Showing 126–150 of 200 documents
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Aaby P, Benn CS
…s are increasingly reporting non-specific effects (NSEs) of vaccines; i.e. vaccines may affect the risk and severity of non-targeted infections. We reviewed how epidemiological studies developed the concept of beneficial NSEs of live vaccines. Sources This is a personal narrative…
Cobelens F, Suri RK, Helinski M, Makanga M, Weinberg AL, et al.
…s. Determining the public health impact of new tuberculosis vaccines requires understanding of a country's demand for a new tuberculosis vaccine, how to integrate vaccine implementation with ongoing tuberculosis prevention efforts, cost, and national and global demand to stimulat…
Yang Y, Xue Y, Wang X, Wang L, Wang J, et al.
…aluate the biological characteristics and immunogenicity of vaccines can improve the efficiency of vaccine development. Objectives To evaluate the immunogenicity of TB vaccine W541 and to explore the application of bioinformatics technology in TB vaccine research. Methods This st…
Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, et al.
The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased immune sig…
Usher NT, Chang S, Howard RS, Martinez A, Harrison LH, et al.
…iated with lung cancer and the availability of low-cost BCG vaccines.
Lee S, Lee K, Park J, Jeong YD, Jo H, et al.
…inal adverse drug reactions (ADRs) associated with COVID-19 vaccines, literature on such ADRs with other vaccines is limited, particularly on a global scale. Therefore, we aimed to investigate the global burden of vaccine-associated hepatobiliary and gastrointestinal ADRs and ide…
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, et al.
Background BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate th…
Portnoy A, Clark RA, Quaife M, Weerasuriya CK, Mukandavire C, et al.
…liminating it has proven challenging. Safe and effective TB vaccines that can rapidly reduce disease burden are essential for achieving TB elimination. We assessed future costs, cost-savings, and cost-effectiveness of introducing novel TB vaccines in low- and middle-income countr…
Sumner T, Clark RA, Prys-Jones TO, Bakker R, Churchyard G, et al.
…(PWH) are at an increased risk of tuberculosis (TB). New TB vaccines may help reduce this burden. New TB vaccine candidates are well tolerated and immunogenic in PWH. There are currently limited data on vaccine efficacy in this population. Methods Using mathematical modeling, we …
Scarponi D, Clark RA, Weerasuriya CK, Emery J, Houben RMGJ, et al.
…sively to estimate the potential impact of new tuberculosis vaccines, with the majority of existing models assuming that individuals with Mycobacterium tuberculosis (Mtb) infection remain at lifelong risk of tuberculosis disease. Recent research provides evidence that self-cleara…
Albutti A
…o overcome literature reported limitations of epitope-based vaccines, I carried out additional analysis by designing a multi-epitopes vaccine to achieve maximum protective immunity as well as to make experimental follow up studies easy by selecting a vaccine that can be easily an…
Kate Bisset, Georgia Chisnall, Colin N J Campbell, Vanessa Saliba, Sandra Mounier-Jack, et al.
**BACKGROUND:** The neonatal Bacillus Calmette-Guérin (BCG) selective vaccination pathway in England was revised in September 2021 due to the introduction of a national evaluation of newborn screening for Severe Combined Immunodeficiency (SCID). BCG is a live attenuated vacc…
Maltezou HC, Botelho-Nevers E, Brantsæter AB, Carlsson RM, Heininger U, et al.
We investigated and compared current national vaccination policies for health-care personnel (HCP) in Europe with results from our previous survey. Data from 36 European countries were collected using the same methodology as in 2011. National policies for HCP immunization were in…
Mushtaq Ahmed, Shibali Das, Bruce A Rosa, Javier Rangel Moreno, Deepak Kaushal, et al.
**UNLABELLED:** Tuberculosis (TB), caused by the bacterium(), infects approximately one-fourth of the world's population. Inbred mouse models of TB do not reflect the pathological states and heterogeneity seen in human TB disease. Thus, we recently established a model of TB in di…
Weerasuriya CK, Harris RC, Quaife M, McQuaid CF, White RG, et al.
New tuberculosis vaccines have made substantial progress in the development pipeline. Previous modelling suggests that adolescent/adult mass vaccination may cost-effectively contribute towards achieving global tuberculosis control goals. These analyses have not considered the bud…
Nasiri MJ, Silva DR, Rommasi F, Zahmatkesh MM, Tajabadi Z, et al.
…he following keywords were used: tuberculosis, vaccination, vaccines and PTLD. PubMed/MEDLINE and Embase were used as the search engine, focusing on English-language literature only. Results We identified 9 vaccines potentially useful in PTLD. Influenza, pneumococcal and anti-COV…
de Bree LCJ, Mourits VP, Koeken VA, Moorlag SJ, Janssen R, et al.
…o account when studying specific and nonspecific effects of vaccines; early morning should be the preferred moment of BCG administration.FUNDINGThe Netherlands Organization for Scientific Research, the European Research Council, and the Danish National Research Foundation.
Owusu DO, Adankwah E, Aniagyei W, Acheampong I, Minadzi D, et al.
Mycobacterium (M.) bovis BCG vaccination is recommended for healthy babies after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing severe clinical manifestations of…
Ferrara Muñiz X, García E, Blanco FC, Garbaccio S, Garro C, et al.
Background/Objectives : Vaccines may improve the control and eradication of bovine tuberculosis. However, the evaluation of experimental candidates requires the assessment of the protection, excretion, transmission and biosafety. A natural transmission trial among likely infected…
M J Nasiri, D R Silva, F Rommasi, M M Zahmatkesh, Z Tajabadi, et al.
…he following keywords were used: tuberculosis, vaccination, vaccines and PTLD. PubMed/MEDLINE and Embase were used as the search engine, focusing on English-language literature only. **RESULTS:** We identified 9 vaccines potentially useful in PTLD. Influenza, pneumococcal and an…
Zimmermann P, Donath S, Perrett KP, Messina NL, Ritz N, et al.
… Calmette-Guérin vaccine (BCG), one of the most widely used vaccines, does not only provide protection against tuberculosis and other mycobacterial infections, but also has non-specific (heterologous) immunomodulatory effects. In participants in a randomised trial, we investigate…
Voss G, Casimiro D, Neyrolles O, Williams A, Kaufmann SHE, et al.
…nable head-to-head comparison and selection of candidate TB vaccines for further development. To extend our understanding of the safety and immunogenicity of TB vaccines we have performed experimental medicine studies to explore route of administration and have begun to develop c…
Singh AD, Upal N, Oberoi S, Singh N, Garg A, et al.
…ut the willingness and perceptions of PLHIV regarding these vaccines. Therefore, we explored vaccine awareness and hesitancy, especially during the recent COVID-19 pandemic. Objectives The primary objective was to determine the uptake of the Covid-19 vaccine and other VPD's among…
Kaufmann SHE
…acille Calmette-Guérin (BCG), it is insufficient and better vaccines are urgently needed. This treatise describes first the basic immunology and pathology of TB with an emphasis on the role of T lymphocytes. Better understanding of the immune response to Mycobacterium tuberculosi…
Ford A, Hwang A, Mo AX, Baqar S, Touchette N, et al.
…dvances and recent progress in research and development for vaccines and immunization, critically reviewed lessons learned from COVID-19 vaccine programs, and looked ahead to opportunities for this decade. For COVID-19, decades of investments in basic and translational research, …