Showing 126–150 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Nonghanphithak D, Chaiprasert A, Smithtikarn S, Kamolwat P, Pungrassami P, et al.
Multidrug-resistant tuberculosis (MDR TB), pre-extensively drug-resistant tuberculosis (pre-XDR TB), and extensively drug-resistant tuberculosis (XDR TB) complicate disease control. We analyzed whole-genome sequence data for 579 phenotypically drug-resistant M. tuberculosis isola…
Dagli N, Haque M, Kumar S
…ovides a comprehensive overview of the current landscape in drug-resistant tuberculosis research. An extensive electronic search was conducted on PubMed and Scopus databases to identify clinical trials related to drug-resistant tuberculosis. Network analysis and visualization wer…
Sheng-Han Wu, Hsin-Yi Liu, Kuang-Hung Liu, Hseuh-Chien Hsiao, Ruwen Jou
Cycloserine (CS) is a widely used drug for drug-resistant tuberculosis (DR-TB) treatment. The World Health Organization (WHO) recently suggested a critical concentration (CC) for CS using the MGIT 960 system (MGIT). To strengthen our DR-TB management program, we performed CS resi…
Sharma D, Bisht D, Khan AU
… the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis . Apart from principal targets of resistance, many explanations have been proposed for drug resistance but…
Yannan Xu, Sixuan Liu, Jiaxiong Zheng, Jianxiong Lin, Liwei Gi, et al.
**BACKGROUND:** The situation of drug-resistant tuberculosis in China remains serious and complex. The majority of the study data are still derived from the 2,207 national survey of drug-resistant tuberculosis. In this study, we aimed to comprehensively characterize the prevalenc…
Rabaan AA, Mutair AA, Albayat H, Alotaibi J, Sulaiman T, et al.
… either asymptomatic or not diagnosed, and the frequency of drug resistance is increasing due to intrinsically linked factors from both host and bacterium. For instance, poor access to TB diagnosis and reduced treatment in the era of the COVID-19 pandemic has resulted in more TB …
Bhagwat A, Deshpande A, Parish T
Drug resistance is an increasing problem for the treatment of tuberculosis. The prevalence of clinical isolates with pre-existing resistance needs to be considered in any drug discovery program. Non-specific mechanisms of resistance such as increased efflux or decreased permeabil…
Pei S, Song Z, Yang W, He W, Ou X, et al.
…erium tuberculosis complex (MTBC) mutations associated with drug resistance in 2021. However, country-specific issues might lead to arising complex and additional drug-resistant mutations. We aimed to fully reflect the characteristics of drug resistance mutations in China. Method…
Téllez-Navarrete NA, Ramon-Luing LA, Muñoz-Torrico M, Preciado-García M, Medina-Quero K, et al.
…ing is required to maintain Treg. Methods A blood sample of drug-susceptible (DS-TB) and drug-resistant tuberculosis (DR-TB) patients was obtained before (basal) and after 2 and 6 months of anti-TB therapy. Expression of TNF, TNFR1, and TNFR2 (transmembrane form, tm) on cTreg, uT…
Theron G, Limberis J, Venter R, Smith L, Pietersen E, et al.
A burgeoning epidemic of drug-resistant tuberculosis (TB) threatens to derail global control efforts. Although the mechanisms remain poorly clarified, drug-resistant strains are widely believed to be less infectious than drug-susceptible strains. Consequently, we hypothesized tha…
Juexin Wang, Chan Chen, Huan Fang, Yong Liao, Qiong Lei, et al.
**OBJECTIVE:** The study aimed to understand the drug resistance profile and transmission characteristics of drug-resistant(MTB) in Ganzhou, China, to provide a scientific basis for developing prevention and control strategies. **METHODS:** DNA extracted from re-cultured positiv…
Maryam Gul, Sajid Ali, Abdul Rehman, Muhammad Qasim, Roomana Ali, et al.
**BACKGROUND:** Resistance to first-line anti-tuberculosis drugs inrepresents a significant public health challenge, particularly in high-burden tuberculosis (TB) settings such as Pakistan, where multidrug-resistant (MDR) forms further complicate disease control efforts. Drug res…
Kumar V, Jorwal P, Soneja M, Sinha S, Nischal N, et al.
Background Early diagnosis and treatment of drug-resistant tuberculosis (TB) is crucial to halt the spread of drug resistance in the community. Aim The aim of the study was to compare rapid diagnostic tests (GeneXpert and line probe assay, LPA) with conventional liquid culture fo…
He G, Zheng Q, Shi J, Wu L, Huang B, et al.
…ncing (WGS), has greatly facilitated the early diagnosis of drug-resistant tuberculosis patients. Nonetheless, the interpretation of results from various types of mutations in drug-resistant-associated genes has become the primary challenge in the field of molecular drug-resistan…
Deelder W, Christakoudi S, Phelan J, Benavente ED, Campino S, et al.
…to existing treatments threatens to derail control efforts. Resistance is mainly conferred by mutations in genes coding for drug targets or converting enzymes, but our knowledge of these mutations is incomplete. Whole genome sequencing (WGS) is an increasingly common approach to …
Mekonnen D, Munshea A, Nibret E, Adnew B, Getachew H, et al.
Introduction Drug resistance (DR) in Mycobacterium tuberculosis complex (MTBC) is mainly associated with certain lineages and varies across regions and countries. The Beijing genotype is the leading resistant lineage in Asia and western countries. M. tuberculosis (Mtb) (sub) line…
Barilar I, Fernando T, Utpatel C, Abujate C, Madeira CM, et al.
…d. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants of rifampicin-resistant and MDR tuberculosis in Mozambique. Methods In this retrospective observational stud…
Tang C, Xu F, Zheng X, Xiang G
…he leading cause of human mortality in infectious diseases. Drug-resistant TB, particularly multidrug-resistant TB and extensively drug-resistant TB, poses a pressing clinical and public health challenge. The main causative agents of TB are known as Mycobacterium tuberculosis (MT…
Köhler N, Karaköse H, Grobbel HP, Hillemann D, Andres S, et al.
The treatment of drug-resistant Mycobacterium tuberculosis relies on complex antibiotic therapy. Inadequate antibiotic exposure can lead to treatment failure, acquired drug resistance, and an increased risk of adverse events. Therapeutic drug monitoring (TDM) can be used to optim…
Liebenberg D, Gordhan BG, Kana BD
Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial resistance, often consuming a large proportion of the healthcare budget and associated resources in many endemic countries. The rapid emergence of resistance to newer tuberculosis therapie…
Yao L, Wang B, Chen X, Liu Q, Sheng J, et al.
…uate the safety and efficacy of decortication for stage III drug-resistant tuberculous empyema (TE). Methods We analysed all patients with stage III TE who underwent decortication between March 2015 and October 2019 at Wuhan Pulmonary Hospital. The patients were divided into 2 gr…
Zürcher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, et al.
Background Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and whole-genome sequencing (…
Kim S, Seo H, Mahmud HA, Islam MI, Lee BE, et al.
… disease that threatens humanity, and the emergence of multidrug-resistant (MDR), extensively drug-resistant (XDR) strains resistant to drugs suggests that new drug development is urgent. In order to develop new tuberculosis drug, we have conducted in vitro anti-tubercular tests …
Kardan-Yamchi J, Kazemian H, Haeili M, Harati AA, Amini S, et al.
Objectives Active extrusion of antituberculosis drugs via efflux pumps (EPs) has been suggested as contributing to drug resistance in Mycobacterium tuberculosis. This study was conducted to determine the role of 10 drug efflux transporters in the development of drug resistance in…
Bao X, Liang S, Li J, Ye Q, Wu D, et al.
…ssess the prevalence and control effect of tuberculosis and drug-resistant tuberculosis (TB) in Anhui province, and analyze the trends in the changing drug resistance spectrum of Mycobacterium tuberculosis (Mtb) isolated in Anhui province from 2016 to 2022. Methods From 2016 to 2…