Showing 101–125 of 200 documents
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Steven G Smith, Ruth Bowness, Jacqueline M Cliff
Host-directed therapy could potentially revolutionize tuberculosis control as an adjunct to traditional antibiotics for the treatment of tuberculosis disease and as a strategy to prevent disease progression following Mycobacterium tuberculosis infection. The growing type 2 diabet…
Saha A, Escuduero J, Layouni T, Richardson B, Hou S, et al.
…ound Pregnancy is a risk factor for progression from latent tuberculosis infection to symptomatic tuberculosis. However, how pregnancy influences T-cell responses to Mycobacterium tuberculosis is unknown. Methods We measured M. tuberculosis-specific cytokines, T-cell memory marke…
Pelzer PT, Stuck L, Martinez L, Richards AS, Acuña-Villaorduña C, et al.
Background Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectivenes…
Meiwes L, Kontsevaya I, Chesov D, Kulciţkaia S, Dreyer V, et al.
…ce mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA…
Barham MS, Whatney WE, Khayumbi J, Ongalo J, Sasser LE, et al.
…ficant risk factor for reactivation of latent Mycobacterium tuberculosis infection (LTBI) and progression to active tuberculosis disease, yet the mechanisms whereby HIV impairs T cell immunity to M. tuberculosis have not been fully defined. Evaluation of M. tuberculosis -specific…
Shivangi Sinhal, Geetika Srivastava, Shrish Bhatnagar, Nanda Chhavi, Digvijay Chaudhary, et al.
…ection is highly prevalent in our country and conversion to tuberculosis disease is a major concern. Under the National Strategic Plan, India is heading towards ending tuberculosis by 2025. The benefits of tuberculosis preventive therapy are being extended to the children aged &#…
Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC, et al.
…ociated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti-tuberculosis medications modify this risk are unclear. Our objective was to evaluate how use of these treatments altered mo…
Seid G, Alemu A, Dagne B, Sinshaw W, Gumi B
Background The Mycobacterium tuberculosis complex causes tuberculosis, a severe public health problem. Close contacts of someone who has active pulmonary tuberculosis were at a greater risk of contracting the disease. Despite the large number of primary research available in Sub-…
Honjo K, Komiya K, Kan T, Uchida S, Goto A, et al.
…e advanced age is a main prognostic factor in patients with tuberculosis, the factors that specifically affect tuberculosis-related death are unclear because elderly people are at a risk for other age-related lethal diseases. We aimed to assess the impact of performance status on…
Leyla Larsson, Ioana Diana Olaru, Anna-Lisa Behnke, Edson T Marambire, Martha Chipinduro, et al.
**BACKGROUND:** Tuberculosis elimination is constrained by symptom-based and sputum-dependent diagnostic strategies, which miss asymptomatic disease and are difficult to deploy in community settings. Household contacts of people with tuberculosis are a priority population for scr…
Harirzadeh S, Kazemi MJ, Babakhani S
Introduction: Mycobacterium tuberculosis is the cause of pulmonary and extra-pulmonary tuberculosis. Latent tuberculosis is asymptomatic and the results of mycobacterial culture in this case are negative. The purpose of this study was to determine the prevalence of M. tuberculosi…
Ayenew Berhan, Bekele Sharew, Andargachew Almaw, Shewaneh Damtie, Biruk Legese, et al.
**BACKGROUND AND AIMS:** Tuberculosis is a major infectious disease that affects hematological profiles. However, limited data assess changes in hematological profiles among patients with pulmonary and multidrug-resistant tuberculosis. Therefore, this study aimed to compare the h…
Xu-Wen Fu, Yan Bi, Min Qi, Jing-Liang Liu, Jia-Lu Wei, et al.
…m of this study is to enhance the understanding of prostate tuberculosis by analyzing clinical data and prostate computed tomography (CT) imaging of patients with hematogenous disseminated pulmonary tuberculosis and prostate tuberculosis. **METHODS:** Patients with hematogenous …
Warria K, Nyamthimba P, Chweya A, Agaya J, Achola M, et al.
Objective To compare the prevalence of tuberculosis infection and disease in household contacts of patients with bacteriologically confirmed tuberculosis disease and contacts of non-bacteriologically confirmed disease in western Kenya. Methods We enrolled newly diagnosed index pa…
Avkan-Oğuz V, Öner-Eyüboğlu F, Turunç T, Ersöz G, Tezer-Tekçe Y, et al.
Objectives Tuberculosis risk in solid-organ transplant recipients is more than the general population, although tuberculosis incidence has been reported to decrease 5% in the last decade in Turkey. In Turkey, solid-organ transplants started in 1975; however, routine pretransplant…
Adane A, Damena M, Weldegebreal F, Mohammed H
Background Tuberculosis is an infectious airborne disease caused by Mycobacterium tuberculosis . It still remains a major public health problem which affects all age groups. Risk of exposure is higher in household contact than members of the general population. Objective The aim …
Hyun J, Lee M, Jung I, Kim E, Hahn SM, et al.
…cipients are immunocompromised and vulnerable to developing tuberculosis. However, active tuberculosis incidence is rapidly declining in South Korea, but the trend of tuberculosis infection among transplant recipients has not been elucidated. This study aimed to evaluate the risk…
Yoon Y, Seo H, Kim S, Lee Y, Rahim MA, et al.
Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis . It affects about 10 million people each year and is still one of the leading causes of death worldwide. About 2 to 3 billion people (equivalent to 1 in 3 people in the world) are infected with late…
Igwaran A, Edoamodu CE
Tuberculosis is one of the oldest known diseases and the leading communicable cause of deaths worldwide. Although several studies have been carried out on tuberculosis, no research has examined the publication trends in this area. Hence, this study aimed to fill the gap by conduc…
Liu L, Wang X, Luo L, Liu X, Chen J
Background Tuberculosis destroyed lung constitutes a significant worldwide public health challenge, little is known about its associated risk factors and prognosis. Our study aimed to identify the risk factors of tuberculosis destroyed lung among pulmonary tuberculosis and struct…
Tierney DB, Orvis E, Nathavitharana RR, Hurwitz S, Tintaya K, et al.
…ly, Separate safely, Treat effectively) strategy on time to tuberculosis diagnosis and treatment for patients at a general hospital in a tuberculosis-endemic setting. Design Prospective cohort study with historical controls. Participants Patients diagnosed with pulmonary tubercul…
Sinha M, Rani R, Bagga P
Objectives To analyse correlation of past history of tuberculosis with present state of infertility with respect to HSG and diagnostic findings, with a view to assess the frequency of genital tuberculosis in infertile women, its clinical presentation and association with infertil…
Merid Y, Hailu E, Habtamu G, Tilahun M, Abebe M, et al.
Introduction Understanding the epidemiology of tuberculosis is limited by lack of genotyping data. We sought to characterize the drug susceptibility testing patterns and genetic diversity of M. tuberculosis isolates in southern Ethiopia. Methodology A cross-sectional study was co…
Seo H, Yoon Y, Kim S, Ghorbanian F, Tajdozian H, et al.
Background Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis, and the increase in antibiotic resistance threatens humankind. Therefore, there is an urgent need to develop new anti-tuberculosis drugs that can overcome the limitations of existing drug…
Chen H, Zhou J, Zhao X, Liu Q, Shao L, et al.
… role of soluble immune checkpoints (sICs) in Mycobacterium tuberculosis (M. tb) infection remains unknown. We assessed the levels of multiple sICs in individuals with distinct M. tb infection status, and their dynamic changes during anti-tuberculosis treatment. Methods We enroll…