to active TB and therefore predicting a preventive therapy has been the main bottleneck in eradication of tuberculosis. We compared two assays for the diagnosis of LTBI…
Soe PT, Hanthamrongwit J, Saelee C, Kyaw SP, Khaenam P, et al.
…cy-associated antigens Rv2659c and Rv3128c of Mycobacterium tuberculosis by examining the persistence of specific IgG and IgA memory B cells (MBCs) among patients with active tuberculosis (TB), household contacts with latent tuberculosis (LTBI), and an endemic healthy control gro…
Soriano-Arandes A, Caylà JA, Gonçalves AQ, Orcau À, Noguera-Julian A, et al.
Introduction Tuberculosis (TB) is a global infectious disease. In low-incidence countries, paediatric TB affects mostly immigrant children and children of immigrants. We hypothesize that these children are at risk of exposure to Mycobacterium tuberculosis when they travel to the …
Zhu P, Hao X, Wang W, Wang W, Xu B, et al.
…ckground The influencing factors of the process from latent tuberculosis infection (LTBI) to the onset of active tuberculosis (TB) remain unknown among different population groups, especially among older individuals in high-incidence areas. This study aimed to investigate the dev…
König Walles J, Tesfaye F, Jansson M, Tolera Balcha T, Winqvist N, et al.
…N-TB Gold Plus (QFT-Plus), which includes two Mycobacterium tuberculosis antigen formulations (TB1 and TB2), for detection of latent tuberculosis infection during pregnancy. Eight-hundred-twenty-nine Ethiopian pregnant women (5.9% HIV-positive) were tested with QFT-Plus, with bac…
Gao X, Wu C, Wang X, Xu H, Wu Y, et al.
… potential risk factors for activating latent Mycobacterium tuberculosis infection. In this study, we evaluated the immune function of Rv1737c, which is a latency-associated antigen of dormancy survival regulator (DosR) of M. tuberculosis in a mouse model. Our data showed that mi…
Zellweger JP, Sotgiu G, Corradi M, Durando P
Introduction Despite great efforts, tuberculosis (TB) is still a major public health threat worldwide. For decades, TB control programs have focused almost exclusively on infectious TB active cases. However, it is evident that this strategy alone cannot achieve TB elimination. To…
Wang W, Chen X, Chen S, Zhang M, Wang W, et al.
Diagnosis and treatment of latent tuberculosis infection (LTBI) is critical to tuberculosis (TB) control. Identifying the risk factors associated with LTBI can contribute to developing an optimized strategy for LTBI management. We conducted a survey of adults aged 65 years and ol…
Chen H, Zhang H, Cheng J, Sun D, Wang Q, et al.
Objectives This study examined adherence rates to tuberculosis preventive treatment (TPT) among close contacts of individuals with pulmonary tuberculosis (PTB) and identified factors associated with TPT adherence in China. Methods A multicenter, cluster-randomized, open-label con…
Cui Z, Lin D, Chongsuvivatwong V, Graviss EA, Chaiprasert A, et al.
…: (1) compare sociodemographic characteristics among active tuberculosis (TB) cases and their household contacts in cold and hot spot transmission areas, and (2) quantify the influence of locality, genotype and potential determinants on the rates of latent tuberculosis infection …
Munisankar S, Rajamanickam A, Balasubramanian S, Muthusamy S, Menon PA, et al.
The prevalence of proximate risk factors for active tuberculosis (TB) in areas of high prevalence of latent tuberculosis infection (LTBI) is not clearly understood. We aimed at assessing the prevalence of non-communicable multi-morbidity focusing on diabetes mellitus (DM), malnut…
Hu Y, Wu Z, Yang X, Ding J, Wang Q, et al.
… (UC) development. This study explores the impact of latent tuberculosis infection (LTBI) on the gut microbiota in UC and assesses changes during vedolizumab treatment, investigating prophylactic anti-tuberculosis therapy. Results This cohort study included adult patients with UC…
Jia J, Chen D, Liu L, Siddiqui MJ, Yang F, et al.
Background China has a high burden of tuberculosis and latent tuberculosis infection (LTBI). The aim of this study was to estimate the prevalence of LTBI among healthy young children and adolescents and test a 2-step approach to explore the threshold for the diagnosis of tubercul…
Kawatsu L, Uchimura K, Ohkado A
Background Screening for latent tuberculosis infection (LTBI) among migrant population has become a critical issue for many low tuberculosis (TB) burden countries. Evidence regarding effectiveness of LTBI programs are limited, however, partly because of paucity of national data o…
Zhang M, Shen L, Zhou X, Chen H
An in-depth understanding of the lung microbiota in tuberculosis (TB) infection could provide optimal strategies for the prophylaxis, diagnosis, and treatment of the disease. Only a few studies have investigated the impact of Mycobacterium tuberculosis (Mtb) infection and anti-TB…
Abbasnia S, Hashem Asnaashari AM, Sharebiani H, Soleimanpour S, Mosavat A, et al.
…tive infections, oncogenes, or chemical agents. The case of tuberculosis (TB) is an outcome of Mycobacterium tuberculosis ( M.tb ) and host interaction in the manifestation of active and latent TB or clearance. This comprehensive review explains and interprets the epigenetics fin…
Hung-Ling Huang, Meng-Hsuan Cheng, Meng-Rui Lee, Jung-Yien Chien, Po-Liang Lu, et al.
…ulmonary disease (COPD) and aging both increase the risk of tuberculosis (TB), an important infectious disease in human. Exploring the burden and predictors of latent tuberculosis infection (LTBI) and treatment outcomes for older individuals with COPD is essential to guide LTBI i…
Deng J, Liu L, Yang Q, Wei C, Zhang H, et al.
Tuberculosis (TB) is a serious infectious disease with high infection and mortality rates. 5%-10% of the latent tuberculosis infections (LTBI) are likely to develop into active TB, and there are currently no clinical biomarkers that can distinguish between LTBI, active TB and oth…
Manoharan A, Siti Nur Farhana H, Manimaran K, Khoo EM, Koh WM
Background Various factors influence tuberculosis preventive treatment (TPT) decisions thus it is important to understand the health beliefs and concerns of patients before starting TPT to ensure treatment compliance. This study aims to explore facilitators and barriers for TPT a…
Zhang Z, Wang Y, Zhang Y, Geng S, Wu H, et al.
Background Tuberculosis (TB) is one of the most infectious diseases caused by Mycobacterium tuberculosis ( M. tb ), and the diagnosis of active tuberculosis (TB) and latent TB infection (LTBI) remains challenging. Methods Gene expression files were downloaded from the GEO databas…
Ruiz-Tagle C, Naves R, García P, Günther A, Schneiderhan-Marra N, et al.
…ny respiratory and enteric infections; however, its role in tuberculosis pathogenesis has been scarcely explored. We aimed to investigate Mycobacterium tuberculosis (Mtb) specific IgA levels in saliva in different stages of latent Tuberculosis Infection (TBI). Methodology A multi…