Showing 126–150 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Lauren R Brown, Mariette Smith, Cari van Schalkwyk, Leigh F Johnson, Vanessa Mudaly, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) remains a major public health concern in high-burden settings like the Western Cape (WC), South Africa. We analyzed geographic differences in TB burden among children and young adolescents, described temporal trends, and quantified gaps…
Li G, Cannon K, Sisniega C, Fergie J
Pediatric tuberculous meningitis (TBM) is a severe form of tuberculosis that may present in children. The current diagnostic methods may have a limited impact on initial clinical decision-making. We present three children with tuberculous meningitis who had Mycobacterium tubercul…
Nadege Nziza, Wonyeong Jung, Tina Chen, Yixiang Deng, Kees L M C Franken, et al.
**BACKGROUND:** Tuberculosis (TB), caused by(Mtb), is among the leading causes of death from an infectious agent among children worldwide. Children represent a particularly vulnerable population due to the greater challenges in diagnosis and the higher risk of progression to seve…
Smiles S, Stante C, Ruda M, Magnanelli V, Palmieri FI, et al.
Tuberculosis is an infectious disease which most commonly compromises the respiratory system, whereas abdominal involvement is rare, thus its diagnosis is a challenge. The clinical manifestations of abdominal tuberculosis as well as its physical examination findings are usually n…
Lahlou C, Faraj C, Essetti S, Hsain IH, Allali N, et al.
Pediatric neuro-meningeal tuberculosis leads to high rates of mortality and morbidity. Prompt diagnosis and initiation of treatment are challenging; imaging findings play a key role in establishing the presumptive diagnosis. General brain imaging findings are well reported; howev…
…ackground Understanding barriers and facilitators to latent tuberculosis infection (LTBI) diagnosis and care is needed to successfully treat children/adolescents with LTBI in the US. We explored physicians’ perspectives on pediatric LTBI diagnosis and care, and strategies to impr…
Sarin S, Huddart S, Raizada N, Parija D, Kalra A, et al.
…tion efforts for up front Xpert MTB/RIF (Xpert) testing for pediatric presumptive tuberculosis (TB) patients in four major Indian cities. Methods Xpert test costs were assessed as weighted average per-test costs based on the daily workload dynamics matched by test volume specific…
Rangchaikul P, Ahn P, Nguyen M, Zhong V, Venketaraman V
In 2014, the World Health Organization developed the End Tuberculosis Strategy with the goal of a 95% reduction in deaths from tuberculosis (TB) by 2035. The start of the COVID-19 pandemic and global lockdown has had a major impact on TB awareness, screening, diagnosis, and promp…
Mihailov OM, Stavar Matei L, Tocu G, Ciubara A, Mihailov R
Background Tuberculosis (TB) is one of the oldest and most persistent infectious diseases, continuing to pose a significant public health challenge worldwide. Children diagnosed with TB are particularly vulnerable to developing depressive disorders, which can significantly reduce…
Karaman ZF
Objective Tuberculosis (TB) is still a global health concern. Although thoracic TB is the most common manifestation, TB can also affect extrathoracic sites, including the central nervous system, musculoskeletal system, and abdomen. The incidence of extrathoracic TB in children is…
Jian Zeng, Haitao Su, Jin Wang, Jiaohong Zhang, Shuihua Lu, et al.
…nvestigate the clinical features and prognostic outcomes of pediatric tuberculosis (TB) in Shenzhen. **METHODS:** This retrospective study collected demographic, clinical, laboratory, and prognostic data from pediatric patients diagnosed with TB between January 2013 and January …
Derese D, Teklu T, Kumalo A, Chinasho T, Anjulo T
Background Tuberculosis (TB) is one of the leading public health problems in children mainly due to difficulties in the diagnosis of disease in children. It has been reported that the commercial urine lipoarabinomannan (LAM) assays used in patients with confirmed pulmonary TB hav…
Shakoor S, Mir F
Childhood tuberculosis (TB) has been underreported and underrepresented in TB statistics across the globe. Contributing factors include health system barriers, diagnostic barriers, and community barriers leading to an underdetected epidemic of childhood tuberculosis. Despite cons…
González Saldaña N, Macías Parra M, Xochihua Díaz L, Palavicini Rueda M, Carmona Vargas AJ, et al.
…tic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if the diagnosis of OATB in pediatrics is a challenge due to its insidious clinical presentation. Methods A retrospective, descriptive study of th…
Hamdar H, Nahle AA, Ataya J, Jawad A, Salame H, et al.
Tuberculosis (TB) is a global public health challenge, contributing significantly to morbidity and mortality worldwide. This research aims to investigate the epidemiology, clinical characteristics, diagnostic methods, and early mortality rate among pediatric patients with pulmona…
Ndzi EN, Nkenfou CN, Mekue LM, Zentilin L, Tamgue O, et al.
The diagnosis of tuberculosis (TB) continues to pose substantial public health problems. The quest for diagnostic biomarkers for TB is therefore primordial. This study aimed to evaluate the diagnostic and anti-TB treatment monitoring potentials of some selected miRNAs. Quantitati…
Shah I, Gandhi DN, Mamtora D, Dey M, Jain S, et al.
Background Microbiological diagnosis of pediatric pulmonary and intestinal tuberculosis remains difficult due to difficulty in specimen collection such as with sputum, gastric aspirates or intestinal biopsies. Stool Xpert MTB/Rif may be useful as specimen collection is non-invasi…
Francesca W Basile, Rodrigo Calderón-Flores, Franziska Held, Luisa Pollmeier, Emmanuel Nasinghe, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of morbidity and mortality in young children, particularly in settings with limited diagnostic capacity. Oral swabs represent a promising alternative specimen type due to their ease of collection, but evidence on their acc…
Yaqoob A, Hinderaker SG, Fatima R, Shewade HD, Nisar N, et al.
Background The National Tuberculosis Control Program (NTP) in Pakistan developed, with the Pakistan Paediatric Association, a pediatric scoring chart to aid diagnosis of childhood tuberculosis (TB). Our study compared the diagnostic practice of private healthcare providers in Pak…
Hamdar H, Nahle AA, Ataya J, Jawad A, Salame H, et al.
Background Tuberculosis (TB) is a global public health challenge, contributing significantly to morbidity and mortality worldwide. This research aims to investigate the epidemiology, clinical characteristics, diagnostic methods, and early mortality rate among pediatric patients w…
Nordholm AC, Holden IK, Hartling UB, Andersen PH, Lillbaek T, et al.
Background In Western Europe, most pediatric tuberculosis (TB) cases occur among immigrants; however, data are rarely stratified by first/second-generation immigrants and many cases may be preventable. Methods This was a nationwide study of children Results We identified 145 case…
Consonni F, Chiti N, Ricci S, Venturini E, Canessa C, et al.
Immune response to tuberculosis (TB) has been extensively studied in the past decades and classically involves cellular immunity. However, evidence suggests that humoral immunity may play a relevant role. Past studies regarding serum immunoglobulin (Ig) levels in TB are dated and…
Fichera G, Causin F, Cecchin D, Giraudo C
…y as well as of a pulmonary consolidation at CT suggested a diagnosis of tuberculosis which was then clinically confirmed. After treatment with ethambutol, rifampicin and isoniazid, pyrazinamide, and vitamin B6 (i.e., intensive treatment for two months followed by a continuation …
Mesman AW, Soto M, Coit J, Calderon R, Aliaga J, et al.
Background Rapid and accurate diagnosis of childhood tuberculosis (TB) is challenging because children are often unable to produce the sputum sample required for conventional tests. Stool is an alternative sample type that is easy to collect from children, and studies investigati…
Gebre M, Cameron LH, Tadesse G, Woldeamanuel Y, Wassie L
…and low bacillary load make microbiological confirmation of tuberculosis (TB) in children challenging. In this study, we conducted a systematic review and meta-analysis to assess the diagnostic accuracy of Xpert on stool for pediatric tuberculosis. Methods Our search included stu…