Showing 76–100 of 200 documents
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Noubiap JJ, Nansseu JR, Nyaga UF, Nkeck JR, Endomba FT, et al.
…d poor glycaemic control significantly increase the risk of tuberculosis and adversely affect tuberculosis treatment outcomes, the global burden of diabetes in the context of tuberculosis remains unknown. We did a systematic review and meta-analysis to estimate the prevalence of …
Martini M, Gazzaniga V, Behzadifar M, Bragazzi NL, Barberis I
… the most frequently prescribed remedy for the treatment of tuberculosis was a stay in a temperate climate. From the middle of the 19th century to the middle of the 20th, Europe saw the development of sanatoria, where patients were able to benefit from outdoor walks, physical exe…
López-González JA, Martínez-Soto JM, Avila-Cervantes C, Mata-Pineda AL, Álvarez-Hernández G, et al.
…s mellitus (DM) is a common comorbidity of active pulmonary tuberculosis (APTB) that increases the risk of treatment failure during anti-tuberculosis chemotherapy. Evaluating systemic inflammatory response could help determine differences in response to treatment between APTB pat…
Araya S, Negesso AE, Tamir Z
Background Drug-resistant tuberculosis remains a major public health threat complicating tuberculosis control programs globally. Data on rifampicin resistance (RR), which is a surrogate marker for multidrug resistance, are limited among Ethiopian tuberculosis patients. This study…
Musiimenta A, Tumuhimbise W, Atukunda E, Mugaba A, Linnemayr S, et al.
…ies (DATs), such as real-time monitors and SMS reminders in tuberculosis medication adherence, suboptimal patient engagement with various DATs has been reported. Additionally, financial constraints can limit DAT's utility. The perceived usefulness and the design mechanisms of DAT…
Owusu DO, Adankwah E, Aniagyei W, Acheampong I, Minadzi D, et al.
… after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing severe clinical manifestations of tuberculosis, but BCG vaccination effects on the induction of IFN-γ after…
Kentaro Kasuga, Miyako Kitazono, Masaomi Maeda, Taro Koba, Shuichi Matsuda, et al.
Female genital tuberculosis is a rare and often asymptomatic condition, which makes its diagnosis challenging. Early recognition of uncommon clinical presentation of tuberculosis is crucial for the better management of it. We report herein a case of genital tuberculosis that init…
Jiang G, Qin W, Du X, Zhang Y, Zhang M, et al.
Background Anti-tuberculosis drug concentrations are critical for the treatment of spinal tuberculosis. The distribution pattern of anti-tuberculosis drugs between the blood and the vertebral focus needs to be further explored. Methods A total of 31 spinal tuberculosis patients w…
Umayorubhagom A, Baliga SS
Background Tuberculosis disease epidemiology is closely related to social and economic conditions which make its prevention, control and cure challenging. Early diagnosis and adequate treatment will help to prevent various tuberculosis related morbidities. Factors such as adverse…
Musisi E, Wamutu S, Ssengooba W, Kasiinga S, Sessolo A, et al.
Background In 2018, the tuberculosis molecular bacterial load assay (TB-MBLA), a ribosomal RNA-based test, was acknowledged by WHO as a molecular assay that could replace smear microscopy and culture for monitoring tuberculosis treatment response. In this study, we evaluated the …
Boloko L, Schutz C, Sibiya N, Balfour A, Ward A, et al.
Background Mycobacterium tuberculosis bloodstream infection is a leading cause of death in people living with HIV and disseminated bacillary load might be a key driver of disease severity. We aimed to assess Xpert MTB/RIF Ultra (Xpert Ultra) testing of blood as a diagnostic for M…
Tarekegn BG, Tientcheu LD, Decker J, Bell AJ, Mukamolova GV, et al.
Background High proportions of Mycobacterium tuberculosis cells in sputum containing triacylglycerol-rich lipid bodies have been shown to be associated with treatment failure or relapse following antituberculous chemotherapy. Although lipid body determination is a potential bioma…
Muflihah H, Flórido M, Lin LCW, Xia Y, Triccas JA, et al.
…t protection against pulmonary infection with Mycobacterium tuberculosis. Immunity induced by subcutaneous immunization with BCG wanes and does not promote early recruitment of T cell to the lungs after M. tuberculosis infection. Delivery of Tuberculosis (TB) vaccines to the lung…
Abhishek S, Ryndak MB, Choudhary A, Sharma S, Gupta A, et al.
Background Studies on human intraocular tuberculosis (IOTB) are extremely challenging. For understanding the pathogenesis of IOTB, it is important to investigate the mycobacterial transcriptional changes in ocular environment. Methods Mice were challenged intravenously with Mycob…
Nieuwenhuizen NE, Nouailles G, Sutherland JS, Zyla J, Pasternack AH, et al.
…ases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoidosis. Serum activin A levels were increased in TB patients compared to healthy controls, including those with positive tuberculin skin tests, an…
Ronge L, Sloot R, Du Preez K, Kay AW, Kirchner HL, et al.
…ween quantitative IFNγ response and degree of Mycobacterium tuberculosis exposure, infection and tuberculosis (TB) disease status in children. Methods We completed cross-sectional analysis of children (≤15 years) exposed to an adult with bacteriologically confirmed TB, 2007-2012 …
Wang W, Liu A, Liu X, You N, Wang Z, et al.
Substantial tuberculosis transmission occurs outside of households, and tuberculosis surveillance in schools has recently been proposed. However, the yield of tuberculosis outcomes from school contacts is not well characterized. We assessed the prevalence of Mycobacterium tubercu…
Robert Akpata, Jean-Baptiste Ntakpe, Eugène Messou, Nathalie De Castro, Corine Chazallon, et al.
**BACKGROUND:** Tuberculosis is a severe disease, not only due to its lethality but also to a significant morbidity occurring in people living with HIV (PLWH). If factors associated to mortality, severe morbidity and unsuccessful treatment related to the host are well identified …
Robi DT, Teklemariam T, Gebreyes BG, Bogale A, Haile T, et al.
Bovine tuberculosis, caused by Mycobacterium bovis , is a chronic zoonotic disease that persists in Ethiopia despite global control efforts, impacting public health and the economy. However, little is known about the epidemiology of bovine tuberculosis in Southwest Ethiopia. This…
Ge HB, Zhu J
…inical efficacy of Baihe Gujin decoction combined with anti-tuberculosis therapy in mitigating the symptoms of pulmonary tuberculosis and to measure the effect on the CD4+ CD25+ regulatory T cell (T reg ) ratio. Methods This randomized study enrolled patients with pulmonary tuber…
Teixeira LAA, Santos B, Correia MG, Valiquette C, Bastos ML, et al.
Background The duration of the protective effect of tuberculosis preventive therapy (TPT) is controversial. Some studies have found that the protective effect of TPT is lost after cessation of therapy among people with human immunodeficiency virus (HIV) in settings with very high…
Kim J, Keshavjee S, Atun R
Background Tuberculosis (TB) is a major global health burden, which has been inadequately addressed. This study aims to analyze different patterns and gaps of care along the care cascade across countries and to develop a model to examine the relationship between performance of tu…
Shuyin Qian, Xiangyun Wang, Bei Huang, Haiyan Lu, Cuicui Xu, et al.
…n latent categories of stigma among patients with pulmonary tuberculosis over time and their correlation with treatment adherence. **METHODS:** A total of 236 patients with pulmonary tuberculosis were selected as the research subjects using the convenience sampling method. The s…
Qiao YJ, Song XY, Zhang LD, Li F, Zhang HQ, et al.
Background Tuberculosis is among the most devastating infectious diseases worldwide. Spinal tuberculosis is not easy to detect at an early stage, which without effective treatment often leads to spinal deformity and spinal cord damage which in turn cause complications such as par…
Khan AF, Sajjad A, Mian DA, Tariq MM, Jadoon UK, et al.
Background The occurrence of both tuberculosis (TB) and concomitant hepatitis B virus (HBV) is likely to be associated with poor patient outcomes and poor treatment response. Objective To assess whether tuberculosis patients with concomitant hepatitis B virus infection were prone…