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GBD 2023 Vaccine Coverage Collaborators
…ne coverage; (2) we forecast coverage of select life-course vaccines up to 2030; and (3) we analyse progress needed to reduce the number of zero-dose children by half between 2023 and 2030. **FINDINGS:** Overall, global coverage for the original EPI vaccines against diphtheria, …
Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, et al.
Immunotherapy for cervical cancer should target high-risk human papillomavirus types 16 and 18, which cause 50% and 20% of cervical cancers, respectively. Here, we describe the construction and characterization of the pBI-11 DNA vaccine via the addition of codon-optimized human p…
Cholewik M, Stępień M, Bieńkowski C, Pokorska-Śpiewak M
Background: Russia's aggression against Ukraine in early 2022 resulted in a large migration of refugees to many countries, including Poland. Vaccination coverage for some infectious diseases in Ukraine is lower than in Poland; consequently, the incidence of infectious diseases-in…
Sanami S, Rafieian-Kopaei M, Dehkordi KA, Pazoki-Toroudi H, Azadegan-Dehkordi F, et al.
…ed. There are currently commercially available prophylactic vaccines that have been shown to protect vaccinated individuals against HPV infections, however, these vaccines have no therapeutic effects for those who are previously infected with the virus. The current study's aim wa…
Meskell P, Biesty LM, Dowling M, Roche K, Meehan E, et al.
…ential risks and benefits associated with rapidly developed vaccines. Objectives To explore the factors that influence a person's decision to participate in a vaccine trial in the context of a pandemic or epidemic. Search methods We used standard, extensive Cochrane search method…
Tameris M, Mearns H, Penn-Nicholson A, Gregg Y, Bilek N, et al.
…nd Infants are a key target population for new tuberculosis vaccines. We assessed the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmission of tuberculosis is very high. Methods We…
Hoft SG, Kauffman KD, Sakai S, Lindestam Arlehamn CS, Sette A, et al.
…nding T cells may enhance the airway immunogenicity of oral vaccines.
Folegatti PM, Jenkin D, Morris S, Gilbert S, Kim D, et al.
…2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key features of new platform technology vaccines. This manuscript reviews key features of the ChAdOx1-vectored vaccines. The simian adenovirus …
Prabowo SA, Painter H, Zelmer A, Smith SG, Seifert K, et al.
Tuberculosis (TB) is a major global health problem and there is a dire need for an improved treatment. A strategy to combine vaccination with drug treatment, termed therapeutic vaccination, is expected to provide benefit in shortening treatment duration and augmenting treatment s…
Teljeur C, Moran PS, Harrington P, Butler K, Corcoran B, et al.
Background In Western Europe, currently only Ireland and Portugal continue to provide universal neonatal bacillus Calmette-Guérin (BCG) vaccination programs, despite not being considered as high tuberculosis (TB) incidence countries. Other European countries only vaccinate infant…
Zhuang L, Ye Z, Li L, Yang L, Gong W
…cy, particularly in adults. Efforts to develop effective TB vaccines have been ongoing for nearly a century. In this review, we have examined the current obstacles in TB vaccine research and emphasized the significance of understanding the interaction mechanism between MTB and ho…
Socha A, Klein J
Background Migrant populations in the European Union (EU) suffer a disproportionate burden of infectious diseases and may be particularly vulnerable due to poor conditions in countries of origin or throughout transit to the host country. Given the rising level of migration into E…
Ostermann J, Vasudevan L, Baumgartner JN, Ngadaya E, Mfinanga SG
Background Vaccination is a cost-effective strategy for reducing morbidity and mortality among children under 5 years old. To be fully protected from diseases such as tuberculosis, diphtheria, pertussis, and polio, children must receive all recommended vaccinations in a timely ma…
Bhattacharyya A, Shahabuddin SM
…asles vaccine for children and rubella and adult diphtheria vaccines for pregnant women. We conducted this rapid review on adult immunization relevant for India, as recent COVID-19 experience revealed how newly emergent or re-emergent pathogens could have their onslaughts on the …
Rupali Limaye, Jessica Schue, Berhaun Fesshaye, Prachi Singh, Emily Miller, et al.
… to maternal and neonatal health. For TB and GBS, there are vaccines in various stages of clinical trial development, and malaria and RSV vaccines are available. This study aimed to examine pregnant women's attitudes toward TB, malaria, GBS, and RSV vaccines in Brazil, Ghana, Ken…
Thakur A, Ingvarsson PT, Schmidt ST, Rose F, Andersen P, et al.
Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain fa…
Andrew Robertson, Mark A Chambers, Graham C Smith, Richard J Delahay, Robbie A McDonald, et al.
In parts of Europe, the European badger Meles meles acts as a wildlife host for Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB). Options for reducing the risk of transmission of M. bovis from badgers to cattle include biosecurity measures, culling, and vacci…
Weerasuriya CK, Harris RC, McQuaid CF, Bozzani F, Ruan Y, et al.
…rough the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the epidemiologic impact, cost-effectiveness, and budget impact of hypothetical novel prophylactic p…
Williams GA, Allen D, Brewer J, Salguero FJ, Houghton S, et al.
Bovine tuberculosis (bTB), caused by Mycobacterium bovis infection, is a zoonotic disease in cattle that represents a significant ongoing challenge to cattle farming productivity and the livelihoods of livestock farmers in the UK. Vaccination of cattle with BCG could directly tar…
Brett K, Severn M
… general use, and it is one of the most widely administered vaccines. Nevertheless, there are still some questions with regards to the effectiveness of the BCG vaccine, particularly, the duration of the effect, and the ability to protect against pulmonary TB in adults. A global r…
Hanafy M, Hansen C, Phanse Y, Wu CW, Nelson K, et al.
…conomic losses to the dairy industry. Available inactivated vaccines are not effective in controlling the disease and vaccinated animals can continue to infect newly born calves. Recently, we have shown that a live-attenuated vaccine candidate (pgsN) is protective in goats and ca…
Kaufmann SHE
…e same time, the development of highly efficacious COVID-19 vaccines within less than a year raises hope that this threat can be tamed in the near future. For the last 200 years, the agent of tuberculosis (TB) has been the worst killer amongst all pathogens. Although a vaccine ha…
Andrie EK, Sakellari E, Barbouni A, Tsitsika AK, Lagiou A
…vaccinated. This coverage was lower in males especially for vaccines that should be done during childhood (p = 0.045). High vaccination percentage (>90%) was observed for the meningococcus group A, C, W135, Y, measles-mumps-rubella, hepatitis B and meningitis C vaccine. Neverthel…
Lidia Del Pozo-Ramos, Andreas Kupz
Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, causing over a million deaths annually. The only licensed TB vaccine for human use, Bacille Calmette-Guérin (BCG), a mycobacteria-based live-attenuated vaccine, confers immunity to children but fai…
Gerste AK, Majidulla A, Baidya A, Georgewill O, DeLuca AN, et al.
Introduction The historical focus of vaccines on child health coupled with the advent of novel vaccines targeting adult populations necessitates exploring strategies for adult vaccine implementation. Areas covered This scoping review extracts insights from the past decade's exper…