Showing 76–100 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Merid MW, Gezie LD, Kassa GM, Muluneh AG, Akalu TY, et al.
Background Second line anti-tuberculosis drugs are substantially complex, long term, more costly, and more toxic than first line anti-tuberculosis drugs. In Ethiopia, evidence on the incidence and predictors of adverse drug events has been limited. Thus, this study aimed at asses…
de Sousa NF, de Freitas MEG, Sidrônio MGS, Souza HD, Czeczot A, et al.
…inhibited the growth of laboratory strains of Mycobacterium tuberculosis with MIC values ranging from 10 to 20 µM. Importantly, three derivatives were active against two multi-drug-resistant clinical isolates of M. tuberculosis with MIC values similar to pan-sensitive strains. In…
Sichen L, Rui W, Yue Y, Xin L, Youbin C, et al.
…udy is to determine the drug resistance status of pulmonary tuberculosis patients in Jilin Province. Methods: A retrospective survey was conducted on 395 sputum culture TB-positive patients admitted to the tuberculosis hospital in Jilin Province in 2019. Sputum samples were cultu…
Dong-Mei Wang, Qi An, Qing Yang, Yi Liao
…e the demographic and clinical characteristics of pediatric tuberculosis (TB) inpatients diagnosed with resistance to any anti-tuberculosis drug [drug-resistant tuberculosis (DR-TB)] in southwest China. **METHODS:** Patients aged ≤14 years with clinically diagnosed…
Herikurniawan Herikurniawan, Joanna Audrey, Mira Yulianti, Ni Nyoman Indira, Cleopas Martin Rumende
Tuberculosis (TB) has become one of the global burdens of disease, with increasing morbidity and mortality every year. Tuberculosis can affect not only the lungs but also the extrapulmonary organs. The prevalence of drug-resistant tuberculosis (DR-TB) is rising and has caused a h…
Herikurniawan H, Audrey J, Yulianti M, Indira NN, Rumende CM
Tuberculosis (TB) has become one of the global burdens of disease, with increasing morbidity and mortality every year. Tuberculosis can affect not only the lungs but also the extrapulmonary organs. The prevalence of drug-resistant tuberculosis (DR-TB) is rising and has caused a h…
Tavanaee Sani A, Ashna H, Kaffash A, Khaledi A, Ghazvini K
… the most important drugs in the treatment of Mycobacterium tuberculosis is caused by mutations in the 81-base pair region of the rpoB gene encoding the β-subunit of RNA polymerase. This study aimed to characterize the mutations in the rpoB gene associated with rifampin resistanc…
Lin WH, Lee WT, Tsai HY, Jou R
… testing (gDST) and phenotypic DST (pDST) for Mycobacterium tuberculosis isolates with disputed (discordance between gDST and pDST results) mutations affect rifampin (RIF)-resistant (RR) and multidrug-resistant (MDR) tuberculosis (TB) treatments due to a lack of practical clinica…
Getachew Seid, Ayinalem Alemu, Getu Diriba, Betselot Zerihun, Gemechu Tadesse, et al.
**BACKGROUND:** There is a gap between tuberculosis (TB) infection and the onset of clinical TB disease, which makes identifying TB transmission dynamics a prominent challenge. Different reports were made on the concordance of drug-resistance profiles between the household contac…
Jingyi Dai, Qiujing Li, Jie Chen, Pei Zhang, Jun Zhao, et al.
**BACKGROUND:** Drug-resistant tuberculosis (TB) pose a significant impact on public health challenge in China. This study aimed to characterize the drug resistance patterns among TB patients at a designated tuberculosis hospital of Yunnan province over the past decade and identi…
Tilahun M, Ameni G, Desta K, Zewude A, Yamuah L, et al.
Introduction Tuberculosis (TB) is caused by M. tuberculosis complex and remains a major global public health problem. The epidemic remains a threat to sub-Saharan Africa, including Ethiopia, with further emergence of drug resistant TB. We investigated the drug sensitivity pattern…
Bargaje M, Bharaswadkar S, Lohidasan S, Panda BK
…ncentrations as an independent risk factor for unfavourable tuberculosis (TB) outcome. With introduction of daily regimen using fixed dose combinations (FDC) under National Tuberculosis Elimination Programme (NTEP) the existence of suboptimal plasma levels of first-line antituber…
Susan E Purchase, Joanna Brigden, James A Seddon, Neil A Martinson, Lee Fairlie, et al.
…BACKGROUND:** Young children have a high risk of developing tuberculosis (TB) disease following infection with Mycobacterium tuberculosis in the absence of preventive treatment. Infection prevalence and risk factors for infection impact delivery of prevention strategies. We aimed…
Stosic M, Vukovic D, Babic D, Antonijevic G, Foley KL, et al.
Background Multidrug resistant (MDR) tuberculosis (TB) represents TB which is simultaneous resistant to at least rifampicin (R) and isoniazid (H). Identifying inadequate therapy as the main cause of this form of the disease and explaining the factors leading to its occurrence, nu…
Yazısız H, Hırçın Cenger D, Yazısız V, Kılıç L, Altın S
Introduction Tuberculosis (TB) is continuing to be a important public health problem in the undeveloped countries. Drug sensitivity rate should be monitored for the effective treatment and control in the TB. The aim of this study was to determine the rate of resistance to first l…
Prommi A, Wongjarit K, Petsong S, Somsukpiroh U, Faksri K, et al.
Isoniazid-resistant tuberculosis (Hr-TB) is an important drug-resistant tuberculosis (TB). In addition to rifampicin, resistance to other medications for Hr-TB can impact the course of treatment; however, there are currently limited data in the literature. In this study, the drug…
Batool R, Khan SW, Imran M, Barry Z, Ali SZ
…e To determine the treatment outcomes of the drug-resistant tuberculosis patients who were previously exposed to second line drugs. Methods The retrospective study was conducted at eight Programmatic Management of Drug Resistant Tuberculosis (PMDT) sites in Sindh and Balochistan.…
Alagappan C, Sunil Shivekar S, Brammacharry U, Cuppusamy Kapalamurthy VR, Sakkaravarthy A, et al.
…s associated with INH resistance mutations in Mycobacterium tuberculosis in codon katG315 and in the promoter region of the inhA gene were investigated. Methods Sputum specimens of smear-positive tuberculosis (TB) patients were subjected to GenoType MTBDRplus assay to identify ka…
Yan L, Niu X, Liang K, Guan F, Yu X, et al.
Background: Tuberculosis (TB) is the second largest infectious disease killer in China, and the increasing prevalence of drug-resistant TB patients complicates treatment efforts and raises associated costs. Research on the mechanisms and characteristics of drug-resistant TB contr…
Mesfin EA, Beyene D, Tesfaye A, Admasu A, Addise D, et al.
Background Multidrug drug-resistant tuberculosis (MDR-TB) is a major health problem and seriously threatens TB control and prevention efforts globally. Ethiopia is among the 30th highest TB burden countries for MDR-TB with 14% prevalence among previously treated cases. The focus …
N H, P SR, Sura M, Daddam JR
Tuberculosis is the most dangerous disease causing maximum deaths than any other, caused by single infectious agent. Due to multidrug resistant of Mycobacterium tuberculosis strains, there is a need of new drugs and drug targets. In this work, we have selected RmlD (α-dTDP-6-deox…
Izudi J, Tamwesigire IK, Bajunirwe F
… treated persons with bacteriologically confirmed pulmonary tuberculosis (BC-PTB) have increased risk of developing multi-drug resistant or rifampicin resistant tuberculosis (MDR/RR-TB). Surveillance for resistance is critical to identify and treat MDR/RR-TB to ensure cure and pr…
Kusheno FT, Nguse TM, Gebretekle GB, Gebretekle GB
Background Multidrug-resistant tuberculosis (MDR-TB) is becoming a major challenge of tuberculosis (TB) control program globally but more serious in developing countries like Ethiopia. In 2013, a survey result showed that in Ethiopia, tuberculosis patients from new cases and retr…
Ogundipe T, Otolorin A, Ogundipe F, Sran G, Abbas G, et al.
Multidrug-resistant tuberculosis (MDR-TB) occurs when strains of Mycobacterium are resistant to the first-line anti-tuberculosis regimen. We present the case of a 22-year-old immigrant female of African descent who presented to her primary care physician complaining of a two-mont…
Gebretsadik D, Ahmed N, Kebede E, Mohammed M, Belete MA
Background Tuberculosis is a communicable disease that is a major cause of ill health, one of the top 10 causes of death worldwide, and the leading cause of death from a single infectious agent, even ranking above human immuno-deficiency virus (HIV/AIDS). Objective To assess the …