Showing 101–125 of 200 documents
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Wademan DT, Busakwe L, Nicholson TJ, van der Zalm M, Palmer M, et al.
… acceptability of a novel fixed-dose combination (FDC) anti-tuberculosis drug. This study was nested in the SHINE (Shorter treatment for minimal TB in children) trial, which compares the safety and efficacy of treating non-severe drug-susceptible tuberculosis (TB) with a 6 vs. 4 …
Amorim G, Jaworski J, Yang J, Cordeiro-Santos M, Kritski AL, et al.
…Genetic polymorphisms have been associated with risk of antituberculosis treatment toxicity. We characterized associations with adverse events and treatment failure/recurrence among adults treated for tuberculosis in Brazil. Methods Participants were followed in Regional Prospect…
Santos F, Pires D, Anes E, Duarte ARC
…ivity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to t…
Bhaskar A, Kumari A, Singh M, Kumar S, Kumar S, et al.
The currently available anti-tuberculosis treatment (ATT) comprises exclusively of anti-bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the generation of drug-resistant variants. Therefore, a combination therapy directed against the pathogen an…
Ondiro J, Onyangore F, Onyango R, Muema L, Aduda DSO
Background Tuberculosis program effectiveness is majorly measured by disease severity and treatment response without integrating patient perspectives. Yet, it's a critical dimension in clinical decision-making that enhances health worker-patient interactions and increases individ…
Elsayed ZM, Eldehna WM, Abdel-Aziz MM, El Hassab MA, Elkaeed EB, et al.
Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids ( 5a-m and 9a-c ) as promising anti-tubercular and antibacterial agents. The anti-tubercular activity of…
Chang VK, Imperial MZ, Phillips PPJ, Velásquez GE, Nahid P, et al.
…pentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. The primary efficacy outcome was 12-month tuberculosis disease free survival, while the primary safety outcome was the proportion of grade 3 or higher adverse events during the treatm…
Zheng X, Gui X, Yao L, Ma J, He Y, et al.
In preclinical studies, a new antituberculosis drug regimen markedly reduced the time required to achieve relapse-free cure. This study aimed to preliminarily evaluate the efficacy and safety of this four-month regimen, consisting of clofazimine, prothionamide, pyrazinamide and e…
Rens NE, Uyl-de Groot CA, Goldhaber-Fiebert JD, Croda J, Andrews JR
… and resulting toxicity and effectiveness of drugs used for tuberculosis treatment. For isoniazid, mutations in the N-acetyltransferase 2 (NAT2) gene explain >88% of pharmacokinetic variability. However, weight-based dosing remains the norm globally. The potential clinical impact…
Fox WS, Strydom N, Imperial MZ, Jarlsberg L, Savic RM
Aims Adherence has been shown to be a major predictor of tuberculosis treatment failure and relapse. The current adherence metrics can be improved to provide higher resolution of adherence patterns and identify patients in need of alternative treatment interventions. We investiga…
Karolina Kėvelaitienė, Roma Puronaitė, Valerija Edita Davidavičienė, Birutė Nakčerienė, Edvardas Danila
…reatment outcomes of adults with pulmonary drug-susceptible tuberculosis (DS-TB) in Lithuania over 22 years, and to examine associations between treatment outcomes, various risk factors, and temporal trends.: A retrospective cohort analysis was conducted using data from the Natio…
Zha BS, Nahid P
Mycobacterium tuberculosis is a major public health concern and requires prompt treatment. Goals of treatment include curing the individual patient and protecting the community from ongoing tuberculosis transmission. To achieve durable cure, regimens must include multiple agents …
Elias Jabbour, Marcia Pinto, Ricardo E Steffen, Fernanda Dockhorn, Daniele M Pelissari, et al.
**INTRODUCTION:** To eliminate tuberculosis (TB) in Brazil, scaling up screening and prevention strategies will be essential. We estimated costs of TB services in Brazil to support budgeting, cost-effectiveness analysis and inform the implementation of these strategies. **METHOD…
Denti P, Wasmann RE, van Rie A, Winckler J, Bekker A, et al.
… (WHO) revised dosing guidelines for treatment of childhood tuberculosis. Our aim was to investigate first-line antituberculosis drug exposures under these guidelines, explore dose optimization using the current dispersible fixed-dose combination (FDC) tablet of rifampicin/isonia…
Wang Y, Yin S, Wang S, Rong K, Meng XH, et al.
…es a formidable challenge to the worldwide campaign against tuberculosis (TB), particularly in developing countries. The frequent reports of suboptimal treatment outcomes, complications, and the absence of definitive treatment guidelines for Rifampicin-resistant spinal TB (DSTB) …
Naidoo K, Dookie N, Naidoo K, Yende-Zuma N, Chimukangara B, et al.
Background Recurrent tuberculosis (TB) following TB treatment completion in HIV-infected individuals remains a major public health burden. We assessed the role of various risk factors in mediating the development of recurrent TB and subsequent resistance to antiretroviral therapy…
Maserumule MC
… a successful host response to infection with Mycobacterium tuberculosis (MTB) which causes human tuberculosis (TB). Better understanding of host factors controlling the survival of MTB within the macrophage (the primary site of MTB infection) may present potentially more effecti…
Elmadbouly AA, Abdul-Mohymen AM, Eltrawy HH, Elhasan HAA, Althoqapy AA, et al.
Background Drug-resistant Tuberculosis (DR-TB) is a global health burden with high morbidity and mortality in developing countries including Egypt. The susceptibility to infection with DR-TB strains may be genetically determined. Several interleukin gene polymorphisms were invest…
Shambhu R, Tank PAM, Mir T, Hegde V, Kibballi Madhukeshwar A
…rompt treatment may be sight-saving in patients with Ocular Tuberculosis (TB). Patients on anti tubercular treatment (ATT) also need ophthalmological examination at the start of the treatment and monitoring for toxic optic neuropathy regularly till the completion of treatment. Th…
Le H, Nguyen N, Tran P, Hoa N, Hung N, et al.
…ely), recommends prompt initiation of likely effective anti-tuberculosis treatment informed by Xpert ® MTB/RIF results . OBJECTIVE: To describe FAST implementation at Quang Nam Provincial TB and Lung Disease Hospital (QNH), Tam Ky, Viet Nam, using time to initiation of effective …
Chen Y, Chen Y, Jiang Q, Zou J, Yang T, et al.
…te the minimum level of heteroresistance that predicts poor tuberculosis treatment outcomes. This retrospective study enrolled 45 new tuberculosis patients with varied treatment outcomes and 16 drug-susceptible retreatment cases. Pretreatment isolates from these 61 patients were …
Said BN, Heysell SK, Yimer G, Aarnoutse RE, Kibiki GS, et al.
… Suboptimal drug exposure in patients with drug-susceptible tuberculosis (DS-TB) can drive treatment failure. Pharmacodynamics (PD) biomarkers such as the plasma TB drug-activity (TDA) assay may guide dose finding studies and predict microbiological outcomes differently than conv…
Peetluk LS, Rebeiro PF, Ridolfi FM, Andrade BB, Cordeiro-Santos M, et al.
…ground Despite widespread availability of curative therapy, tuberculosis (TB) treatment outcomes remain suboptimal. Clinical prediction models can inform treatment strategies to improve outcomes. Using baseline clinical data, we developed a prediction model for unsuccessful TB tr…
Mashele SA, Steel HC, Matjokotja MT, Rasehlo SSM, Anderson R, et al.
…herapeutic regimens of patients with drug-susceptible (DS)- tuberculosis (TB) comprise four primary anti-TB drugs: rifampicin (RMP), isoniazid (INH), ethambutol (EMB) and pyrazinamide (PZA), administered for six-to-nine months. These drug regimens target the various microbial pop…
Lee S, Aung MN, Kawatsu L, Uchimura K, Miyahara R, et al.
…teristics and treatment outcomes of overseas-born pulmonary tuberculosis (PTB) patients in Japan, and identify the factors associated with "treatment non-success". We conducted a retrospective analysis of overseas-born patients with drug-susceptible PTB using cohort data of PTB c…