Showing 101–125 of 200 documents
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Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, et al.
Background The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found u…
Singhal R, Dayal R, Bhatnagar S, Nayak M, Yadav N, et al.
…d as compared to CBNAAT in gastric aspirate (GA) samples in pediatric tuberculosis (TB). Methods This cross-sectional study was performed at Department of Pediatrics of a tertiary care hospital. Children aged 0-18 y diagnosed as presumptive tuberculosis were consecutively enrolle…
Farina E, D'Amore C, Lancella L, Boccuzzi E, Ciofi Degli Atti ML, et al.
Background Intercepting earlier suspected TB (Tuberculosis) cases clinically is necessary to reduce TB incidence, so we described signs and symptoms of retrospective cases of pulmonary TB and tried to evaluate which could be early warning signs. Methods We conducted a retrospecti…
Maphalle LNF, Michniak-Kohn BB, Ogunrombi MO, Adeleke OA
Managing pediatric tuberculosis (TB) remains a public health problem requiring urgent and long-lasting solutions as TB is one of the top ten causes of ill health and death in children as well as adolescents universally. Minors are particularly susceptible to this severe illness t…
Raizada N, McDowell A, Parija D, Sachdeva KS, Khaparde SD, et al.
Background A significant proportion of pediatric tuberculosis (TB) patients go unnotified due to the challenges in diagnosis of TB among children. The experiences of this vulnerable group while going through the TB care cascade remain largely undocumented. The aim of this study w…
Saldaña N, Parra M, La Garza E, Trujillo D, Ayala S, et al.
…to WHO data, in 2016 10.4 million people were infected with tuberculosis (TB), from which one million were patients ≤18 years, and 250,000 deaths. The diagnosis of TB in pediatric patients is a challenge given the clinical behavior. Methods This is a retrospective, descriptive, a…
Khurana AK, Dhingra B
Tuberculosis continues to haunt mankind since its discovery more than a century ago. Although commendable advancements have been made in the diagnosis as well as treatment, especially in the last couple of decades, the healthcare burden of this disease worldwide is immense. Conti…
Santos ACEZ, Sztajnbok J, Duarte-Neto AN, Sousa AFT, Lopes AGD, et al.
Disseminated tuberculosis is a severe disease with high-mortality that requires early diagnosis and treatment. Intestinal tuberculosis accounts for only 2% of tuberculosis cases worldwide and is extremely rare in children. We report a case of a 4-year-old girl admitted due to dis…
Diwan Israr Khan, Sana Jameel
**BACKGROUND:** Tuberculosis is a common systemic bacterial infectious disease usually caused by Mycobacterium tuberculosis. In India, there are an estimated 2.1 million cases of tuberculosis, with 16% of them being new extrapulmonary tuberculosis cases. Extrapulmonary tuberculos…
Kin-Sun Wong, Yen-Chun Huang, Han-Chung Hu, Yhu-Chering Huang, Chang-Hui Wen, et al.
…he tuberculin skin test (TST) in Taiwanese children for the diagnosis of active tuberculosis (TB). **METHODS:** A retrospective chart analysis of pediatric patients (<18 years of age) who underwent QFG-IT tests and TST for the confirmation of active TB between January 2008 and J…
Kalra A, Parija D, Raizada N, Sachdeva KS, Rao R, et al.
Background Diagnosis of TB in pediatric population poses several challenges. A novel initiative was implemented in several major cities of India aimed at providing upfront access to free-of-cost Xpert MTB/RIF to presumptive pediatric TB cases. This paper aims to describe the expe…
Osorio N, Reyes MM
Tuberculosis is one of the most common infectious diseases around the world. With timely diagnosis and treatment, mortality in children is practically zero. It is usually associated with a diverse number of complications that can cause significant morbidity and mortality, such as…
Daniel Capellán-Martín, Juan J Gómez-Valverde, Ramón Sánchez-Jacob, Alicia Hernanz-Lobo, H Simon Schaaf, et al.
Tuberculosis (TB) remains a major global health burden, particularly in low-resource, high-prevalence regions. Pediatric TB diagnosis poses challenges with non-specific symptoms and less distinct radiological manifestations than adult TB. Many affected children remain undiagnosed…
Adusumelli Y, Tabatneck M, Sherman S, Lamb G, Sabharwal V, et al.
…00 US children and adolescents are estimated to have latent tuberculosis (TB) infection. Identifying facilitators and barriers to engaging in TB infection care is critical to preventing pediatric TB disease. We explored families' and clinicians' perspectives on pediatric TB infec…
Villar-Hernández R, Latorre I, Noguera-Julian A, Martínez-Planas A, Minguell L, et al.
Background Diagnosis of nontuberculous mycobacteria (NTM) infections remains a challenge. In this study, we describe the evaluation of an immunological NTM-interferon (IFN)-γ release assay (IGRA) that we developed using glycopeptidolipids (GPLs) as NTM-specific antigens. Methods …
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Vukugah TA, Ntoh VN, Akoku DA, Leonie S, Jacob A
…o meet the specific needs of children is critical to ending pediatric TB epidemic. Systematic reviews are increasingly informing policies in pediatric tuberculosis (TB) care and control. However, there is a paucity of information on pediatric TB research priorities. Methodology .…
Xiaojun Wang, Cuili Yang, Meilan Zhou, Cuiping Xiao, Xiaolu Yu, et al.
**BACKGROUND:** Research on the economic burden of pediatric tuberculosis (TB) remains scarce. This study aims to investigate the hospitalization characteristics, direct medical expenses, and key determinants of hospitalization costs in pediatric TB patients. **METHODS:** We con…
Indumathi CK, Jain S, Krishnamurthy S, Alexander B
…iologically confirmed disease among children diagnosed with tuberculosis using RNTCP guidelines. Materials and methods Retrospective chart review of a cohort of 151 children (aged between 1 month and 18 years) diagnosed with Tuberculosis between December 2016 and June 2020 at a p…
Zhou H, Pei Y, Xie Q, Nie W, Liu X, et al.
… in the lower respiratory tracts of children with pulmonary tuberculosis (PTB). In this study, we assessed the value of mNGS in the pathogen diagnosis and microbiome analysis of PTB patients using bronchoalveolar lavage fluid (BALF) samples. Methods A total of 64 participants, co…
Silla Varghese Thomas, Priya Rajendran, Sivakumar Shanmugam
This review provides an insight into pediatric tuberculosis (TB) diagnosis in India. Significant challenges still exist in the accurate diagnosis of pediatric TB due to the paucibacillary status of the bacilli and the nonspecific clinical symptoms. Despite advancements in newer d…
Mengyue Tong, Wenrui Ding, Hao Wu, Lijiao Yuan, Xin Ma, et al.
**BACKGROUND:** Abdominal tuberculosis (TB) in pediatric patients is a rare but serious condition that can often be misdiagnosed as malignancy or other abdominal disorders. Intestinal perforation is a rare and life-threatening complication that presents significant diagnostic and…
James Marcomic Maragia, Jepchirchir Kiplagat, Onyango Dickens, Lazarus Odeny, Stephen Olubulyera, et al.
**BACKGROUND:** Tuberculosis (TB) remains a significant global public health challenge, with 10.8 million cases and 1.23 million deaths reported in 2023. Children comprised 11% of these cases and deaths globally. In Kenya, approximately 77,000 TB cases were reporte…
Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi TK, Tlhakanelo JT, et al.
…duction Globally, the amount of research on the outcomes of pediatric tuberculosis (TB) is disproportionately less than that of adult TB. The diagnosis of paediatric TB is also problematic in developing countries. The aim of this study was to describe the outcomes of pediatric TB…
Mi Zhou, Xuren Chen, Jie Huang, Runlin Su, Hongmei Lei, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) management remains an underemphasized area plagued by diagnostic and treatment challenges that are compounded further due to rising levels of drug-resistant tuberculosis (DR-TB). Even though TB incidence is high in China, limited data e…