Showing 126–150 of 192 documents
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Di Tanna GL, Khaki AR, Theron G, McCarthy K, Cox H, et al.
…ted with Xpert MTB/RIF. Methods We searched PubMed, Embase, ClinicalTrials.gov, and the Pan African Clinical Trials Registry from inception to Feb 1, 2018, for randomised controlled trials (RCTs) comparing the use of Xpert MTB/RIF with sputum smear microscopy as tests for tubercu…
Nida Khan, Muhammad Ahmar Khan, Naila Muzaffar, Ahmad Ismail, Abdul Ghafoor, et al.
…S:** This is a stepped wedge, cluster randomized controlled trial with economic evaluation and health related quality of life sub-studies. Modified all-oral 9-month regimen will be sequentially rolled-out compared with the standard all-oral 11-month regimen at 12 sites in Punjab,…
Charan J, Goyal JP, Reljic T, Emmanuel P, Patel A, et al.
…ention of TB in CLHIV. Methods We searched PubMed, Cochrane Clinical Trial Registry and Google Scholar from inception to December 2016. Any randomized controlled trial assessing the role of isoniazid for the prevention of TB in CLHIV was eligible for inclusion. The primary endpoi…
Katamba A, Mochizuki T, Nalugwa T, Nantale M, Oyuku D, et al.
… In this planned analysis of a pragmatic cluster-randomized trial in Uganda, we assessed whether a multicomponent strategy, including decentralized Xpert testing, decreased mortality among adults evaluated for TB. Methods Ten community health centers were randomized, using a comp…
Laura Olbrich, Bada Yang, Hayley Poore, Alia Razid, Brittney Sweetser, et al.
…racy of LC-aNAATs and LF-LAM separately in children, but in clinical practice the tests may be used concurrently, i.e. in 'parallel'. **OBJECTIVES:** To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory and stool specimens in children, and with LF-LA…
Ggita JM, Katahoire A, Meyer AJ, Nansubuga E, Nalugwa T, et al.
…sehold contacts who participated in a randomized controlled trial evaluating home sputum collection and delivery of TB results via SMS (Pan-African Clinical Trials Registry #201509000877140). We asked about feelings, beliefs, decisions, and behaviors in response to the SMS result…
Lung T, Marks GB, Nhung NV, Anh NT, Hoa NLP, et al.
… are unclear due to the absence of evidence from randomised trials. We assessed the costs and cost-effectiveness of an active case finding strategy in Vietnam, where there is a high prevalence of tuberculosis. Methods We conducted an economic evaluation alongside the Active Case …
Esmail A, Randall P, Oelofse S, Tomasicchio M, Pooran A, et al.
…is issue, we performed an open-label, randomized controlled trial in periurban informal settlements of Cape Town, South Africa, where we TB symptom screened 5,274 individuals using a community-based scalable mobile clinic. Some 584 individuals with HIV infection or symptoms of TB…
Saskia Janssen, Thanakorn Vongjarudech, Mats O Karlsson, Caryn M Upton, Anthony J Garcia-Prats, et al.
…upporting broader access to the 3HP regimen. **PAN AFRICAN CLINICAL TRIALS REGISTRY:** PACTR202306775627089, registration date June 15, 2023.
Goyal JP, Singh S, Bishnoi R, Bhardwaj P, Kaur RJ, et al.
…osis (TB). However, the evidence from randomized controlled trials (RCTs) is inconsistent. Objectives This systematic review and meta-analysis was performed to synthesize evidence regarding role of vitamin D versus placebo for the management of TB. Materials and methods We search…
Adrienne Katrin M Guiang-Valerio, Ma Theresa M Collante, Christine B Bernal
…re warranted to optimize pediatric treatment strategies. **CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER:** N/A. **SUPPLEMENTARY INFORMATION:** The online version contains supplementary material available at 10.1186/s41927-026-00630-2.
Fox GJ, Nhung NV, Cam Binh N, Hoa NB, Garden FL, et al.
…esistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with drug-resistant tuberculosis are lacking. Methods We conducted a double-blind, randomized, controlled tri…
Saidi SS, Abdul Manaf R
…s and methods A single-blinded, randomized controlled field trial study design was conducted in Melaka from September 2019 until August 2021, involving newly diagnosed PTB patients. The participants were randomized either into the intervention group (FASTEN intervention) or into …
Franco JV, Bongaerts B, Metzendorf MI, Risso A, Guo Y, et al.
…ed) and WHO Global Index Medicus, and the WHO International Clinical Trials Registry Platform (ICTRP) on 3 May 2023 (date of last search for all databases); we placed no restrictions on the language of publication. Selection criteria We included retrospective and prospective coho…
Manon Lounnas, Eden Ngu Masama, Samuel Beneteau, Kunda Kasakwa, Rodney Kaitano, et al.
…d questionnaire at all sites. This study is registered with ClinicalTrials.gov (NCT04203628) and the Pan African Clinical Trial Registry (PACTR202006814433059). **FINDINGS:** Of the 216 children enrolled between Jan 13, 2020, and Dec 31, 2021, 215 were included in the study and …
Schwab TC, Perrig L, Göller PC, Guebely De la Hoz FF, Lahousse AP, et al.
…ence Core Collection, Global Index Medicus, Google Scholar, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform for published and unpublished reports on targeted NGS for drug-resistant tuberculosis from Jan 1, 2005, to Oct 14, 2022, with updates to our…
Marks GB, Nguyen NV, Nguyen PTB, Nguyen TA, Nguyen HB, et al.
…ress. Methods We performed a cluster-randomized, controlled trial in Ca Mau Province, Vietnam, to evaluate the effectiveness of active community-wide screening, as compared with standard passive case detection alone, for reducing the prevalence of tuberculosis. Persons 15 years o…
Jackson-Morris A, Masyuko S, Morrell L, Kataria I, Kocher EL, et al.
…eb of Science, EMBASE, Global Health Database, and selected clinical trials registries. Eligible studies were published between 2010 and December 2022, available in English, and report health service delivery programs or policies for the selected disease dyads in LMICs. We identi…
Wang Q, Pang Y, Jing W, Liu Y, Wang N, et al.
… was the time to sputum culture conversion on solid medium. Clinical outcomes of patients were evaluated at the time of treatment completion. Of the 22 patients in the experimental group, 7 (31.8%) met the treatment criterion of "cure" and 1 (4.5%) "complete treatment," for a tot…
Singh A, Midha V, Kaur K, Mahajan R, Singh D, et al.
…e for induction of remission at 8 weeks. Trail registration Clinical Trials Registry of India [CTRI/2021/10/037641].
Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, et al.
…used in isolation for the detection of tuberculosis, but in clinical practice the tests may be used in parallel (i.e. LC-aNAAT in combination with LF-LAM). **OBJECTIVES:** To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory samples and LF-LAM on uri…
Shangguan Y, Guo W, Feng X, Shi Y, Li X, et al.
… is unclear. Methods We conducted an open-label, randomized trial in China, involving newly diagnosed, drug-susceptible pulmonary TB. The control group was treated with the standard 6-month regimen. The experimental group replaced ethambutol with faropenem for 2 months. The prima…
Franco JV, Bongaerts B, Metzendorf MI, Risso A, Guo Y, et al.
… WHO Global Index Medicus, as well as the WHO International Clinical Trials Registry Platform (ICTRP) on 3 May 2023 (date of last search for all databases). We placed no restrictions on the language of publication. Selection criteria We included retrospective and prospective coho…
Leeberk Raja Inbaraj, Vignes Anand Srinivasalu, Mukesh Kumar Sathya Narayanan, Adhin Bhaskar, Jefferson Daniel, et al.
…is, we searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, the Science Citation Index and BIOSIS previews, WHO Global Index Medicus, and Scopus databases, for articles published from Jan 1, 1946, to Oct 2, 2023, using specific search terms such as "Tuber…
Zeliang Yang, Zichun Ma, Zubi Liu, Peibo Li, Yuqin Liu, et al.
…ormance of tNGS was robust regardless of specimen types and clinical symptoms. tNGS also showed a detection potential for other coinfecting respiratory pathogens. More than 90% of tNGS-positive individuals gained drug susceptibility results, which were mainly dependent on bacteri…