Showing 126–150 of 200 documents
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Roy A, Infantes-Lorenzo JA, de la Cruz ML, Domínguez L, Álvarez J, et al.
Tuberculosis (TB) in small ruminants is a neglected disease despite its major impact on goat and sheep production and the global public health. The awareness of the role of small ruminants in the epidemiology of animal TB has increased in the last two decades, however, there is a…
Emily A Kendall, Claudia M Denkinger, Adithya Cattamanchi, David W Dowdy, Jason R Andrews
…ponent tests. Therefore, when evaluating novel tuberculosis diagnostics, greater consideration should be given to characterising which segments of the disease spectrum are detected, how these segments overlap across tests, and how they are prioritised for detection. Understanding…
Juan José Villamarín Marrugo, Juan Manuel Naranjo Piñeros, Erwin Hernando Hernandez Rincon
**RATIONALE AND OBJECTIVES:** Access to diagnostic imaging in low- and middle-income countries (LMICs) is limited by scarce equipment, geographic barriers, weak digital infrastructure, and shortages of trained personnel. Artificial intelligence (AI) has emerged as a promising too…
Foster N, Cunnama L, McCarthy K, Ramma L, Siapka M, et al.
Background In South Africa, replacing smear microscopy with Xpert-MTB/RIF (Xpert) for tuberculosis diagnosis did not reduce mortality and was cost-neutral. The unchanged mortality has been attributed to suboptimal Xpert implementation. We developed a mathematical model to explore…
Hafsat U Ibrahim, Rayyan M Garba, Jameel I Ahmad, Kabiru Abdulsalam, Yasir N Jibril, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of morbidity and mortality in Nigeria, particularly among people living with HIV (PLWH), who face significantly higher risks of developing active TB. Conventional diagnostic methods such as sputum smear microscopy and ches…
Osorio L, Garcia JA, Parra LG, Garcia V, Torres L, et al.
…field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty. Main body A scoping review was conducted. Peer-reviewed and grey literature were searched using terms describing the targeted infectious diseases, diag…
Wannarat Pongpirul, Phanupong Phutrakool, Krit Pongpirul
…hese patterns reflect a gradual transition toward molecular diagnostics, which offer improved accuracy but remain underutilized in lower-tier settings. To address these gaps, we incorporated trend analyses confirming significant temporal shifts and propose a tiered TB screening f…
Milburn J, Suresh R, Doyle R, Jarvis JN
…. The epidemiology of CNSI varies globally and conventional diagnostics deployed in resource-limited settings have significant limitations, with an urgent need for improved diagnostic strategies. Areas covered This review describes molecular platforms and other novel diagnostics …
Mabe L, Muthevhuli M, Thekisoe O, Suleman E
Bovine tuberculosis (bovine TB) is a chronic wasting disease of cattle caused primarily by Mycobacterium bovis. Controlling bovine TB requires highly sensitive, specific, quick, and reliable diagnostic methods. This systematic review and meta-analysis evaluated molecular diagnost…
Chang Song, Ying-Xing Nong, Chun-Yan Zhao, Xue-Wen Huang, Ai-Chun Huang, et al.
**BACKGROUND:** To evaluate the diagnostic performance of targeted next-generation sequencing (tNGS) for tuberculosis (TB) in patients with human immunodeficiency virus (HIV) and to compare it with traditional diagnostic methods. **METHODS:** A total of 66 HIV patients were enro…
Liu C, Li X
Tuberculosis (TB) poses significant challenges due to its high transmissibility within populations and intrinsic resistance to treatment, rendering it a formidable respiratory disease with a substantial susceptibility burden. This study was designed to identify new potential ther…
Nadiia Tytarenko, John S Bimba, Didac Vulcano, Patricia Comella-Del-Barrio, Okoedoh Osazuwa, et al.
Tuberculosis (TB) remains a leading cause of death worldwide, with major diagnostic challenges in low-resource settings. Urine-based lipoarabinomannan (LAM) assays provide a non-invasive option, particularly for people living with HIV who may struggle to produce sputum. Fujifilm …
van der Pol S, Garcia PR, Postma MJ, Villar FA, van Asselt ADI
…time, new European regulations for market entry of in vitro diagnostics, in the form of the in vitro diagnostic regulation, may lead to more clinical evidence supporting health-economic analyses. Objective The objective of this systematic review was to review the methods used in …
Camagu Potelwa, Sheree Gray, Francois Malherbe, Christo Kloppers, David Richardson, et al.
**BACKGROUND:** In the HIV/tuberculosis endemic Western Cape public care setting, diagnostic consideration of patients with persistent lymphadenopathy focuses on extra-pulmonary tuberculosis (EPTB), delaying diagnosis of other infectious or malignant causes of lymphadenopathy. *…
Zhang Q, Ma Y, Zhang M, Wang Y, Wu W
Objective This study aimed to conduct a systematic review of the diagnostic value of interleukin-27 (IL-27) for tuberculous pleurisy (TP). Methods Literature on IL-27 diagnosis of TP was retrieved and screened from six databases (four English databases and two Chinese databases).…
Ghoweba Y, Safizadeh Shabestari SA, Malik ZA
Background Delays in diagnosis and treatment of central nervous system (CNS) infections can lead to significant morbidity and mortality among children and adults. Prior antibiotic treatment is a major hurdle to accurate diagnosis due to falsely negative cerebrospinal fluid (CSF) …
Rasheed W, Qureshi R, Jabeen N, Shah HA, Naseem Khan R
Introduction Pulmonary tuberculosis (PTB) is caused by species of organisms in the Mycobacterium tuberculosis complex. It is a major public health problem worldwide and is endemic in Pakistan. Various clinical and biochemical markers exist for its diagnosis. Radiology has an impo…
M Seifert, R E Colman, S Laurent, A De la Rossa, S Uplekar, et al.
**BACKGROUND:** Targeted next-generation sequencing has emerged as a rapid solution for diagnosing drug-resistant TB (DR-TB) directly from clinical specimens. Updating the bioinformatics software component can lead to rapid improvements in diagnostic performance. We compared the …
Boloko L, Schutz C, Sibiya N, Balfour A, Ward A, et al.
…f markers of critical-illness and compared with other rapid diagnostics (urine lipoarabinomannan and sputum Xpert). Quantitative blood Xpert Ultra results were evaluated as a disease biomarker by assessing association with disease phenotype defined by principal component analysis…
Patrycja Olszewska, Monika Spietelun, Katarzyna Syguła, Andrzej Ossowski, Bartłomiej Grygorcewicz
…fically infect bacteria, have emerged as a valuable tool in diagnostics due to their unique specificity and adaptability. This review explores the diverse applications of bacteriophages in diagnostic methods, from traditional phage typing to advanced molecular techniques such as …
Fuyong Liu, Zheng Li, Xuejiao Li, Wei Hong, Yanlin Zhou, et al.
**OBJECTIVE:** We developed and validated a diagnostic scoring system for tuberculous meningitis (TBM) using 13 laboratory parameters, comparing tuberculous meningitis (TBM) and non-tuberculous meningitis (non-TBM). **METHODS:** This study enrolled patients diagnosed with mening…
Kassa GM, Merid MW, Muluneh AG, Wolde HF
Background To end Tuberculosis (TB) by 2030, early detection and timely treatment of Drug-Resistant Tuberculosis (DR-TB) is vital. The role of rapid, accurate, and sensitive DR-TB diagnostic tool is indispensable to accelerate the TB control program. There are evidence breaks in …
Kafle G, Garg B, Mehta N, Sharma R, Singh U, et al.
Aims The aims of this study were to determine the diagnostic yield of image-guided biopsy in providing a final diagnosis in patients with suspected infectious spondylodiscitis, to report the diagnostic accuracy of various microbiological tests and histological examinations in the…
Luanne Karolyne Leal Dos Santos, Yan Mathias Alves, Reginaldo Bazon Vaz Tavares, Marcela Antunes Paschoal Popolin, Nathalia Zini, et al.
…rends and regional disparities in tuberculosis (TB) and HIV diagnostics in Brazil, examining the impacts of the COVID-19 pandemic and the uneven recovery of diagnostic services across different regions. **METHODS:** This nationwide ecological study analyzed monthly data on TB an…
Zhao CY, Song C, Lin YR, Nong YX, Huang AC, et al.
Background This study aimed to investigate the diagnostic value of nanopore sequencing technology in non-tuberculous mycobacterial pulmonary disease (NTMPD) and compare it with traditional culture methods. Methods A retrospective analysis was conducted on 225 suspected NTMPD pati…