Showing 76–100 of 200 documents
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Desai U, Joshi JM
Background Drug-resistant tuberculosis (DR-TB) is a global problem with only 52% reported cure rate. Extrapulmonary (EP) DR-TB poses a formidable diagnostic, therapeutic challenge. We aimed to study their clinical profile and treatment outcomes under the programmatic setting. Mat…
Keikha M, Majidzadeh M
We found that the frequency of Beijing genotype among XDR-TB strains was high. The data in this study would help guide the TB control program, and we however need further investigation to confirm the reliability of the present findings.
Ismail NA, Mvusi L, Nanoo A, Dreyer A, Omar SV, et al.
…tionately high number of cases of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We sought to estimate the prevalence of resistance to tuberculosis drugs in newly diagnosed and retreated patients with tuberculosis provincially and nation…
Yaşar Durmuş S, Tanır G, Aydın Teke T, Kaman A, Yalçınkaya R, et al.
Background Smear-positive adults with tuberculosis are the main source of childhood tuberculosis. The evaluation of children exposed to tuberculosis and determination of the disease stages are the cornerstones of managing childhood tuberculosis. Aim To determine the frequency of …
Schnippel K, Ndjeka N, Maartens G, Meintjes G, Master I, et al.
…ddition of bedaquiline to treatment for multidrug-resistant tuberculosis was associated with an increased risk of death in a phase 2b clinical trial, resulting in caution from WHO. Following a compassionate access programme and local regulatory approval, the South African Nationa…
Zhang A, Jumbe E, Krysiak R, Sidiki S, Kelley HV, et al.
Background Rural settings where molecular tuberculosis diagnostics are not currently available need easy-to-use tests that do not require additional processing or equipment. While acid-fast bacilli (AFB) smear is the most common and often only tuberculosis diagnosis test performe…
Abay GK, Abraha BH
Background Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis pose a considerable challenge to tuberculosis control pro…
Chen Yang, Guangchuan Dai, Yicheng Guo, Tianzhen Wang, Weiwei Gao, et al.
**BACKGROUND:** Drug-resistant tuberculosis has emerged as a major public health issue that requires immediate attention. NTS is an innovative method that allows for the direct detection of clinical samples without the need for culture. It could provide more accurate, reliable, a…
Jingxian Ning, Rong Wang, Yuchen Pan, Xinru Fei, Wenxin Jiang, et al.
**OBJECTIVE:** Tuberculosis significantly affects human health and longevity. We aimed to systematically synthesize studies to summarize the median survival time range and years of potential life lost (YPLL) among tuberculosis patients. **METHODS:** We searched Web of Science, P…
Amin A, Vartanian A, Yegiazaryan A, Al-Kassir AL, Venketaraman V
Tuberculosis disease is caused by the bacterium Mycobacterium tuberculosis . It is estimated that 10 million people have developed tuberculosis disease globally, leading to 1.4 million deaths in 2019. Treatment of tuberculosis has been especially challenging due to the rise of mu…
Natarajan A, Beena PM, Devnikar AV, Mali S
Tuberculosis (TB), which is caused by bacteria of the Mycobacterium tuberculosis complex, is one of the oldest diseases known to affect humans and a major cause of death worldwide. Tuberculosis continues to be a huge peril disease against the human population and according to WHO…
Mizukoshi F, Kobayashi N, Kirikae F, Ohta K, Tsuyuguchi K, et al.
…stant (isoniazid and/or rifampicin-resistant) Mycobacterium tuberculosis were obtained from 254 patients diagnosed with drug-resistant tuberculosis in Japan from April 2015 to March 2017 in National Hospital Organization hospitals. The 254 patients were approximately 32% of all 7…
Zürcher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, et al.
Background Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and whole-genome sequencing (…
Nimmo C, Millard J, van Dorp L, Brien K, Moodley S, et al.
…mine are important drugs in the treatment of drug-resistant tuberculosis and are commonly used across southern Africa, although drug susceptibility testing is not routinely performed. In this study, we did a genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberc…
Afsaneh Kaffash, Saeideh Sadat Shobeiri, Elham Pouraslan, Asghar Kazemzadeh, Fatemeh Doost Mohammadi, et al.
…** This ecological study examines epidemiological trends in tuberculosis, multidrug-resistant TB, extensively drug-resistant TB, and latent TB infection across Iran and its provinces from 1990 to 2021, and explores their association with the Human Development Index. **METHODS:**…
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, et al.
Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/ morbidity globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant proportion of human population. The increasing burden of tuberculosis is mainly caused due to…
Jain P, Garing S, Verma D, Saranathan R, Clute-Reinig N, et al.
Phenotypic testing for drug susceptibility of Mycobacterium tuberculosis is critical to basic research and managing the evolving problem of antimicrobial resistance in tuberculosis management, but it remains a specialized technique to which access is severely limited. Here, we re…
O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, et al.
A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency Mycobacterium tuberculosis drug resistance. We assessed a reporter mycobacteriophage (Φ 2…
Deshpande D, Srivastava S, Bendet P, Martin KR, Cirrincione KN, et al.
…monstrated that benzylpenicillin did not kill Mycobacterium tuberculosis In this study, we found that >64 mg/liter of static benzylpenicillin concentrations killed 1.16 to 1.43 log 10 CFU/ml below starting inoculum of extracellular and intracellular M. tuberculosis over 7 days. W…
Zürcher K, Ballif M, Fenner L, Borrell S, Keller PM, et al.
…nd Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory…
Ismail N, Ismail F, Omar SV, Blows L, Gardee Y, et al.
… Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. Objective We sought to review the current status of drug resistant tuberculosis in Africa and highlight key areas requiring imp…
Heidary M, Zaker Bostanabad S, Amini SM, Jafari A, Ghalami Nobar M, et al.
Background Nowadays, tuberculosis (TB) is one of the top ten leading causes of mortality worldwide. The emergence of multidrug-resistant (MDR) - and extensively drug-resistant (XDR) - Mycobacterium tuberculosis (M. tuberculosis) is identified as one of the most challenging threat…
Linnemann LC, Schaible UE, Dallenga TK
Due to the rise of tuberculosis cases infected with multi and extensively drug-resistant Mycobacterium tuberculosis strains and the emergence of isolates resistant to antibiotics newly in clinical use, host-directed therapies targeting pathogenesis-associated immune pathways adju…
Youngkyoung Lee, Hoonhee Seo, Soyeon Lee, Dongsic Choi, Sukyung Kim, et al.
Tuberculosis remains a severe global health threat, exacerbated by the rising prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis. Despite the urgent need for effective interventions, the development of anti-tuberculosis drugs h…
Daniyarov A, Akhmetova A, Rakhimova S, Abilova Z, Yerezhepov D, et al.
…kground Kazakhstan has a high burden of multidrug-resistant tuberculosis in the Central Asian region. This study aimed to perform genomic characterization of Mycobacterium tuberculosis strains obtained from Kazakhstani patients with pre-extensively drug-resistant tuberculosis dia…