Showing 101–125 of 192 documents
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Qian Lei, Hao Wang, Liyun Dang, Xiaohui Lv, Xuejiao Zhou, et al.
…in (RFP) in drug-susceptible TB patients, and to assess its clinical effectiveness and safety through a pragmatic randomized controlled trial (PRCT). **METHODS:** A total of 489 TB patients undergoing first-line anti-TB treatment were enrolled and randomly assigned to a pha…
Gashu KD, Gelaye KA, Lester R, Tilahun B
… home. Methods We conducted a two-arm randomised controlled trial on adult patients with TB during the continuation phase. In the intervention arm, patients received routine care plus phone-based weekly pill refilling and daily medication reminders. In the control arm, participan…
Bhargava A, Bhargava M, Meher A, Teja GS, Velayutham B, et al.
…ia. RATIONS is a field-based, cluster-randomised controlled trial evaluating the effect of providing nutritional support to household contacts of adult patients with microbiologically confirmed pulmonary tuberculosis in Jharkhand, India, on tuberculosis incidence. The patient coh…
Lifan Zhang, Yujie He, Wenwen Wang, Lijun Wu, Xiaoxia Zuo, et al.
…cted a multicenter, open-label, randomized, non-inferiority trial at nine tertiary general hospitals in China. Eligible participants were adults (18-70 years) with high-risk rheumatic diseases and LTBI undergoing immunosuppressive therapy. Patients were randomized (1:1) to receiv…
Van Hoving DJ, Griesel R, Meintjes G, Takwoingi Y, Maartens G, et al.
…ential sources of heterogeneity in test accuracy, including clinical setting, ultrasound training level, and type of reference standard. Search methods We searched for publications in any language up to 4 April 2019 in the following databases: MEDLINE, Embase, BIOSIS, Science Cit…
Fernández-Ruiz M, Aguado JM
…ndications of available agents are reviewed, as well as the clinical evidence coming from clinical trials and observational registries. We discuss the impact of patient- and disease-related factors influencing the occurrence of infection. Finally, strategies for risk minimization…
Tamuzi JL, Ayele BT, Shumba CS, Adetokunboh OO, Uwimana-Nicol J, et al.
… HIV/TB co-infected or TB patients, screening algorithm and clinical management. Methods We conducted an electronic search of potentially eligible studies published in English in the Cochrane Controlled Register of Trials, PubMed, Medrxiv, Google scholar and Clinical Trials Regis…
Gong X, He Y, Zhou K, Hua Y, Li Y
…ntly improve the accuracy of tuberculosis (TB) detection in clinical settings, with advanced sensitivity and specificity. Early detection of TB can be challenging, but Xpert has improved the efficacy of the diagnostic process. Nevertheless, the accuracy of Xpert varies according …
Amare W Tadesse, Mamush Sahile, Nicola Foster, Christopher Finn McQuaid, Gedion Teferra Weldemichael, et al.
…rrence. **METHODS:** We did a pragmatic cluster-randomised trial in Ethiopia. 78 health facilities (clusters) were randomised (1:1:1) to smart pillbox, medication labels, or standard of care. Adults aged 18 years or older with drug-sensitive pulmonary tuberculosis on a fixed-dos…
Bediang G, Stoll B, Elia N, Abena JL, Geissbuhler A
…between the fifth and the sixth months of treatment. Future trials should focus on reducing the dropout rate. Trial registration The trial was registered on the Pan-African Clinical Trials Registry ( PACTR201307000583416 of 22 July 2013) and the protocol was published.
Manabu Suzuki, Satoki Hatano, Chie Morita, Akinari Tsukada, Akane Ishida, et al.
…ucted a retrospective observational study to understand the clinical characteristics of patients with cryptogenic hemoptysis (CH). **METHODS:** The clinical characteristics, angiographic findings, and immediate and long-term efficacies of BAE were retrospectively analyzed in 36 …
Hirabayashi R, Nakayama H, Yahaba M, Yamanashi H, Kawasaki T
…IGRAs may be useful for detecting TB infection in children. Clinical trial registration The review protocol was prospectively registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000046737).
O'Rourke J, Townsend CL, Milanzi E, Collins IJ, Castro H, et al.
… Methods We searched MEDLINE, Embase, the Cochrane Library, clinical trial registries, reference lists and relevant conferences to identify literature published January 2009-March 2021. We included clinical trials and observational studies assessing the efficacy/effectiveness or …
Crider K, Williams J, Qi YP, Gutman J, Yeung L, et al.
…w Types of studies Inclusion criteria Randomized controlled trials (RCTs) Quasi-RCTs with randomization at the individual or cluster level conducted in malaria-endemic areas (areas with ongoing, local malaria transmission, including areas approaching elimination, as listed in the…
Aisya Rezki Noeriman, Sumarheni Sumarheni, Aliya Nur Hasanah, Lika Apriani, Prayudi Santoso, et al.
…B) treatment remains limited. This scoping review evaluated clinical studies on TDM and its impact on TB treatment outcomes. **METHODS:** A scoping review was performed using a systematic search in PubMed, Embase, Web of Science, ClinicalTrials.gov, and the World Health Organiza…
Fox GJ, Nhung NV, Sy DN, Hoa NLP, Anh LTN, et al.
…tnam. Methods We performed a cluster-randomized, controlled trial at clinics in 70 districts (local government areas with an average population of approximately 500,000 in urban areas and 100,000 in rural areas) in eight provinces of Vietnam. Health workers at each district clini…
Yang Y, Cai J, Wang X, Zhao K, Lei Z, et al.
…We conducted a double-blinded placebo-controlled randomized trial in 360 pulmonary tuberculosis patients with concurrent diabetes or prediabetes. The participants were randomly assigned to receive a daily nutrition package (112 kcal, 9 g protein, and micronutrients) or a daily pl…
Lin H, Lin Y, Zheng Y, Liu Z, Chang C
… to help TB patients quit smoking, and we will evaluate the clinical efficacy of this application by using a randomised controlled trial (RCT). Methods and analysis This is a two-step study. In the first step, we will develop a smartphone application based on an interactive appli…
Cox SR, Kadam A, Atre S, Gupte AN, Sohn H, et al.
…e I effectiveness-implementation non-inferiority randomized trial to compare the effectiveness, cost-effectiveness, and feasibility of two ACF strategies among individuals who have completed TB treatment and their household contacts (HHCs). Methods We will enroll 1076 adults (≥ 1…
Dogar O, Keding A, Gabe R, Marshall AM, Huque R, et al.
…hods We did a randomised, double-blind, placebo-controlled, trial at 32 health centres in Bangladesh and Pakistan. Eligible patients were adults (aged >18 years in Bangladesh; aged >15 years in Pakistan) with pulmonary tuberculosis diagnosed in the previous 4 weeks, who smoked to…
Rittberg R, Leung B, Al-Hashami Z, Ho C
…atment, and survival data were collected through the Cancer Registry. Retrospective chart review was completed to extract past medical history and missing variables. CASPIAN/IMPower133 excluded patients with autoimmune diseases, active infection, and performance status (PS) ≥2. R…
Xiaorui Ruan, Kebin Chen, Ziye Li, Jianhui Wei, Ye Chen, et al.
…tions should be prioritized by antenatal care providers. **TRIAL REGISTRATION:** The study was retrospectively registered in Chinese Clinical Trial Registry Center on 06/14/2018, registration number: ChiCTR1800016635, available at: https://www.chictr.org.cn/showproj.html?proj=28…
Yao Qin, Yuanyuan Chen, Qingshan Cai
…s was a single-arm, prospective, monocentric, observational trial. From June 2020 to January 2023, 29 patients meeting the inclusion criteria were selected from Hangzhou Red Cross Hospital. These patients received a treatment regimen that included Dlm. Data were collected on pati…
Christine Sekaggya-Wiltshire, Eva Agnes Laker Odongpiny, Francis Williams Ojara, Isabella Kyohairwe, Reuben Kiggundu, et al.
…tuberculosis dosing among people living with HIV (PLWH). **CLINICAL REGISTRATION:** The study is registered with Pan African Clinical Trials Registry, registration number PACTR202409710100607, registration date 07 August 2024, pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=31764.
Reza TF, Nalugwa T, Farr K, Nantale M, Oyuku D, et al.
…mance Evaluation for Linkage to Tuberculosis Care (XPEL-TB) trial uses an ultra-pragmatic, hybrid type II effectiveness-implementation design to assess the effectiveness and implementation of a streamlined strategy for delivery of Xpert testing in real-world settings. Twenty heal…