Showing 101–125 of 200 documents
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Nguyen QH, Contamin L, Nguyen TVA, Bañuls AL
At present, the successful transmission of drug-resistant Mycobacterium tuberculosis , including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, in human populations, threatens tuberculosis control worldwide. Differently from many other bacteria, M. tuberc…
Khaoula Balgouthi, Emel Eker, Manaf AlMatar, Osman Albarri, Işil Var
Anti-tuberculosis activity and resistance were recently refocused since clofazimine (CFZ) had a significant therapeutic benefit in treating multi-drug resistant tuberculosis (MDR-TB). We investigate the resistance of CFZ and genetic mutations in drug-resistant Mycobacterium tuber…
Maladan Y, Krismawati H, Wahyuni T, Tanjung R, Awaludin K, et al.
…ll becomes a burden for many countries including Indonesia. Drug resistance is one of the problems in TB treatment. However, a development in the molecular field through Whole-genome sequencing (WGS) can be used as a solution in detecting mutations associated with TB- drugs. This…
Tang C, Wu L, Li M, Dai J, Shi Y, et al.
Drug-resistant tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), is one of the urgent clinical problems and public health challenges. Culture-based phenotypic drug susceptibility testing (pDST) is time-co…
Zhang X, Lam C, Martinez E, Sim E, Crighton T, et al.
…f Mycobacterium tuberculosis harboring mutations conferring resistance can become dominant populations during tuberculosis (TB) treatment, leading to treatment failure. Our understanding of drug-resistant within-host subpopulations and the frequency of resistance-conferring mutat…
A Stoltz, R R Nathavitharana, E de Kock, V Ueckermann, P Jensen, et al.
**BACKGROUND:** Most drug-resistant tuberculosis occurs due to transmission of unsuspected or ineffectively treated drug-resistant tuberculosis. The duration of treatment to stop person-to-person spread of drug-resistant tuberculosis is uncertain. We evaluated the impact of novel…
Yadav M, Jain AK, Singhal R, Chadha M, Arora VK, et al.
…ground There is paucity of data on incidence and pattern of drug resistance in spinal TB. This prospective observational study was conducted to document the incidence and drug-resistance pattern among primary and presumptive resistant cases. Methods 59 consecutive cases diagnosed…
Habous M, Elimam M, AlDabal L, Chidambaran B, AlDeesi Z
…und The objective of this study is to determine the initial drug resistance pattern among new tuberculosis (TB) cases and assess the extent of association with human immunodeficiency virus (HIV) and diabetes mellitus (DM). Method This is a retrospective analysis of 1116 clinical …
Araújo LG, Garcia MT, Zaccariotto TR, Moretti ML, Levy CE, et al.
Multidrug-resistant tuberculosis (MDR-TB) represents a significant impact in transmission, outcome, and health costs. The World Health Organization recommends implementation of rapid diagnostic methods for multidrug-resistance detection. This study was performed to evaluate the f…
Miotto P, Zhang Y, Cirillo DM, Yam WC
…associated global threat has worsened with the emergence of drug resistance, in particular multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). Although the World Health Organization (WHO) End-TB Strategy advocates for universal access to antimicrobial susc…
Yang JS, Kim KJ, Choi H, Lee SH
…zolid have recently been approved for the treatment of multidrug- and extensively drug-resistant (MDR and XDR, respectively) tuberculosis (TB). To use these drugs effectively, drug susceptibility tests, including rapid molecular techniques, are required for accurate diagnosis and…
Hilina Mollalign, Dawit Hailu Alemayehu, Kalkidan Melaku, Abaysew Ayele, Dawit Chala, et al.
Globally, drug-resistant tuberculosis (DR-TB) is responsible for 13% of mortality attributable to antimicrobial resistance. In Ethiopia, extrapulmonary tuberculosis (EPTB) is a significant public health challenge, and drug resistance (DR) in EPTB is often overlooked. In a cross-s…
Mesfin EA, Beyene D, Tesfaye A, Admasu A, Addise D, et al.
Background Multidrug drug-resistant tuberculosis (MDR-TB) is a major health problem and seriously threatens TB control and prevention efforts globally. Ethiopia is among the 30th highest TB burden countries for MDR-TB with 14% prevalence among previously treated cases. The focus …
Bisrat Solomon, Yimtubezinash Woldeamanuel, Tigest Ajeme, Mbazi Senkoro, Tsegahun Manyazewal
**BACKGROUND:** Drug-resistant tuberculosis poses a major global public health threat, with adverse drug reactions complicating treatment and contributing to mortality. In Ethiopia, although many patients with drug-resistant tuberculosis are receiving treatment, studies on advers…
Jiang Z, Lu Y, Liu Z, Wu W, Xu X, et al.
Prediction of antimicrobial resistance based on whole-genome sequencing data has attracted greater attention due to its rapidity and convenience. Numerous machine learning-based studies have used genetic variants to predict drug resistance in Mycobacterium tuberculosis (MTB), ass…
Verma H, Nagar S, Vohra S, Pandey S, Lal D, et al.
…nfects millions of people worldwide. The emergence of multi-drug resistant (MDR), extensively drug resistant (XDR) and totally drug resistant (TDR) M. tuberculosis strains against the first- and second-line anti-TB drugs has created an urgent need for the development and implemen…
Dadu A, Hovhannesyan A, Ahmedov S, van der Werf MJ, Dara M
…ions, the WHO European Region has the highest proportion of drug-resistant tuberculosis among new and retreated cases. The 18 high-priority countries in eastern Europe and central Asia account for 85% of the tuberculosis incidence and more than 90% of drug-resistant tuberculosis …
Mortimer TD, Weber AM, Pepperell CS
…nd global TB control efforts are increasingly threatened by drug resistance in Mycobacterium tuberculosis . Unlike most bacteria, where lateral gene transfer is an important mechanism of resistance acquisition, resistant M. tuberculosis arises solely by de novo chromosomal mutati…
Getu Diriba, Ayinalem Alemu, Bazezew Yenew, Betselot Zerihun Ayano, Michael Hailu, et al.
…To estimate the proportion of second-line anti-tuberculosis drug resistance among multidrug-resistant tuberculosis (MDR-TB) patients in Ethiopia. **METHODOLOGY:** A laboratory-based prospective cross-sectional study was conducted at the National Tuberculosis Reference Laboratory…
Margineanu I, Butnaru T, Lam M, Baiceanu D, Dragomir R, et al.
Background Tuberculosis (TB), and especially its drug resistant forms, is responsible for not only significant mortality, but also considerable morbidity, still under-quantified. This study used four Patient-Reported Outcome Measures (PROMS) to assess the status of persons affect…
Nimmo C, Millard J, van Dorp L, Brien K, Moodley S, et al.
Background Bedaquiline and clofazimine are important drugs in the treatment of drug-resistant tuberculosis and are commonly used across southern Africa, although drug susceptibility testing is not routinely performed. In this study, we did a genotypic and phenotypic analysis of d…
Zhao LL, Li MC, Liu HC, Xiao TY, Li GL, et al.
…ciation between Beijing genotype and the characteristics of drug resistance. In this study, 359 M. tuberculosis isolates from south China were collected and their background information, genotype diversity and drug resistance was investigated. The results revealed that 66.0% of s…
Chen X, He G, Wang S, Lin S, Chen J, et al.
[This corrects the article DOI: 10.3389/fmicb.2019.01741.].
Cheng N, Wu S, Luo X, Xu C, Lou Q, et al.
Purpose To investigate the CT features of drug-resistant pulmonary tuberculosis (DR-PTB) and the diagnostic value of CT in DR-PTB diagnosis to provide imaging evidence for the timely detection of drug-resistant Mycobacterium tuberculosis . Materials and methods A total of 1546 ca…
Tembo BP, Malangu NG
…evalence and factors associated with the prevalence of multidrug/rifampicin-resistant tuberculosis among suspected drug resistant tuberculosis patients in Botswana. Methods A retrospective review of medical records of suspected drug resistant tuberculosis patients receiving care …