Showing 101–125 of 200 documents
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Liang Y, Li X, Yang Y, Xiao L, Liang Y, et al.
…round About a quarter of the world's population with latent tuberculosis infection (LTBI) are the main source of active tuberculosis. Bacillus Calmette Guerin (BCG) cannot effectively control LTBI individuals from developing diseases. Latency-related antigens can induce T lymphoc…
Winglee K, Hill AN, Belknap R, Stout JE, Ayers TL
…ERON Gold In-Tube (QFT), are important diagnostic tools for tuberculosis infection, but little work has been done to study the performance of these tests in populations prioritized for tuberculosis testing in the United States, especially those other than health care personnel. M…
Kase AM, Libertin CR, Roy A
…anti-TNF pharmaceuticals increases the risk of reactivating tuberculosis making screening for latent tuberculosis infection (LTBI) a requirement prior to initiating therapy. Case A middle-aged male from China with a past medical history of LTBI and Crohn's disease, previously on …
Carlos Brito, Rita Moraes de Brito
…he article "Brazilian Recommendations for the Management of Tuberculosis Infection in Immune-Mediated Inflammatory Diseases" by Viviane de Souza et al. presents important discussions on the subject; however, the recommendation for annual repetition of the TST/IGRA test for three …
He J, Fan Y, Shen D, Yu M, Shi L, et al.
Background Tuberculosis (TB) is an infectious disease and its mortality rate ranks first. Latent tuberculosis infection (LTBI) means that a patient is infected with Mycobacterium tuberculosis, but has no relative clinical symptoms. It has been estimated that approximately 10% of …
Stockbridge EL, Miller TL, Carlson EK, Ho C
…Targeted identification and treatment of people with latent tuberculosis infection (LTBI) are key components of the US tuberculosis elimination strategy. Because of recent policy changes, some LTBI treatment may shift from public health departments to the private sector. Objectiv…
Herrera M, Keynan Y, López L, Marín D, Arroyave L, et al.
…f liberty (PDL) are at high risk of acquiring Mycobacterium tuberculosis infection (latent tuberculosis infection [LTBI]) and progressing to active tuberculosis (TB). We sought to determine the incidence rates and factors associated with LTBI and active TB in Colombian prisons. U…
Gaensbauer J, Aiona K, Haas M, Reves R, Young J, et al.
…ve the highest age-specific rate of progression from latent tuberculosis infection (LTBI) to active disease. Therefore, regimens for treatment of pediatric LTBI must be not only efficacious but practical enough to overcome the unique childhood barriers to regimen adherence. Since…
Araujo Z, de Waard JH, Camargo M, Lopez-Ramos JE, de Larrea CF, et al.
Diagnosis and treatment of active tuberculosis (ATB) as well as latent tuberculosis infection (LTBI) are required for effective tuberculosis (TB) control, especially in TB endemic area. The usefulness of conventional tests to distinguish between ATB and LTBI has remained challeng…
Alebouyeh S, Weinrick B, Achkar JM, García MJ, Prados-Rosales R
Tuberculosis (TB) is a global disease caused by Mycobacterium tuberculosis ( Mtb ) and is manifested as a continuum spectrum of infectious states. Both, the most common and clinically asymptomatic latent tuberculosis infection (LTBI), and the symptomatic disease, active tuberculo…
Xiao Xiao, Zhipeng Li, Jing Chen, Xin Shen
**BACKGROUND:** Students represent a key demographic for tuberculosis (TB) control in China. This study utilizes a dynamic Markov model to forecast the epidemiological trends of active tuberculosis (ATB) among students in Shanghai through 2035 and evaluate the effectiveness of di…
Khayat M, Fan H, Vali Y
…this culminated in a microbiological diagnosis of pulmonary tuberculosis. The patient's daughter had been treated for tuberculosis two years earlier and unfortunately family screening for latent TB was not undertaken. This case appears to confirm the concerns that the CD4 + T-cel…
Bintang Yinke Magdalena Sinaga, Jelita Siregar, Delores Elisabeth Sormin, Rina Sundari, Yoseph Leonardo Samodra
…TIVE:** The WHO advises the detection of cases of pulmonary tuberculosis (TB) in household contacts (HHCs). This activity allows for testing family members of TB patients for latent tuberculosis infection (LTBI) and detecting factors associated with LTBI. The purpose of this stud…
Liu J, Li Y, Liu T, Shi Y, Wang Y, et al.
Background Mycobacterium tuberculosis (Mtb) survives inside a human host for a long time in the form of latent tuberculosis infection (LTBI). Latent infection of tuberculosis has the opportunity of developing into active tuberculosis (ATB), which has greatly endangered human heal…
Namuganga AR, Nsereko M, Bagaya BS, Mayanja-Kizza H, Chegou NN
…ckground There is a need for new tools for the diagnosis of tuberculosis (TB) amongst patients who present at primary health care centers with symptoms suggestive of TB. Objectives To assess the abilities of selected blood-based host biomarkers to discriminate between patients wh…
Yu Q, Yan J, Tian S, Weng W, Luo H, et al.
…n clinical metrics to discriminate between active pulmonary tuberculosis (APTB) and inactive pulmonary tuberculosis (IPTB). Patients and methods A total of 1096 patients with pulmonary tuberculosis (PTB) admitted to Wuhan Jinyintan Hospital between January 2017 and December 2019 …
VanValkenburg A, Kaipilyawar V, Sarkar S, Lakshminarayanan S, Cintron C, et al.
Background Most individuals exposed to Mycobacterium tuberculosis (Mtb) develop latent tuberculosis infection (LTBI) and remain at risk for progressing to active tuberculosis disease (TB). Malnutrition is an important risk factor driving progression from LTBI to TB. However, the …
Tesfaye F, Sturegård E, Walles J, Bekele B, Bobosha K, et al.
The immune control of tuberculosis (TB) infection could be influenced by pregnancy. To elucidate this, we longitudinally characterized Mycobacterium tuberculosis (Mtb)-specific and nonspecific immune responses in women during pregnancy and postpartum. HIV-uninfected women without…
Nunes JES, Duque MA, de Freitas TF, Galina L, Timmers LFSM, et al.
…orld's population is estimated to have latent Mycobacterium tuberculosis infection, being at risk of developing active tuberculosis (TB) during their lifetime. Given the inefficacy of prophylactic measures and the increase of drug-resistant M. tuberculosis strains, there is a cle…
Luo Y, Xue Y, Liu W, Song H, Huang Y, et al.
Background The discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. The present study aims to investigate the value of diagnostic models established by machine learning based on multiple laboratory data for distinguishing …
Haiping Dong, Bin Huang, Haobin Kuang, Hua Li, Yuan Yuan, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a significant global health threat, with latent tuberculosis infection (LTBI) serving as a major reservoir for new TB cases. This study aimed to identify antigens capable of distinguishing between active tuberculosis (ATB) and LTBI in i…
Stringari LL, Covre LP, da Silva FDC, de Oliveira VL, Campana MC, et al.
…y T cells (Tregs) play a critical role during Mycobacterium tuberculosis (Mtb) infection, modulating host responses while neutralizing excessive inflammation. However, their impact on regulating host protective immunity is not completely understood. Here, we demonstrate that Treg…
Xi X, Wang B, Zhang R, Ling C
…xosome tRFs/tiRNAs and to explore their diagnostic value in tuberculosis (TB) activity. Methods The serum exosome tRF/tiRNA profile was analysed using high-throughput sequencing technology in 5 active tuberculosis (ATB) patients, 5 latent tuberculosis infection (LTBI) patients an…
Yue Wang, Rukeyamu Abudushalamu, Xiaoming Peng, Kadierya Nasier, Zihao Teng, et al.
…istic gut microbial alterations in Han patients with active tuberculosis (TB) and those with latent tuberculosis infection (LTBI). The findings are expected to support tailored strategies for the regional prevention and control of tuberculosis. **METHODS:** A total of 51 cases o…
Luo Y, Xue Y, Song H, Tang G, Liu W, et al.
Background Discriminating active tuberculosis (ATB) from latent tuberculosis infection (LTBI) remains challenging. The present study aims to evaluate the performance of diagnostic models established using machine learning based on routine laboratory indicators in differentiating …